Genomic characterization of a novel G3P[10] rotavirus strain from a diarrheic child in Thailand: Evidence for bat-to-human zoonotic transmission

Satoshi Komoto, Ratana Tacharoenmuang, Ratigorn Guntapong, Sompong Upachai, Phakapun Singchai, Tomihiko Ide, Saori Fukuda, Riona Hatazawa, Karun Sutthiwarakom, Santip Kongjorn, Napa Onvimala, Tipsuda Luechakham, Busarawan Sriwanthana, Takayuki Murata, Ballang Uppapong, Koki Taniguchi

Research output: Contribution to journalArticlepeer-review

Abstract

An unusual rotavirus strain with the G3P[10] genotype (RVA/Human-wt/THA/MS2015-1-0001/2015/G3P[10]) was identified in a stool sample from a hospitalized child aged 11 months with severe gastroenteritis in Thailand. In the current study, we sequenced and characterized the full genome of strain MS2015-1-0001. On full-genomic analysis, strain MS2015-1-0001 exhibited the following genotype configuration: G3-P[10]-I8-R3-C3-M3-A9-N3-T3-E3-H6, which is identical or closely related to those of bat and bat-like rotavirus strains (MYAS33-like). Furthermore, phylogenetic analysis revealed that all 11 genes of strain MS2015-1-0001 appeared to be of bat origin. Our findings provide evidence for bat-to-human interspecies transmission of rotaviruses and important insights into dynamic interactions between human and bat rotavirus strains.

Original languageEnglish
Article number104667
JournalInfection, Genetics and Evolution
Volume87
DOIs
Publication statusPublished - 01-2021

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Microbiology (medical)
  • Infectious Diseases

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