TY - JOUR
T1 - Genome-wide association study of pancreatic cancer in Japanese population
AU - Low, Siew Kee
AU - Kuchiba, Aya
AU - Zembutsu, Hitoshi
AU - Saito, Akira
AU - Takahashi, Atsushi
AU - Kubo, Michiaki
AU - Daigo, Yataro
AU - Kamatani, Naoyuki
AU - Chiku, Suenori
AU - Totsuka, Hirohiko
AU - Ohnami, Sumiko
AU - Hirose, Hiroshi
AU - Shimada, Kazuaki
AU - Okusaka, Takuji
AU - Yoshida, Teruhiko
AU - Nakamura, Yusuke
AU - Sakamoto, Hiromi
N1 - Funding Information:
Although the affiliations of the following three authors (Akira Saito [Statistical Genetics Analysis Division, StaGen Co., Ltd.], Suenori Chiku [Science Solutions Division, Mizuho Information and Research Institute, Inc.] and Hirohiko Totsuka [Bioinfomatics Group, Research and Development Center, Solution Division]) are in the private sector, each of them worked for one of the corresponding authors, Teruhiko Yoshida, as a part of a contract research solely funded by an academic research fund granted from NiBio ( http://www.nibio.go.jp/english/ ) to T. Yoshida. Therefore, this study neither received any funding from the companies to which the above three authors belong, nor did their affiliating companies per se play any role in this research except that they sent their staff (the above three authors) to the laboratory of Teruhiko Yoshida under a research contract paid by Yoshida's grant. There is no competing interests involved between Teruhiko Yoshida and these companies, including intellectual properties. The authors also confirm that they can adhere to all the PLoS ONE policies on sharing data and materials.
PY - 2010
Y1 - 2010
N2 - Pancreatic cancer shows very poor prognosis and is the fifth leading cause of cancer death in Japan. Previous studies indicated some genetic factors contributing to the development and progression of pancreatic cancer; however, there are limited reports for common genetic variants to be associated with this disease, especially in the Asian population. We have conducted a genome-wide association study (GWAS) using 991 invasive pancreatic ductal adenocarcinoma cases and 5,209 controls, and identified three loci showing significant association (P-value <5×10-7) with susceptibility to pancreatic cancer. The SNPs that showed significant association carried estimated odds ratios of 1.29, 1.32, and 3.73 with 95% confidence intervals of 1.17-1.43, 1.19-1.47, and 2.24-6.21; P-value of 3.30×10-7, 3.30×10-7, and 4.41×10-7; located on chromosomes 6p25.3, 12p11.21 and 7q36.2, respectively. These associated SNPs are located within linkage disequilibrium blocks containing genes that have been implicated some roles in the oncogenesis of pancreatic cancer.
AB - Pancreatic cancer shows very poor prognosis and is the fifth leading cause of cancer death in Japan. Previous studies indicated some genetic factors contributing to the development and progression of pancreatic cancer; however, there are limited reports for common genetic variants to be associated with this disease, especially in the Asian population. We have conducted a genome-wide association study (GWAS) using 991 invasive pancreatic ductal adenocarcinoma cases and 5,209 controls, and identified three loci showing significant association (P-value <5×10-7) with susceptibility to pancreatic cancer. The SNPs that showed significant association carried estimated odds ratios of 1.29, 1.32, and 3.73 with 95% confidence intervals of 1.17-1.43, 1.19-1.47, and 2.24-6.21; P-value of 3.30×10-7, 3.30×10-7, and 4.41×10-7; located on chromosomes 6p25.3, 12p11.21 and 7q36.2, respectively. These associated SNPs are located within linkage disequilibrium blocks containing genes that have been implicated some roles in the oncogenesis of pancreatic cancer.
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U2 - 10.1371/journal.pone.0011824
DO - 10.1371/journal.pone.0011824
M3 - Article
C2 - 20686608
AN - SCOPUS:77955606616
SN - 1932-6203
VL - 5
JO - PloS one
JF - PloS one
IS - 7
M1 - e11824
ER -
