Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms

Kazuhiro Ishiguro, Takafumi Ando, Osamu Maeda, Naoki Ohmiya, Yasumasa Niwa, Kenji Kadomatsu, Hidemi Goto

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

Ginger has been used throughout the world as spice, food and traditional herb. We found that 6-gingerol, a phenolic alkanone isolated from ginger, enhanced the TRAIL-induced viability reduction of gastric cancer cells while 6-gingerol alone affected viability only slightly. 6-Gingerol facilitated TRAIL-induced apoptosis by increasing TRAIL-induced caspase-3/7 activation. 6-Gingerol was shown to down-regulate the expression of cIAP1, which suppresses caspase-3/7 activity, by inhibiting TRAIL-induced NF-κB activation. As 6-shogaol has a chemical structure similar to 6-gingerol, we also assessed the effect of 6-shogaol on the viability of gastric cancer cells. Unlike 6-gingerol, 6-shogaol alone reduced the viability of gastric cancer cells. 6-Shogaol was shown to damage microtubules and induce mitotic arrest. These findings indicate for the first time that in gastric cancer cells, 6-gingerol enhances TRAIL-induced viability reduction by inhibiting TRAIL-induced NF-κB activation while 6-shogaol alone reduces viability by damaging microtubules.

Original languageEnglish
Pages (from-to)218-223
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume362
Issue number1
DOIs
Publication statusPublished - 12-10-2007

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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