Abstract
Idiopathic osteonecrosis of the femoral head (IONFH) is an ischemic disorder that causes bone necrosis of the femoral head, resulting in hip joint dysfunction. IONFH is a polygenic disease and steroid and alcohol have already known to increase its risk; however, the mechanism of IONFH remains to be elucidated. We performed a genome-wide association study using ~60,000 subjects and found two novel loci on chromosome 20q12 and 12q24. Big data analyses identified LINC01370 as a candidate susceptibility gene in the 20q12 locus. Stratified analysis by IONFH risk factors suggested that the 12q24 locus was associated with IONFH through drinking capacity. Our findings would shed new light on pathophysiology of IONFH.
Original language | English |
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Article number | 15035 |
Journal | Scientific reports |
Volume | 7 |
Issue number | 1 |
DOIs | |
Publication status | Published - 01-12-2017 |
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All Science Journal Classification (ASJC) codes
- General
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Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head. / Sakamoto, Yuma; Yamamoto, Takuaki; Sugano, Nobuhiko; Takahashi, Daisuke; Watanabe, Toshiyuki; Atsumi, Takashi; Nakamura, Junichi; Hasegawa, Yukiharu; Akashi, Koichi; Narita, Ichiei; Miyamoto, Takeshi; Takeuchi, Tsutomu; Ikari, Katsunori; Amano, Koichi; Fujie, Atsuhiro; Kubo, Toshikazu; Tada, Yoshifumi; Kaneuji, Ayumi; Nakamura, Hiroaki; Miyamura, Tomoya; Kabata, Tamon; Yamaji, Ken; Okawa, Takahiro; Sudo, Akihiro; Ohzono, Kenji; Tanaka, Yoshiya; Yasunaga, Yuji; Matsuda, Shuichi; Imai, Yuuki; Nakashima, Yasuharu; Motomura, Goro; Ikemura, Satoshi; Yamaguchi, Ryosuke; Karasuyama, Kazuyuki; Sonoda, Kazuhiko; Nishii, Takashi; Sakai, Takashi; Takao, Masaki; Irie, Tohru; Asano, Tsuyoshi; Iwasaki, Norimasa; Atsumi, Tatsuya; Tamaoki, Satoshi; Nakanishi, Ryosuke; Tanabe, Satoe; Kishida, Shunji; Hagiwara, Shigeo; Seki, Taisuke; Tsukamoto, Hiroshi; Niiro, Hiroaki; Arinobu, Yojiro; Akahoshi, Mitsuteru; Mitoma, Hiroshi; Ayano, Masahiro; Kuroda, Takeshi; Toyama, Yoshiaki; Funayama, Atsushi; Hanaoka, Hironari; Yamaoka, Kunihiro; Kawaguchi, Yasushi; Yamanaka, Hisashi; Hosozawa, Tetsuji; Momohara, Shigeki; Chino, Kentaro; Fujioka, Mikihiro; Ueshima, Keichiro; Ishida, Masashi; Saito, Masazumi; Hayashi, Shigeki; Ikegami, Akira; Ichiseki, Toru; Mizokawa, Shigekazu; Ohta, Yoichi; Kajino, Yoshitomo; Sekiya, Fumio; Higuchi, Fujio; Hasegawa, Masahiro; Miyamoto, Noriki; Miyazaki, Shinichi; Yamaguchi, Toshio; Ando, Wataru; Saito, Kazuyoshi; Nakano, Kazuhisa; Kuroda, Yutaka; Yamasaki, Takuma; Akiyama, Masato; Kubo, Michiaki; Kamatani, Yoichiro; Iwamoto, Yukihide; Ikegawa, Shiro.
In: Scientific reports, Vol. 7, No. 1, 15035, 01.12.2017.Research output: Contribution to journal › Article
TY - JOUR
T1 - Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head
AU - Sakamoto, Yuma
AU - Yamamoto, Takuaki
AU - Sugano, Nobuhiko
AU - Takahashi, Daisuke
AU - Watanabe, Toshiyuki
AU - Atsumi, Takashi
AU - Nakamura, Junichi
AU - Hasegawa, Yukiharu
AU - Akashi, Koichi
AU - Narita, Ichiei
AU - Miyamoto, Takeshi
AU - Takeuchi, Tsutomu
AU - Ikari, Katsunori
AU - Amano, Koichi
AU - Fujie, Atsuhiro
AU - Kubo, Toshikazu
AU - Tada, Yoshifumi
AU - Kaneuji, Ayumi
AU - Nakamura, Hiroaki
AU - Miyamura, Tomoya
AU - Kabata, Tamon
AU - Yamaji, Ken
AU - Okawa, Takahiro
AU - Sudo, Akihiro
AU - Ohzono, Kenji
AU - Tanaka, Yoshiya
AU - Yasunaga, Yuji
AU - Matsuda, Shuichi
AU - Imai, Yuuki
AU - Nakashima, Yasuharu
AU - Motomura, Goro
AU - Ikemura, Satoshi
AU - Yamaguchi, Ryosuke
AU - Karasuyama, Kazuyuki
AU - Sonoda, Kazuhiko
AU - Nishii, Takashi
AU - Sakai, Takashi
AU - Takao, Masaki
AU - Irie, Tohru
AU - Asano, Tsuyoshi
AU - Iwasaki, Norimasa
AU - Atsumi, Tatsuya
AU - Tamaoki, Satoshi
AU - Nakanishi, Ryosuke
AU - Tanabe, Satoe
AU - Kishida, Shunji
AU - Hagiwara, Shigeo
AU - Seki, Taisuke
AU - Tsukamoto, Hiroshi
AU - Niiro, Hiroaki
AU - Arinobu, Yojiro
AU - Akahoshi, Mitsuteru
AU - Mitoma, Hiroshi
AU - Ayano, Masahiro
AU - Kuroda, Takeshi
AU - Toyama, Yoshiaki
AU - Funayama, Atsushi
AU - Hanaoka, Hironari
AU - Yamaoka, Kunihiro
AU - Kawaguchi, Yasushi
AU - Yamanaka, Hisashi
AU - Hosozawa, Tetsuji
AU - Momohara, Shigeki
AU - Chino, Kentaro
AU - Fujioka, Mikihiro
AU - Ueshima, Keichiro
AU - Ishida, Masashi
AU - Saito, Masazumi
AU - Hayashi, Shigeki
AU - Ikegami, Akira
AU - Ichiseki, Toru
AU - Mizokawa, Shigekazu
AU - Ohta, Yoichi
AU - Kajino, Yoshitomo
AU - Sekiya, Fumio
AU - Higuchi, Fujio
AU - Hasegawa, Masahiro
AU - Miyamoto, Noriki
AU - Miyazaki, Shinichi
AU - Yamaguchi, Toshio
AU - Ando, Wataru
AU - Saito, Kazuyoshi
AU - Nakano, Kazuhisa
AU - Kuroda, Yutaka
AU - Yamasaki, Takuma
AU - Akiyama, Masato
AU - Kubo, Michiaki
AU - Kamatani, Yoichiro
AU - Iwamoto, Yukihide
AU - Ikegawa, Shiro
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Idiopathic osteonecrosis of the femoral head (IONFH) is an ischemic disorder that causes bone necrosis of the femoral head, resulting in hip joint dysfunction. IONFH is a polygenic disease and steroid and alcohol have already known to increase its risk; however, the mechanism of IONFH remains to be elucidated. We performed a genome-wide association study using ~60,000 subjects and found two novel loci on chromosome 20q12 and 12q24. Big data analyses identified LINC01370 as a candidate susceptibility gene in the 20q12 locus. Stratified analysis by IONFH risk factors suggested that the 12q24 locus was associated with IONFH through drinking capacity. Our findings would shed new light on pathophysiology of IONFH.
AB - Idiopathic osteonecrosis of the femoral head (IONFH) is an ischemic disorder that causes bone necrosis of the femoral head, resulting in hip joint dysfunction. IONFH is a polygenic disease and steroid and alcohol have already known to increase its risk; however, the mechanism of IONFH remains to be elucidated. We performed a genome-wide association study using ~60,000 subjects and found two novel loci on chromosome 20q12 and 12q24. Big data analyses identified LINC01370 as a candidate susceptibility gene in the 20q12 locus. Stratified analysis by IONFH risk factors suggested that the 12q24 locus was associated with IONFH through drinking capacity. Our findings would shed new light on pathophysiology of IONFH.
UR - http://www.scopus.com/inward/record.url?scp=85033388373&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85033388373&partnerID=8YFLogxK
U2 - 10.1038/s41598-017-14778-y
DO - 10.1038/s41598-017-14778-y
M3 - Article
AN - SCOPUS:85033388373
VL - 7
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 15035
ER -