Geraniinic acid derivative from the leaves of Phyllanthus reticulatus

Nuch Pojchaijongdee; Uthai Sotanaphun; Siripan Limsirichaikul; Onoomar Poobrasert

doi:10.3109/13880200903273898

Geraniinic acid derivative from the leaves of Phyllanthus reticulatus

Nuch Pojchaijongdee, Uthai Sotanaphun, Siripan Limsirichaikul, Onoomar Poobrasert

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Chemical constituents as well as cytotoxic and insecticidal activity of the crude methanol extract from the leaves of Phyllanthus reticulatus Poir. (Euphorbiaceae) were investigated. (5R*,6R*)-4,6-Dimethoxycarbonyl- 5-[2′,3′,4′-trihydroxy-6′-(methoxycarbonyl) phenyl]-5,6-dihydro-2H-pyran-2-one (1) along with 3,4,3′-tri-O- methylellagic acid, and methyl gallate were isolated from the dichloromethane extract. Determination of their structures was based on spectroscopic analysis. Compound 1 possessed a very weak insecticidal activity against Spodoptera frugiperda (Sf9) with an IC ₅₀ value of 27.27μg/mL.

Original language	English
Pages (from-to)	740-744
Number of pages	5
Journal	Pharmaceutical Biology
Volume	48
Issue number	7
DOIs	https://doi.org/10.3109/13880200903273898
Publication status	Published - 07-2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine

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abstract = "Chemical constituents as well as cytotoxic and insecticidal activity of the crude methanol extract from the leaves of Phyllanthus reticulatus Poir. (Euphorbiaceae) were investigated. (5R*,6R*)-4,6-Dimethoxycarbonyl- 5-[2′,3′,4′-trihydroxy-6′-(methoxycarbonyl) phenyl]-5,6-dihydro-2H-pyran-2-one (1) along with 3,4,3′-tri-O- methylellagic acid, and methyl gallate were isolated from the dichloromethane extract. Determination of their structures was based on spectroscopic analysis. Compound 1 possessed a very weak insecticidal activity against Spodoptera frugiperda (Sf9) with an IC 50 value of 27.27μg/mL.",

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AU - Pojchaijongdee, Nuch

AU - Sotanaphun, Uthai

AU - Limsirichaikul, Siripan

AU - Poobrasert, Onoomar

PY - 2010/7

Y1 - 2010/7

N2 - Chemical constituents as well as cytotoxic and insecticidal activity of the crude methanol extract from the leaves of Phyllanthus reticulatus Poir. (Euphorbiaceae) were investigated. (5R*,6R*)-4,6-Dimethoxycarbonyl- 5-[2′,3′,4′-trihydroxy-6′-(methoxycarbonyl) phenyl]-5,6-dihydro-2H-pyran-2-one (1) along with 3,4,3′-tri-O- methylellagic acid, and methyl gallate were isolated from the dichloromethane extract. Determination of their structures was based on spectroscopic analysis. Compound 1 possessed a very weak insecticidal activity against Spodoptera frugiperda (Sf9) with an IC 50 value of 27.27μg/mL.

AB - Chemical constituents as well as cytotoxic and insecticidal activity of the crude methanol extract from the leaves of Phyllanthus reticulatus Poir. (Euphorbiaceae) were investigated. (5R*,6R*)-4,6-Dimethoxycarbonyl- 5-[2′,3′,4′-trihydroxy-6′-(methoxycarbonyl) phenyl]-5,6-dihydro-2H-pyran-2-one (1) along with 3,4,3′-tri-O- methylellagic acid, and methyl gallate were isolated from the dichloromethane extract. Determination of their structures was based on spectroscopic analysis. Compound 1 possessed a very weak insecticidal activity against Spodoptera frugiperda (Sf9) with an IC 50 value of 27.27μg/mL.

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Geraniinic acid derivative from the leaves of Phyllanthus reticulatus

Abstract

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