Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p

Tadao Arinami, Tsuyuka Ohtsuki, Hiroki Ishiguro, Hiroshi Ujike, Yuji Tanaka, Yukitaka Morita, Mari Mineta, Masashi Takeichi, Shigeto Yamada, Akira Imamura, Koichi Ohara, Haruo Shibuya, Kenshiro Ohara, Yasuo Suzuki, Tatsuyuki Muratake, Naoshi Kaneko, Toshiyuki Someya, Toshiya Inada, Takeo Yoshikawa, Tomoko ToyotaKazuo Yamada, Takuya Kojima, Sakae Takahashi, Ohmori Osamu, Takahiro Shinkai, Michiko Nakamura, Hiroshi Fukuzako, Tomo Hashiguchi, Shin Ich Niwa, Takuya Ueno, Hirokazu Tachikawa, Takafumi Hori, Takashi Asada, Shinichiro Nanko, Hiroshi Kunugi, Ryota Hashimoto, Norio Ozaki, Nakao Iwata, Mutsuo Harano, Heii Arai, Tohru Ohnuma, Ichiro Kusumi, Tsukasa Koyama, Hiroshi Yoneda, Yasuyuki Fukumaki, Hiroki Shibata, Sunao Kaneko, Hisashi Higuchi, Norio Yasui-Furukori, Yohtaro Numachi, Masanari Itokawa, Yujitno Okazaki

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Abstract

The Japanese Schizophrenia Sib-Pair Linkage Group (JSSLG) is a multisite collaborative study group that was organized to create a national resource for affected sib pair (ASP) studies of schizophrenia in Japan. We used a high-density single-nucleotide-polymorphism (SNP) genotyping assay, the Illumina BeadArray linkage mapping panel (version 4) comprising 5,861 SNPs, to perform a genomewide linkage analysis of JSSLG samples comprising 236 Japanese families with 268 nonindependent ASPs with schizophrenia. All subjects were Japanese. Among these families, 122 families comprised the same subjects analyzed with short tandem repeat markers. All the probands and their siblings, with the exception of seven siblings with schizoaffective disorder, had schizophrenia. After excluding SNPs with high linkage disequilibrium, we found significant evidence of linkage of schizophrenia to chromosome 1p21.2-1p 13.2 (LOD = 3.39) and suggestive evidence of linkage to 14q11.2 (LOD = 2.87), 14q11.2-q13.2 (LOD = 2.33), and 20p12.1-p11.2 (LOD = 2.33). Although linkage to these regions has received little attention, these regions are included in or partially overlap the 10 regions reported by Lewis et al. that passed the two aggregate criteria of a meta-analysis. Results of the present study-which, to our knowledge, is the first genomewide analysis of schizophrenia in ASPs of a single Asian ethnicity that is comparable to the analyses done of ASPs of European descent-indicate the existence of schizophrenia susceptibility loci that are common to different ethnic groups but that likely have different ethnicity-specific effects.

Original languageEnglish
Pages (from-to)937-944
Number of pages8
JournalAmerican Journal of Human Genetics
Volume77
Issue number6
DOIs
Publication statusPublished - 12-2005

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All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Arinami, T., Ohtsuki, T., Ishiguro, H., Ujike, H., Tanaka, Y., Morita, Y., Mineta, M., Takeichi, M., Yamada, S., Imamura, A., Ohara, K., Shibuya, H., Ohara, K., Suzuki, Y., Muratake, T., Kaneko, N., Someya, T., Inada, T., Yoshikawa, T., ... Okazaki, Y. (2005). Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p. American Journal of Human Genetics, 77(6), 937-944. https://doi.org/10.1086/498122