Geraniinic acid derivative from the leaves of Phyllanthus reticulatus

Nuch Pojchaijongdee, Uthai Sotanaphun, Siripan Limsirichaikul, Onoomar Poobrasert

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15 Citations (Scopus)


Chemical constituents as well as cytotoxic and insecticidal activity of the crude methanol extract from the leaves of Phyllanthus reticulatus Poir. (Euphorbiaceae) were investigated. (5R*,6R*)-4,6-Dimethoxycarbonyl- 5-[2′,3′,4′-trihydroxy-6′-(methoxycarbonyl) phenyl]-5,6-dihydro-2H-pyran-2-one (1) along with 3,4,3′-tri-O- methylellagic acid, and methyl gallate were isolated from the dichloromethane extract. Determination of their structures was based on spectroscopic analysis. Compound 1 possessed a very weak insecticidal activity against Spodoptera frugiperda (Sf9) with an IC 50 value of 27.27μg/mL.

Original languageEnglish
Pages (from-to)740-744
Number of pages5
JournalPharmaceutical Biology
Issue number7
Publication statusPublished - 07-2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine


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