TY - JOUR
T1 - Genomic organization and fine-mapping of the human leucine zipper-bearing kinase (LZK) gene
AU - Ikeda, A.
AU - Sakuma, H.
AU - Masaki, M.
AU - Kozutsumi, Y.
AU - Oka, S.
AU - Inazawa, J.
AU - Kawasaki, T.
PY - 2002/4
Y1 - 2002/4
N2 - Leucine zipper-bearing kinase (LZK) is a new member of the mixed lineage protein kinase family. We previously cloned a cDNA encoding LZK from a human cerebellum cDNA library. The following studies indicated that LZK serves as a MAPKKK in the JNK/SAPK pathway in cells, and a scaffold protein, JIP-1, enhances LZK-induced JNK/SAPK pathway activation via physical association. Here we report characterization of the gene structure and fine chromosomal mapping of the human LZK gene. Polymerase chain-reaction (PCR) studies indicated that the human LZK coding sequence is composed of 13 exons, and that all the splice acceptor and donor sequences obey the GT-AG rule. Chromosomal localization studies involving FISH mapping demonstrated that the human LZK gene is located at 3q27.
AB - Leucine zipper-bearing kinase (LZK) is a new member of the mixed lineage protein kinase family. We previously cloned a cDNA encoding LZK from a human cerebellum cDNA library. The following studies indicated that LZK serves as a MAPKKK in the JNK/SAPK pathway in cells, and a scaffold protein, JIP-1, enhances LZK-induced JNK/SAPK pathway activation via physical association. Here we report characterization of the gene structure and fine chromosomal mapping of the human LZK gene. Polymerase chain-reaction (PCR) studies indicated that the human LZK coding sequence is composed of 13 exons, and that all the splice acceptor and donor sequences obey the GT-AG rule. Chromosomal localization studies involving FISH mapping demonstrated that the human LZK gene is located at 3q27.
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U2 - 10.1080/10258140290027243
DO - 10.1080/10258140290027243
M3 - Article
C2 - 12186766
AN - SCOPUS:0036554462
SN - 1025-8140
VL - 6
SP - 113
EP - 116
JO - Journal of Biochemistry, Molecular Biology and Biophysics
JF - Journal of Biochemistry, Molecular Biology and Biophysics
IS - 2
ER -