Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head

Yuma Sakamoto, Takuaki Yamamoto, Nobuhiko Sugano, Daisuke Takahashi, Toshiyuki Watanabe, Takashi Atsumi, Junichi Nakamura, Yukiharu Hasegawa, Koichi Akashi, Ichiei Narita, Takeshi Miyamoto, Tsutomu Takeuchi, Katsunori Ikari, Koichi Amano, Atsuhiro Fujie, Toshikazu Kubo, Yoshifumi Tada, Ayumi Kaneuji, Hiroaki Nakamura, Tomoya Miyamura & 70 others Tamon Kabata, Ken Yamaji, Takahiro Okawa, Akihiro Sudo, Kenji Ohzono, Yoshiya Tanaka, Yuji Yasunaga, Shuichi Matsuda, Yuuki Imai, Yasuharu Nakashima, Goro Motomura, Satoshi Ikemura, Ryosuke Yamaguchi, Kazuyuki Karasuyama, Kazuhiko Sonoda, Takashi Nishii, Takashi Sakai, Masaki Takao, Tohru Irie, Tsuyoshi Asano, Norimasa Iwasaki, Tatsuya Atsumi, Satoshi Tamaoki, Ryosuke Nakanishi, Satoe Tanabe, Shunji Kishida, Shigeo Hagiwara, Taisuke Seki, Hiroshi Tsukamoto, Hiroaki Niiro, Yojiro Arinobu, Mitsuteru Akahoshi, Hiroshi Mitoma, Masahiro Ayano, Takeshi Kuroda, Yoshiaki Toyama, Atsushi Funayama, Hironari Hanaoka, Kunihiro Yamaoka, Yasushi Kawaguchi, Hisashi Yamanaka, Tetsuji Hosozawa, Shigeki Momohara, Kentaro Chino, Mikihiro Fujioka, Keichiro Ueshima, Masashi Ishida, Masazumi Saito, Shigeki Hayashi, Akira Ikegami, Toru Ichiseki, Shigekazu Mizokawa, Yoichi Ohta, Yoshitomo Kajino, Fumio Sekiya, Fujio Higuchi, Masahiro Hasegawa, Noriki Miyamoto, Shinichi Miyazaki, Toshio Yamaguchi, Wataru Ando, Kazuyoshi Saito, Kazuhisa Nakano, Yutaka Kuroda, Takuma Yamasaki, Masato Akiyama, Michiaki Kubo, Yoichiro Kamatani, Yukihide Iwamoto, Shiro Ikegawa

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Idiopathic osteonecrosis of the femoral head (IONFH) is an ischemic disorder that causes bone necrosis of the femoral head, resulting in hip joint dysfunction. IONFH is a polygenic disease and steroid and alcohol have already known to increase its risk; however, the mechanism of IONFH remains to be elucidated. We performed a genome-wide association study using ~60,000 subjects and found two novel loci on chromosome 20q12 and 12q24. Big data analyses identified LINC01370 as a candidate susceptibility gene in the 20q12 locus. Stratified analysis by IONFH risk factors suggested that the 12q24 locus was associated with IONFH through drinking capacity. Our findings would shed new light on pathophysiology of IONFH.

Original languageEnglish
Article number15035
JournalScientific reports
Volume7
Issue number1
DOIs
Publication statusPublished - 01-12-2017

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Osteonecrosis
Genome-Wide Association Study
Thigh
Hip Joint
Drinking
Chromosomes
Steroids
Alcohols
Genes

All Science Journal Classification (ASJC) codes

  • General

Cite this

Sakamoto, Y., Yamamoto, T., Sugano, N., Takahashi, D., Watanabe, T., Atsumi, T., ... Ikegawa, S. (2017). Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head. Scientific reports, 7(1), [15035]. https://doi.org/10.1038/s41598-017-14778-y
Sakamoto, Yuma ; Yamamoto, Takuaki ; Sugano, Nobuhiko ; Takahashi, Daisuke ; Watanabe, Toshiyuki ; Atsumi, Takashi ; Nakamura, Junichi ; Hasegawa, Yukiharu ; Akashi, Koichi ; Narita, Ichiei ; Miyamoto, Takeshi ; Takeuchi, Tsutomu ; Ikari, Katsunori ; Amano, Koichi ; Fujie, Atsuhiro ; Kubo, Toshikazu ; Tada, Yoshifumi ; Kaneuji, Ayumi ; Nakamura, Hiroaki ; Miyamura, Tomoya ; Kabata, Tamon ; Yamaji, Ken ; Okawa, Takahiro ; Sudo, Akihiro ; Ohzono, Kenji ; Tanaka, Yoshiya ; Yasunaga, Yuji ; Matsuda, Shuichi ; Imai, Yuuki ; Nakashima, Yasuharu ; Motomura, Goro ; Ikemura, Satoshi ; Yamaguchi, Ryosuke ; Karasuyama, Kazuyuki ; Sonoda, Kazuhiko ; Nishii, Takashi ; Sakai, Takashi ; Takao, Masaki ; Irie, Tohru ; Asano, Tsuyoshi ; Iwasaki, Norimasa ; Atsumi, Tatsuya ; Tamaoki, Satoshi ; Nakanishi, Ryosuke ; Tanabe, Satoe ; Kishida, Shunji ; Hagiwara, Shigeo ; Seki, Taisuke ; Tsukamoto, Hiroshi ; Niiro, Hiroaki ; Arinobu, Yojiro ; Akahoshi, Mitsuteru ; Mitoma, Hiroshi ; Ayano, Masahiro ; Kuroda, Takeshi ; Toyama, Yoshiaki ; Funayama, Atsushi ; Hanaoka, Hironari ; Yamaoka, Kunihiro ; Kawaguchi, Yasushi ; Yamanaka, Hisashi ; Hosozawa, Tetsuji ; Momohara, Shigeki ; Chino, Kentaro ; Fujioka, Mikihiro ; Ueshima, Keichiro ; Ishida, Masashi ; Saito, Masazumi ; Hayashi, Shigeki ; Ikegami, Akira ; Ichiseki, Toru ; Mizokawa, Shigekazu ; Ohta, Yoichi ; Kajino, Yoshitomo ; Sekiya, Fumio ; Higuchi, Fujio ; Hasegawa, Masahiro ; Miyamoto, Noriki ; Miyazaki, Shinichi ; Yamaguchi, Toshio ; Ando, Wataru ; Saito, Kazuyoshi ; Nakano, Kazuhisa ; Kuroda, Yutaka ; Yamasaki, Takuma ; Akiyama, Masato ; Kubo, Michiaki ; Kamatani, Yoichiro ; Iwamoto, Yukihide ; Ikegawa, Shiro. / Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head. In: Scientific reports. 2017 ; Vol. 7, No. 1.
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abstract = "Idiopathic osteonecrosis of the femoral head (IONFH) is an ischemic disorder that causes bone necrosis of the femoral head, resulting in hip joint dysfunction. IONFH is a polygenic disease and steroid and alcohol have already known to increase its risk; however, the mechanism of IONFH remains to be elucidated. We performed a genome-wide association study using ~60,000 subjects and found two novel loci on chromosome 20q12 and 12q24. Big data analyses identified LINC01370 as a candidate susceptibility gene in the 20q12 locus. Stratified analysis by IONFH risk factors suggested that the 12q24 locus was associated with IONFH through drinking capacity. Our findings would shed new light on pathophysiology of IONFH.",
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Sakamoto, Y, Yamamoto, T, Sugano, N, Takahashi, D, Watanabe, T, Atsumi, T, Nakamura, J, Hasegawa, Y, Akashi, K, Narita, I, Miyamoto, T, Takeuchi, T, Ikari, K, Amano, K, Fujie, A, Kubo, T, Tada, Y, Kaneuji, A, Nakamura, H, Miyamura, T, Kabata, T, Yamaji, K, Okawa, T, Sudo, A, Ohzono, K, Tanaka, Y, Yasunaga, Y, Matsuda, S, Imai, Y, Nakashima, Y, Motomura, G, Ikemura, S, Yamaguchi, R, Karasuyama, K, Sonoda, K, Nishii, T, Sakai, T, Takao, M, Irie, T, Asano, T, Iwasaki, N, Atsumi, T, Tamaoki, S, Nakanishi, R, Tanabe, S, Kishida, S, Hagiwara, S, Seki, T, Tsukamoto, H, Niiro, H, Arinobu, Y, Akahoshi, M, Mitoma, H, Ayano, M, Kuroda, T, Toyama, Y, Funayama, A, Hanaoka, H, Yamaoka, K, Kawaguchi, Y, Yamanaka, H, Hosozawa, T, Momohara, S, Chino, K, Fujioka, M, Ueshima, K, Ishida, M, Saito, M, Hayashi, S, Ikegami, A, Ichiseki, T, Mizokawa, S, Ohta, Y, Kajino, Y, Sekiya, F, Higuchi, F, Hasegawa, M, Miyamoto, N, Miyazaki, S, Yamaguchi, T, Ando, W, Saito, K, Nakano, K, Kuroda, Y, Yamasaki, T, Akiyama, M, Kubo, M, Kamatani, Y, Iwamoto, Y & Ikegawa, S 2017, 'Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head', Scientific reports, vol. 7, no. 1, 15035. https://doi.org/10.1038/s41598-017-14778-y

Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head. / Sakamoto, Yuma; Yamamoto, Takuaki; Sugano, Nobuhiko; Takahashi, Daisuke; Watanabe, Toshiyuki; Atsumi, Takashi; Nakamura, Junichi; Hasegawa, Yukiharu; Akashi, Koichi; Narita, Ichiei; Miyamoto, Takeshi; Takeuchi, Tsutomu; Ikari, Katsunori; Amano, Koichi; Fujie, Atsuhiro; Kubo, Toshikazu; Tada, Yoshifumi; Kaneuji, Ayumi; Nakamura, Hiroaki; Miyamura, Tomoya; Kabata, Tamon; Yamaji, Ken; Okawa, Takahiro; Sudo, Akihiro; Ohzono, Kenji; Tanaka, Yoshiya; Yasunaga, Yuji; Matsuda, Shuichi; Imai, Yuuki; Nakashima, Yasuharu; Motomura, Goro; Ikemura, Satoshi; Yamaguchi, Ryosuke; Karasuyama, Kazuyuki; Sonoda, Kazuhiko; Nishii, Takashi; Sakai, Takashi; Takao, Masaki; Irie, Tohru; Asano, Tsuyoshi; Iwasaki, Norimasa; Atsumi, Tatsuya; Tamaoki, Satoshi; Nakanishi, Ryosuke; Tanabe, Satoe; Kishida, Shunji; Hagiwara, Shigeo; Seki, Taisuke; Tsukamoto, Hiroshi; Niiro, Hiroaki; Arinobu, Yojiro; Akahoshi, Mitsuteru; Mitoma, Hiroshi; Ayano, Masahiro; Kuroda, Takeshi; Toyama, Yoshiaki; Funayama, Atsushi; Hanaoka, Hironari; Yamaoka, Kunihiro; Kawaguchi, Yasushi; Yamanaka, Hisashi; Hosozawa, Tetsuji; Momohara, Shigeki; Chino, Kentaro; Fujioka, Mikihiro; Ueshima, Keichiro; Ishida, Masashi; Saito, Masazumi; Hayashi, Shigeki; Ikegami, Akira; Ichiseki, Toru; Mizokawa, Shigekazu; Ohta, Yoichi; Kajino, Yoshitomo; Sekiya, Fumio; Higuchi, Fujio; Hasegawa, Masahiro; Miyamoto, Noriki; Miyazaki, Shinichi; Yamaguchi, Toshio; Ando, Wataru; Saito, Kazuyoshi; Nakano, Kazuhisa; Kuroda, Yutaka; Yamasaki, Takuma; Akiyama, Masato; Kubo, Michiaki; Kamatani, Yoichiro; Iwamoto, Yukihide; Ikegawa, Shiro.

In: Scientific reports, Vol. 7, No. 1, 15035, 01.12.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head

AU - Sakamoto, Yuma

AU - Yamamoto, Takuaki

AU - Sugano, Nobuhiko

AU - Takahashi, Daisuke

AU - Watanabe, Toshiyuki

AU - Atsumi, Takashi

AU - Nakamura, Junichi

AU - Hasegawa, Yukiharu

AU - Akashi, Koichi

AU - Narita, Ichiei

AU - Miyamoto, Takeshi

AU - Takeuchi, Tsutomu

AU - Ikari, Katsunori

AU - Amano, Koichi

AU - Fujie, Atsuhiro

AU - Kubo, Toshikazu

AU - Tada, Yoshifumi

AU - Kaneuji, Ayumi

AU - Nakamura, Hiroaki

AU - Miyamura, Tomoya

AU - Kabata, Tamon

AU - Yamaji, Ken

AU - Okawa, Takahiro

AU - Sudo, Akihiro

AU - Ohzono, Kenji

AU - Tanaka, Yoshiya

AU - Yasunaga, Yuji

AU - Matsuda, Shuichi

AU - Imai, Yuuki

AU - Nakashima, Yasuharu

AU - Motomura, Goro

AU - Ikemura, Satoshi

AU - Yamaguchi, Ryosuke

AU - Karasuyama, Kazuyuki

AU - Sonoda, Kazuhiko

AU - Nishii, Takashi

AU - Sakai, Takashi

AU - Takao, Masaki

AU - Irie, Tohru

AU - Asano, Tsuyoshi

AU - Iwasaki, Norimasa

AU - Atsumi, Tatsuya

AU - Tamaoki, Satoshi

AU - Nakanishi, Ryosuke

AU - Tanabe, Satoe

AU - Kishida, Shunji

AU - Hagiwara, Shigeo

AU - Seki, Taisuke

AU - Tsukamoto, Hiroshi

AU - Niiro, Hiroaki

AU - Arinobu, Yojiro

AU - Akahoshi, Mitsuteru

AU - Mitoma, Hiroshi

AU - Ayano, Masahiro

AU - Kuroda, Takeshi

AU - Toyama, Yoshiaki

AU - Funayama, Atsushi

AU - Hanaoka, Hironari

AU - Yamaoka, Kunihiro

AU - Kawaguchi, Yasushi

AU - Yamanaka, Hisashi

AU - Hosozawa, Tetsuji

AU - Momohara, Shigeki

AU - Chino, Kentaro

AU - Fujioka, Mikihiro

AU - Ueshima, Keichiro

AU - Ishida, Masashi

AU - Saito, Masazumi

AU - Hayashi, Shigeki

AU - Ikegami, Akira

AU - Ichiseki, Toru

AU - Mizokawa, Shigekazu

AU - Ohta, Yoichi

AU - Kajino, Yoshitomo

AU - Sekiya, Fumio

AU - Higuchi, Fujio

AU - Hasegawa, Masahiro

AU - Miyamoto, Noriki

AU - Miyazaki, Shinichi

AU - Yamaguchi, Toshio

AU - Ando, Wataru

AU - Saito, Kazuyoshi

AU - Nakano, Kazuhisa

AU - Kuroda, Yutaka

AU - Yamasaki, Takuma

AU - Akiyama, Masato

AU - Kubo, Michiaki

AU - Kamatani, Yoichiro

AU - Iwamoto, Yukihide

AU - Ikegawa, Shiro

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Idiopathic osteonecrosis of the femoral head (IONFH) is an ischemic disorder that causes bone necrosis of the femoral head, resulting in hip joint dysfunction. IONFH is a polygenic disease and steroid and alcohol have already known to increase its risk; however, the mechanism of IONFH remains to be elucidated. We performed a genome-wide association study using ~60,000 subjects and found two novel loci on chromosome 20q12 and 12q24. Big data analyses identified LINC01370 as a candidate susceptibility gene in the 20q12 locus. Stratified analysis by IONFH risk factors suggested that the 12q24 locus was associated with IONFH through drinking capacity. Our findings would shed new light on pathophysiology of IONFH.

AB - Idiopathic osteonecrosis of the femoral head (IONFH) is an ischemic disorder that causes bone necrosis of the femoral head, resulting in hip joint dysfunction. IONFH is a polygenic disease and steroid and alcohol have already known to increase its risk; however, the mechanism of IONFH remains to be elucidated. We performed a genome-wide association study using ~60,000 subjects and found two novel loci on chromosome 20q12 and 12q24. Big data analyses identified LINC01370 as a candidate susceptibility gene in the 20q12 locus. Stratified analysis by IONFH risk factors suggested that the 12q24 locus was associated with IONFH through drinking capacity. Our findings would shed new light on pathophysiology of IONFH.

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U2 - 10.1038/s41598-017-14778-y

DO - 10.1038/s41598-017-14778-y

M3 - Article

VL - 7

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 15035

ER -

Sakamoto Y, Yamamoto T, Sugano N, Takahashi D, Watanabe T, Atsumi T et al. Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head. Scientific reports. 2017 Dec 1;7(1). 15035. https://doi.org/10.1038/s41598-017-14778-y