Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms

Kazuhiro Ishiguro, Takafumi Ando, Osamu Maeda, Naoki Omiya, Yasumasa Niwa, Kenji Kadomatsu, Hidemi Goto

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Ginger has been used throughout the world as spice, food and traditional herb. We found that 6-gingerol, a phenolic alkanone isolated from ginger, enhanced the TRAIL-induced viability reduction of gastric cancer cells while 6-gingerol alone affected viability only slightly. 6-Gingerol facilitated TRAIL-induced apoptosis by increasing TRAIL-induced caspase-3/7 activation. 6-Gingerol was shown to down-regulate the expression of cIAP1, which suppresses caspase-3/7 activity, by inhibiting TRAIL-induced NF-κB activation. As 6-shogaol has a chemical structure similar to 6-gingerol, we also assessed the effect of 6-shogaol on the viability of gastric cancer cells. Unlike 6-gingerol, 6-shogaol alone reduced the viability of gastric cancer cells. 6-Shogaol was shown to damage microtubules and induce mitotic arrest. These findings indicate for the first time that in gastric cancer cells, 6-gingerol enhances TRAIL-induced viability reduction by inhibiting TRAIL-induced NF-κB activation while 6-shogaol alone reduces viability by damaging microtubules.

Original languageEnglish
Pages (from-to)218-223
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume362
Issue number1
DOIs
Publication statusPublished - 12-10-2007
Externally publishedYes

Fingerprint

Ginger
Stomach Neoplasms
Cells
Caspase 7
Chemical activation
Microtubules
Caspase 3
Spices
gingerol
Down-Regulation
shogaol
Apoptosis
Food

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Ishiguro, Kazuhiro ; Ando, Takafumi ; Maeda, Osamu ; Omiya, Naoki ; Niwa, Yasumasa ; Kadomatsu, Kenji ; Goto, Hidemi. / Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms. In: Biochemical and Biophysical Research Communications. 2007 ; Vol. 362, No. 1. pp. 218-223.
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Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms. / Ishiguro, Kazuhiro; Ando, Takafumi; Maeda, Osamu; Omiya, Naoki; Niwa, Yasumasa; Kadomatsu, Kenji; Goto, Hidemi.

In: Biochemical and Biophysical Research Communications, Vol. 362, No. 1, 12.10.2007, p. 218-223.

Research output: Contribution to journalArticle

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