Genome-wide association study of genetic factors related to confectionery intake: Potential roles of the ADIPOQ gene

Kenji Wakai, Keitaro Matsuo, Fumihiko Matsuda, Ryo Yamada, Meiko Takahashi, Takahisa Kawaguchi, Yasushi Yatabe, Hidemi Ito, Satoyo Hosono, Kazuo Tajima, Mariko Naito, Emi Morita, Guang Yin, Tatsuhiko Sakamoto, Naoyuki Takashima, Sadao Suzuki, Noriko Nakahata, Haruo Mikami, Keizo Ohnaka, Yoshiyuki WatanabeKokichi Arisawa, Michiaki Kubo, Nobuyuki Hamajima, Hideo Tanaka

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: The excessive consumption of confectionery might have adverse effects on human health. To screen genetic factors associated with confectionery-intake frequency, a genome-wide association study (GWAS) in Japan was conducted. Design and Methods: For the discovery phase (stage 1), we conducted a GWAS of 939 noncancer patients in a cancer hospital. Additive models were used to test associations between genotypes of approximately 500,000 single-nucleotide polymorphisms (SNPs) and the confectionery-intake score (based on intake frequency). We followed-up association signals with P < 1 × 10-5 and minor allele frequency >0.01 in stage 1 by genotyping the SNPs of 4,491 participants in a cross-sectional study within a cohort (replication phase [stage 2]). Results: We identified 12 SNPs in stage 1 that were potentially related to confectionery intake. In stage 2, this association was replicated for one SNP (rs822396; P = 0.049 for stage 2 and 4.2 × 10-5 for stage 1+2) in intron 1 of the ADIPOQ gene, which encodes the adipokine adiponectin. Conclusions: Given the biological plausibility and previous relevant findings, the association of an SNP in the ADIPOQ gene with a preference for confectionery is worthy of follow-up and provides a good working hypothesis for experimental testing.

Original languageEnglish
Pages (from-to)2413-2419
Number of pages7
JournalObesity
Volume21
Issue number11
DOIs
Publication statusPublished - 01-11-2013

Fingerprint

Genome-Wide Association Study
Single Nucleotide Polymorphism
Genes
Cancer Care Facilities
Adipokines
Adiponectin
Introns
Japan
Cross-Sectional Studies
Genotype
Health

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Wakai, K., Matsuo, K., Matsuda, F., Yamada, R., Takahashi, M., Kawaguchi, T., ... Tanaka, H. (2013). Genome-wide association study of genetic factors related to confectionery intake: Potential roles of the ADIPOQ gene. Obesity, 21(11), 2413-2419. https://doi.org/10.1002/oby.20316
Wakai, Kenji ; Matsuo, Keitaro ; Matsuda, Fumihiko ; Yamada, Ryo ; Takahashi, Meiko ; Kawaguchi, Takahisa ; Yatabe, Yasushi ; Ito, Hidemi ; Hosono, Satoyo ; Tajima, Kazuo ; Naito, Mariko ; Morita, Emi ; Yin, Guang ; Sakamoto, Tatsuhiko ; Takashima, Naoyuki ; Suzuki, Sadao ; Nakahata, Noriko ; Mikami, Haruo ; Ohnaka, Keizo ; Watanabe, Yoshiyuki ; Arisawa, Kokichi ; Kubo, Michiaki ; Hamajima, Nobuyuki ; Tanaka, Hideo. / Genome-wide association study of genetic factors related to confectionery intake : Potential roles of the ADIPOQ gene. In: Obesity. 2013 ; Vol. 21, No. 11. pp. 2413-2419.
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abstract = "Objective: The excessive consumption of confectionery might have adverse effects on human health. To screen genetic factors associated with confectionery-intake frequency, a genome-wide association study (GWAS) in Japan was conducted. Design and Methods: For the discovery phase (stage 1), we conducted a GWAS of 939 noncancer patients in a cancer hospital. Additive models were used to test associations between genotypes of approximately 500,000 single-nucleotide polymorphisms (SNPs) and the confectionery-intake score (based on intake frequency). We followed-up association signals with P < 1 × 10-5 and minor allele frequency >0.01 in stage 1 by genotyping the SNPs of 4,491 participants in a cross-sectional study within a cohort (replication phase [stage 2]). Results: We identified 12 SNPs in stage 1 that were potentially related to confectionery intake. In stage 2, this association was replicated for one SNP (rs822396; P = 0.049 for stage 2 and 4.2 × 10-5 for stage 1+2) in intron 1 of the ADIPOQ gene, which encodes the adipokine adiponectin. Conclusions: Given the biological plausibility and previous relevant findings, the association of an SNP in the ADIPOQ gene with a preference for confectionery is worthy of follow-up and provides a good working hypothesis for experimental testing.",
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Wakai, K, Matsuo, K, Matsuda, F, Yamada, R, Takahashi, M, Kawaguchi, T, Yatabe, Y, Ito, H, Hosono, S, Tajima, K, Naito, M, Morita, E, Yin, G, Sakamoto, T, Takashima, N, Suzuki, S, Nakahata, N, Mikami, H, Ohnaka, K, Watanabe, Y, Arisawa, K, Kubo, M, Hamajima, N & Tanaka, H 2013, 'Genome-wide association study of genetic factors related to confectionery intake: Potential roles of the ADIPOQ gene', Obesity, vol. 21, no. 11, pp. 2413-2419. https://doi.org/10.1002/oby.20316

Genome-wide association study of genetic factors related to confectionery intake : Potential roles of the ADIPOQ gene. / Wakai, Kenji; Matsuo, Keitaro; Matsuda, Fumihiko; Yamada, Ryo; Takahashi, Meiko; Kawaguchi, Takahisa; Yatabe, Yasushi; Ito, Hidemi; Hosono, Satoyo; Tajima, Kazuo; Naito, Mariko; Morita, Emi; Yin, Guang; Sakamoto, Tatsuhiko; Takashima, Naoyuki; Suzuki, Sadao; Nakahata, Noriko; Mikami, Haruo; Ohnaka, Keizo; Watanabe, Yoshiyuki; Arisawa, Kokichi; Kubo, Michiaki; Hamajima, Nobuyuki; Tanaka, Hideo.

In: Obesity, Vol. 21, No. 11, 01.11.2013, p. 2413-2419.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Genome-wide association study of genetic factors related to confectionery intake

T2 - Potential roles of the ADIPOQ gene

AU - Wakai, Kenji

AU - Matsuo, Keitaro

AU - Matsuda, Fumihiko

AU - Yamada, Ryo

AU - Takahashi, Meiko

AU - Kawaguchi, Takahisa

AU - Yatabe, Yasushi

AU - Ito, Hidemi

AU - Hosono, Satoyo

AU - Tajima, Kazuo

AU - Naito, Mariko

AU - Morita, Emi

AU - Yin, Guang

AU - Sakamoto, Tatsuhiko

AU - Takashima, Naoyuki

AU - Suzuki, Sadao

AU - Nakahata, Noriko

AU - Mikami, Haruo

AU - Ohnaka, Keizo

AU - Watanabe, Yoshiyuki

AU - Arisawa, Kokichi

AU - Kubo, Michiaki

AU - Hamajima, Nobuyuki

AU - Tanaka, Hideo

PY - 2013/11/1

Y1 - 2013/11/1

N2 - Objective: The excessive consumption of confectionery might have adverse effects on human health. To screen genetic factors associated with confectionery-intake frequency, a genome-wide association study (GWAS) in Japan was conducted. Design and Methods: For the discovery phase (stage 1), we conducted a GWAS of 939 noncancer patients in a cancer hospital. Additive models were used to test associations between genotypes of approximately 500,000 single-nucleotide polymorphisms (SNPs) and the confectionery-intake score (based on intake frequency). We followed-up association signals with P < 1 × 10-5 and minor allele frequency >0.01 in stage 1 by genotyping the SNPs of 4,491 participants in a cross-sectional study within a cohort (replication phase [stage 2]). Results: We identified 12 SNPs in stage 1 that were potentially related to confectionery intake. In stage 2, this association was replicated for one SNP (rs822396; P = 0.049 for stage 2 and 4.2 × 10-5 for stage 1+2) in intron 1 of the ADIPOQ gene, which encodes the adipokine adiponectin. Conclusions: Given the biological plausibility and previous relevant findings, the association of an SNP in the ADIPOQ gene with a preference for confectionery is worthy of follow-up and provides a good working hypothesis for experimental testing.

AB - Objective: The excessive consumption of confectionery might have adverse effects on human health. To screen genetic factors associated with confectionery-intake frequency, a genome-wide association study (GWAS) in Japan was conducted. Design and Methods: For the discovery phase (stage 1), we conducted a GWAS of 939 noncancer patients in a cancer hospital. Additive models were used to test associations between genotypes of approximately 500,000 single-nucleotide polymorphisms (SNPs) and the confectionery-intake score (based on intake frequency). We followed-up association signals with P < 1 × 10-5 and minor allele frequency >0.01 in stage 1 by genotyping the SNPs of 4,491 participants in a cross-sectional study within a cohort (replication phase [stage 2]). Results: We identified 12 SNPs in stage 1 that were potentially related to confectionery intake. In stage 2, this association was replicated for one SNP (rs822396; P = 0.049 for stage 2 and 4.2 × 10-5 for stage 1+2) in intron 1 of the ADIPOQ gene, which encodes the adipokine adiponectin. Conclusions: Given the biological plausibility and previous relevant findings, the association of an SNP in the ADIPOQ gene with a preference for confectionery is worthy of follow-up and provides a good working hypothesis for experimental testing.

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Wakai K, Matsuo K, Matsuda F, Yamada R, Takahashi M, Kawaguchi T et al. Genome-wide association study of genetic factors related to confectionery intake: Potential roles of the ADIPOQ gene. Obesity. 2013 Nov 1;21(11):2413-2419. https://doi.org/10.1002/oby.20316