Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p

Tadao Arinami, Tsuyuka Ohtsuki, Hiroki Ishiguro, Hiroshi Ujike, Yuji Tanaka, Yukitaka Morita, Mari Mineta, Masashi Takeichi, Shigeto Yamada, Akira Imamura, Koichi Ohara, Haruo Shibuya, Kenshiro Ohara, Yasuo Suzuki, Tatsuyuki Muratake, Naoshi Kaneko, Toshiyuki Someya, Toshiya Inada, Takeo Yoshikawa, Tomoko Toyota & 32 others Kazuo Yamada, Takuya Kojima, Sakae Takahashi, Ohmori Osamu, Takahiro Shinkai, Michiko Nakamura, Hiroshi Fukuzako, Tomo Hashiguchi, Shin Ich Niwa, Takuya Ueno, Hirokazu Tachikawa, Takafumi Hori, Takashi Asada, Shinichiro Nanko, Hiroshi Kunugi, Ryota Hashimoto, Norio Ozaki, Nakao Iwata, Mutsuo Harano, Heii Arai, Tohru Ohnuma, Ichiro Kusumi, Tsukasa Koyama, Hiroshi Yoneda, Yasuyuki Fukumaki, Hiroki Shibata, Sunao Kaneko, Hisashi Higuchi, Norio Yasui-Furukori, Yohtaro Numachi, Masanari Itokawa, Yujitno Okazaki

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

The Japanese Schizophrenia Sib-Pair Linkage Group (JSSLG) is a multisite collaborative study group that was organized to create a national resource for affected sib pair (ASP) studies of schizophrenia in Japan. We used a high-density single-nucleotide-polymorphism (SNP) genotyping assay, the Illumina BeadArray linkage mapping panel (version 4) comprising 5,861 SNPs, to perform a genomewide linkage analysis of JSSLG samples comprising 236 Japanese families with 268 nonindependent ASPs with schizophrenia. All subjects were Japanese. Among these families, 122 families comprised the same subjects analyzed with short tandem repeat markers. All the probands and their siblings, with the exception of seven siblings with schizoaffective disorder, had schizophrenia. After excluding SNPs with high linkage disequilibrium, we found significant evidence of linkage of schizophrenia to chromosome 1p21.2-1p 13.2 (LOD = 3.39) and suggestive evidence of linkage to 14q11.2 (LOD = 2.87), 14q11.2-q13.2 (LOD = 2.33), and 20p12.1-p11.2 (LOD = 2.33). Although linkage to these regions has received little attention, these regions are included in or partially overlap the 10 regions reported by Lewis et al. that passed the two aggregate criteria of a meta-analysis. Results of the present study-which, to our knowledge, is the first genomewide analysis of schizophrenia in ASPs of a single Asian ethnicity that is comparable to the analyses done of ASPs of European descent-indicate the existence of schizophrenia susceptibility loci that are common to different ethnic groups but that likely have different ethnicity-specific effects.

Original languageEnglish
Pages (from-to)937-944
Number of pages8
JournalAmerican Journal of Human Genetics
Volume77
Issue number6
DOIs
Publication statusPublished - 01-01-2005

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Single Nucleotide Polymorphism
Schizophrenia
Chromosomes
Siblings
Chromosome Mapping
Linkage Disequilibrium
Ethnic Groups
Psychotic Disorders
Microsatellite Repeats
Meta-Analysis
Japan

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Arinami, Tadao ; Ohtsuki, Tsuyuka ; Ishiguro, Hiroki ; Ujike, Hiroshi ; Tanaka, Yuji ; Morita, Yukitaka ; Mineta, Mari ; Takeichi, Masashi ; Yamada, Shigeto ; Imamura, Akira ; Ohara, Koichi ; Shibuya, Haruo ; Ohara, Kenshiro ; Suzuki, Yasuo ; Muratake, Tatsuyuki ; Kaneko, Naoshi ; Someya, Toshiyuki ; Inada, Toshiya ; Yoshikawa, Takeo ; Toyota, Tomoko ; Yamada, Kazuo ; Kojima, Takuya ; Takahashi, Sakae ; Osamu, Ohmori ; Shinkai, Takahiro ; Nakamura, Michiko ; Fukuzako, Hiroshi ; Hashiguchi, Tomo ; Niwa, Shin Ich ; Ueno, Takuya ; Tachikawa, Hirokazu ; Hori, Takafumi ; Asada, Takashi ; Nanko, Shinichiro ; Kunugi, Hiroshi ; Hashimoto, Ryota ; Ozaki, Norio ; Iwata, Nakao ; Harano, Mutsuo ; Arai, Heii ; Ohnuma, Tohru ; Kusumi, Ichiro ; Koyama, Tsukasa ; Yoneda, Hiroshi ; Fukumaki, Yasuyuki ; Shibata, Hiroki ; Kaneko, Sunao ; Higuchi, Hisashi ; Yasui-Furukori, Norio ; Numachi, Yohtaro ; Itokawa, Masanari ; Okazaki, Yujitno. / Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p. In: American Journal of Human Genetics. 2005 ; Vol. 77, No. 6. pp. 937-944.
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abstract = "The Japanese Schizophrenia Sib-Pair Linkage Group (JSSLG) is a multisite collaborative study group that was organized to create a national resource for affected sib pair (ASP) studies of schizophrenia in Japan. We used a high-density single-nucleotide-polymorphism (SNP) genotyping assay, the Illumina BeadArray linkage mapping panel (version 4) comprising 5,861 SNPs, to perform a genomewide linkage analysis of JSSLG samples comprising 236 Japanese families with 268 nonindependent ASPs with schizophrenia. All subjects were Japanese. Among these families, 122 families comprised the same subjects analyzed with short tandem repeat markers. All the probands and their siblings, with the exception of seven siblings with schizoaffective disorder, had schizophrenia. After excluding SNPs with high linkage disequilibrium, we found significant evidence of linkage of schizophrenia to chromosome 1p21.2-1p 13.2 (LOD = 3.39) and suggestive evidence of linkage to 14q11.2 (LOD = 2.87), 14q11.2-q13.2 (LOD = 2.33), and 20p12.1-p11.2 (LOD = 2.33). Although linkage to these regions has received little attention, these regions are included in or partially overlap the 10 regions reported by Lewis et al. that passed the two aggregate criteria of a meta-analysis. Results of the present study-which, to our knowledge, is the first genomewide analysis of schizophrenia in ASPs of a single Asian ethnicity that is comparable to the analyses done of ASPs of European descent-indicate the existence of schizophrenia susceptibility loci that are common to different ethnic groups but that likely have different ethnicity-specific effects.",
author = "Tadao Arinami and Tsuyuka Ohtsuki and Hiroki Ishiguro and Hiroshi Ujike and Yuji Tanaka and Yukitaka Morita and Mari Mineta and Masashi Takeichi and Shigeto Yamada and Akira Imamura and Koichi Ohara and Haruo Shibuya and Kenshiro Ohara and Yasuo Suzuki and Tatsuyuki Muratake and Naoshi Kaneko and Toshiyuki Someya and Toshiya Inada and Takeo Yoshikawa and Tomoko Toyota and Kazuo Yamada and Takuya Kojima and Sakae Takahashi and Ohmori Osamu and Takahiro Shinkai and Michiko Nakamura and Hiroshi Fukuzako and Tomo Hashiguchi and Niwa, {Shin Ich} and Takuya Ueno and Hirokazu Tachikawa and Takafumi Hori and Takashi Asada and Shinichiro Nanko and Hiroshi Kunugi and Ryota Hashimoto and Norio Ozaki and Nakao Iwata and Mutsuo Harano and Heii Arai and Tohru Ohnuma and Ichiro Kusumi and Tsukasa Koyama and Hiroshi Yoneda and Yasuyuki Fukumaki and Hiroki Shibata and Sunao Kaneko and Hisashi Higuchi and Norio Yasui-Furukori and Yohtaro Numachi and Masanari Itokawa and Yujitno Okazaki",
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Arinami, T, Ohtsuki, T, Ishiguro, H, Ujike, H, Tanaka, Y, Morita, Y, Mineta, M, Takeichi, M, Yamada, S, Imamura, A, Ohara, K, Shibuya, H, Ohara, K, Suzuki, Y, Muratake, T, Kaneko, N, Someya, T, Inada, T, Yoshikawa, T, Toyota, T, Yamada, K, Kojima, T, Takahashi, S, Osamu, O, Shinkai, T, Nakamura, M, Fukuzako, H, Hashiguchi, T, Niwa, SI, Ueno, T, Tachikawa, H, Hori, T, Asada, T, Nanko, S, Kunugi, H, Hashimoto, R, Ozaki, N, Iwata, N, Harano, M, Arai, H, Ohnuma, T, Kusumi, I, Koyama, T, Yoneda, H, Fukumaki, Y, Shibata, H, Kaneko, S, Higuchi, H, Yasui-Furukori, N, Numachi, Y, Itokawa, M & Okazaki, Y 2005, 'Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p', American Journal of Human Genetics, vol. 77, no. 6, pp. 937-944. https://doi.org/10.1086/498122

Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p. / Arinami, Tadao; Ohtsuki, Tsuyuka; Ishiguro, Hiroki; Ujike, Hiroshi; Tanaka, Yuji; Morita, Yukitaka; Mineta, Mari; Takeichi, Masashi; Yamada, Shigeto; Imamura, Akira; Ohara, Koichi; Shibuya, Haruo; Ohara, Kenshiro; Suzuki, Yasuo; Muratake, Tatsuyuki; Kaneko, Naoshi; Someya, Toshiyuki; Inada, Toshiya; Yoshikawa, Takeo; Toyota, Tomoko; Yamada, Kazuo; Kojima, Takuya; Takahashi, Sakae; Osamu, Ohmori; Shinkai, Takahiro; Nakamura, Michiko; Fukuzako, Hiroshi; Hashiguchi, Tomo; Niwa, Shin Ich; Ueno, Takuya; Tachikawa, Hirokazu; Hori, Takafumi; Asada, Takashi; Nanko, Shinichiro; Kunugi, Hiroshi; Hashimoto, Ryota; Ozaki, Norio; Iwata, Nakao; Harano, Mutsuo; Arai, Heii; Ohnuma, Tohru; Kusumi, Ichiro; Koyama, Tsukasa; Yoneda, Hiroshi; Fukumaki, Yasuyuki; Shibata, Hiroki; Kaneko, Sunao; Higuchi, Hisashi; Yasui-Furukori, Norio; Numachi, Yohtaro; Itokawa, Masanari; Okazaki, Yujitno.

In: American Journal of Human Genetics, Vol. 77, No. 6, 01.01.2005, p. 937-944.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p

AU - Arinami, Tadao

AU - Ohtsuki, Tsuyuka

AU - Ishiguro, Hiroki

AU - Ujike, Hiroshi

AU - Tanaka, Yuji

AU - Morita, Yukitaka

AU - Mineta, Mari

AU - Takeichi, Masashi

AU - Yamada, Shigeto

AU - Imamura, Akira

AU - Ohara, Koichi

AU - Shibuya, Haruo

AU - Ohara, Kenshiro

AU - Suzuki, Yasuo

AU - Muratake, Tatsuyuki

AU - Kaneko, Naoshi

AU - Someya, Toshiyuki

AU - Inada, Toshiya

AU - Yoshikawa, Takeo

AU - Toyota, Tomoko

AU - Yamada, Kazuo

AU - Kojima, Takuya

AU - Takahashi, Sakae

AU - Osamu, Ohmori

AU - Shinkai, Takahiro

AU - Nakamura, Michiko

AU - Fukuzako, Hiroshi

AU - Hashiguchi, Tomo

AU - Niwa, Shin Ich

AU - Ueno, Takuya

AU - Tachikawa, Hirokazu

AU - Hori, Takafumi

AU - Asada, Takashi

AU - Nanko, Shinichiro

AU - Kunugi, Hiroshi

AU - Hashimoto, Ryota

AU - Ozaki, Norio

AU - Iwata, Nakao

AU - Harano, Mutsuo

AU - Arai, Heii

AU - Ohnuma, Tohru

AU - Kusumi, Ichiro

AU - Koyama, Tsukasa

AU - Yoneda, Hiroshi

AU - Fukumaki, Yasuyuki

AU - Shibata, Hiroki

AU - Kaneko, Sunao

AU - Higuchi, Hisashi

AU - Yasui-Furukori, Norio

AU - Numachi, Yohtaro

AU - Itokawa, Masanari

AU - Okazaki, Yujitno

PY - 2005/1/1

Y1 - 2005/1/1

N2 - The Japanese Schizophrenia Sib-Pair Linkage Group (JSSLG) is a multisite collaborative study group that was organized to create a national resource for affected sib pair (ASP) studies of schizophrenia in Japan. We used a high-density single-nucleotide-polymorphism (SNP) genotyping assay, the Illumina BeadArray linkage mapping panel (version 4) comprising 5,861 SNPs, to perform a genomewide linkage analysis of JSSLG samples comprising 236 Japanese families with 268 nonindependent ASPs with schizophrenia. All subjects were Japanese. Among these families, 122 families comprised the same subjects analyzed with short tandem repeat markers. All the probands and their siblings, with the exception of seven siblings with schizoaffective disorder, had schizophrenia. After excluding SNPs with high linkage disequilibrium, we found significant evidence of linkage of schizophrenia to chromosome 1p21.2-1p 13.2 (LOD = 3.39) and suggestive evidence of linkage to 14q11.2 (LOD = 2.87), 14q11.2-q13.2 (LOD = 2.33), and 20p12.1-p11.2 (LOD = 2.33). Although linkage to these regions has received little attention, these regions are included in or partially overlap the 10 regions reported by Lewis et al. that passed the two aggregate criteria of a meta-analysis. Results of the present study-which, to our knowledge, is the first genomewide analysis of schizophrenia in ASPs of a single Asian ethnicity that is comparable to the analyses done of ASPs of European descent-indicate the existence of schizophrenia susceptibility loci that are common to different ethnic groups but that likely have different ethnicity-specific effects.

AB - The Japanese Schizophrenia Sib-Pair Linkage Group (JSSLG) is a multisite collaborative study group that was organized to create a national resource for affected sib pair (ASP) studies of schizophrenia in Japan. We used a high-density single-nucleotide-polymorphism (SNP) genotyping assay, the Illumina BeadArray linkage mapping panel (version 4) comprising 5,861 SNPs, to perform a genomewide linkage analysis of JSSLG samples comprising 236 Japanese families with 268 nonindependent ASPs with schizophrenia. All subjects were Japanese. Among these families, 122 families comprised the same subjects analyzed with short tandem repeat markers. All the probands and their siblings, with the exception of seven siblings with schizoaffective disorder, had schizophrenia. After excluding SNPs with high linkage disequilibrium, we found significant evidence of linkage of schizophrenia to chromosome 1p21.2-1p 13.2 (LOD = 3.39) and suggestive evidence of linkage to 14q11.2 (LOD = 2.87), 14q11.2-q13.2 (LOD = 2.33), and 20p12.1-p11.2 (LOD = 2.33). Although linkage to these regions has received little attention, these regions are included in or partially overlap the 10 regions reported by Lewis et al. that passed the two aggregate criteria of a meta-analysis. Results of the present study-which, to our knowledge, is the first genomewide analysis of schizophrenia in ASPs of a single Asian ethnicity that is comparable to the analyses done of ASPs of European descent-indicate the existence of schizophrenia susceptibility loci that are common to different ethnic groups but that likely have different ethnicity-specific effects.

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