Genome-wide association study of hematological and biochemical traits in a Japanese population

Yoichiro Kamatani, Koichi Matsuda, Yukinori Okada, Michiaki Kubo, Naoya Hosono, Yataro Daigo, Yusuke Nakamura, Naoyuki Kamatani

Research output: Contribution to journalArticle

338 Citations (Scopus)

Abstract

We report genome-wide association studies for hematological and biochemical traits from 14,700 Japanese individuals. We identified 60 associations for 8 hematological traits and 29 associations for 12 biochemical traits at genome-wide significance levels (P 5 × 10 8). Of these, 46 associations were new to this study and 43 replicated previous reports. We compared these associated loci with those reported in similar GWAS in European populations. When the minor allele frequency was 10% in the Japanese population, 32 (94.1%) and 31 (91.2%) of the 34 hematological loci previously reported to be associated in a European population were replicated with P-values less than 0.05 and 0.01, respectively, and 31 (73.8%) and 27 (64.3%) of the 42 European biochemical loci were replicated.

Original languageEnglish
Pages (from-to)210-215
Number of pages6
JournalNature Genetics
Volume42
Issue number3
DOIs
Publication statusPublished - 03-2010

All Science Journal Classification (ASJC) codes

  • Genetics

Fingerprint Dive into the research topics of 'Genome-wide association study of hematological and biochemical traits in a Japanese population'. Together they form a unique fingerprint.

  • Cite this

    Kamatani, Y., Matsuda, K., Okada, Y., Kubo, M., Hosono, N., Daigo, Y., Nakamura, Y., & Kamatani, N. (2010). Genome-wide association study of hematological and biochemical traits in a Japanese population. Nature Genetics, 42(3), 210-215. https://doi.org/10.1038/ng.531