Genomic approaches to research in pulmonary hypertension

Mark W. Geraci, Bifeng Gao, Yasushi Hoshikawa, Michael E. Yeager, Rubin M. Tuder, Norbert F. Voelkel

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)


Genomics, or the study of genes and their function, is a burgeoning field with many new technologies. In the present review, we explore the application of genomic approaches to the study of pulmonary hypertension (PH). Candidate genes, important to the pathobiology of the disease, have been investigated. Rodent models enable the manipulation of selected genes, either by transgenesis or targeted disruption. Mutational analysis of genes in the transforming growth factor-β family have proven pivotal in both familial and sporadic forms of primary PH. Finally, microarray gene expression analysis is a robust molecular tool to aid in delineating the pathobiology of this disease.

Original languageEnglish
Pages (from-to)210-215
Number of pages6
JournalRespiratory Research
Issue number4
Publication statusPublished - 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine


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