Genomic analysis of group A rotavirus G12P[8] including a new Japanese strain revealed evidence for intergenotypic recombination in VP7 and VP4 genes

Tung Phan; Tomihiko Ide; Satoshi Komoto; Pattara Khamrin; Ngan Thi Kim Pham; Shoko Okitsu; Koki Taniguchi; Shuichi Nishimura; Niwat Maneekarn; Satoshi Hayakawa; Hiroshi Ushijima

doi:10.1016/j.meegid.2020.104656

Genomic analysis of group A rotavirus G12P[8] including a new Japanese strain revealed evidence for intergenotypic recombination in VP7 and VP4 genes

Tung Phan
, Tomihiko Ide
, Satoshi Komoto
, Pattara Khamrin
, Ngan Thi Kim Pham
, Shoko Okitsu
, Koki Taniguchi
, Shuichi Nishimura
, Niwat Maneekarn
, Satoshi Hayakawa
, Hiroshi Ushijima

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Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Group A rotavirus is a leading cause of severe acute gastroenteritis worldwide. In this study, the first complete coding sequences of 11 RNA segments of human group A rotavirus G12P[8] in Japan were determined by an unbiased viral metagenomics. Its genomic constellation (VP7-VP4-VP6-VP1-VP2-VP3-NSP1-NSP2-NSP3-NSP4-NSP5 genes) was identified as G12-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1. When performing the genetic analysis, we discovered an intergenotypic recombination event in the pig group A rotavirus G12P[8] strain BUW-14-A008. The novel recombination was found between two different genotypes G12 and G3 in the VP7 gene, and P[8] and P[13] in the VP4 gene.

Original language	English
Article number	104656
Journal	Infection, Genetics and Evolution
Volume	87
DOIs	https://doi.org/10.1016/j.meegid.2020.104656
Publication status	Published - 01-2021

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Microbiology
Ecology, Evolution, Behavior and Systematics
Molecular Biology
Genetics
Microbiology (medical)
Infectious Diseases

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10.1016/j.meegid.2020.104656

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Phan, T., Ide, T., Komoto, S., Khamrin, P., Pham, N. T. K., Okitsu, S., Taniguchi, K., Nishimura, S., Maneekarn, N., Hayakawa, S., & Ushijima, H. (2021). Genomic analysis of group A rotavirus G12P[8] including a new Japanese strain revealed evidence for intergenotypic recombination in VP7 and VP4 genes. Infection, Genetics and Evolution, 87, Article 104656. https://doi.org/10.1016/j.meegid.2020.104656

@article{30a8fe952c4748c8b5ee81a2df8064cc,

title = "Genomic analysis of group A rotavirus G12P[8] including a new Japanese strain revealed evidence for intergenotypic recombination in VP7 and VP4 genes",

abstract = "Group A rotavirus is a leading cause of severe acute gastroenteritis worldwide. In this study, the first complete coding sequences of 11 RNA segments of human group A rotavirus G12P[8] in Japan were determined by an unbiased viral metagenomics. Its genomic constellation (VP7-VP4-VP6-VP1-VP2-VP3-NSP1-NSP2-NSP3-NSP4-NSP5 genes) was identified as G12-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1. When performing the genetic analysis, we discovered an intergenotypic recombination event in the pig group A rotavirus G12P[8] strain BUW-14-A008. The novel recombination was found between two different genotypes G12 and G3 in the VP7 gene, and P[8] and P[13] in the VP4 gene.",

keywords = "Genomic analysis, Intergenotype, Recombination, Rotavirus",

author = "Tung Phan and Tomihiko Ide and Satoshi Komoto and Pattara Khamrin and Pham, \{Ngan Thi Kim\} and Shoko Okitsu and Koki Taniguchi and Shuichi Nishimura and Niwat Maneekarn and Satoshi Hayakawa and Hiroshi Ushijima",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

year = "2021",

month = jan,

doi = "10.1016/j.meegid.2020.104656",

language = "English",

volume = "87",

journal = "Infection, Genetics and Evolution",

issn = "1567-1348",

publisher = "Elsevier B.V.",

}

Phan, T, Ide, T, Komoto, S, Khamrin, P, Pham, NTK, Okitsu, S, Taniguchi, K, Nishimura, S, Maneekarn, N, Hayakawa, S & Ushijima, H 2021, 'Genomic analysis of group A rotavirus G12P[8] including a new Japanese strain revealed evidence for intergenotypic recombination in VP7 and VP4 genes', Infection, Genetics and Evolution, vol. 87, 104656. https://doi.org/10.1016/j.meegid.2020.104656

TY - JOUR

T1 - Genomic analysis of group A rotavirus G12P[8] including a new Japanese strain revealed evidence for intergenotypic recombination in VP7 and VP4 genes

AU - Phan, Tung

AU - Ide, Tomihiko

AU - Komoto, Satoshi

AU - Khamrin, Pattara

AU - Pham, Ngan Thi Kim

AU - Okitsu, Shoko

AU - Taniguchi, Koki

AU - Nishimura, Shuichi

AU - Maneekarn, Niwat

AU - Hayakawa, Satoshi

AU - Ushijima, Hiroshi

PY - 2021/1

Y1 - 2021/1

N2 - Group A rotavirus is a leading cause of severe acute gastroenteritis worldwide. In this study, the first complete coding sequences of 11 RNA segments of human group A rotavirus G12P[8] in Japan were determined by an unbiased viral metagenomics. Its genomic constellation (VP7-VP4-VP6-VP1-VP2-VP3-NSP1-NSP2-NSP3-NSP4-NSP5 genes) was identified as G12-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1. When performing the genetic analysis, we discovered an intergenotypic recombination event in the pig group A rotavirus G12P[8] strain BUW-14-A008. The novel recombination was found between two different genotypes G12 and G3 in the VP7 gene, and P[8] and P[13] in the VP4 gene.

AB - Group A rotavirus is a leading cause of severe acute gastroenteritis worldwide. In this study, the first complete coding sequences of 11 RNA segments of human group A rotavirus G12P[8] in Japan were determined by an unbiased viral metagenomics. Its genomic constellation (VP7-VP4-VP6-VP1-VP2-VP3-NSP1-NSP2-NSP3-NSP4-NSP5 genes) was identified as G12-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1. When performing the genetic analysis, we discovered an intergenotypic recombination event in the pig group A rotavirus G12P[8] strain BUW-14-A008. The novel recombination was found between two different genotypes G12 and G3 in the VP7 gene, and P[8] and P[13] in the VP4 gene.

KW - Genomic analysis

KW - Intergenotype

KW - Recombination

KW - Rotavirus

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UR - https://www.scopus.com/pages/publications/85097467714#tab=citedBy

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DO - 10.1016/j.meegid.2020.104656

M3 - Article

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AN - SCOPUS:85097467714

SN - 1567-1348

VL - 87

JO - Infection, Genetics and Evolution

JF - Infection, Genetics and Evolution

M1 - 104656

ER -

Genomic analysis of group A rotavirus G12P[8] including a new Japanese strain revealed evidence for intergenotypic recombination in VP7 and VP4 genes

Abstract

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