Glioblastoma Cell Lines Display Different Sensitivities to Plasma-Activated Medium

Hiromasa Tanaka; Masaaki Mizuno; Kenji Ishikawa; Keigo Takeda; Hiroshi Hashizume; Kae Nakamura; Fumi Utsumi; Hiroaki Kajiyama; Yasumasa Okazaki; Shinya Toyokuni; Shinichi Akiyama; Shoichi Maruyama; Fumitaka Kikkawa; Masaru Hori

doi:10.1109/trpms.2017.2721973

Glioblastoma Cell Lines Display Different Sensitivities to Plasma-Activated Medium

Hiromasa Tanaka
, Masaaki Mizuno
, Kenji Ishikawa
, Keigo Takeda
, Hiroshi Hashizume
, Kae Nakamura
, Fumi Utsumi
, Hiroaki Kajiyama
, Yasumasa Okazaki
, Shinya Toyokuni
, Shinichi Akiyama
, Shoichi Maruyama
, Fumitaka Kikkawa
, Masaru Hori

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Plasma-activated medium (PAM) is a novel chemotherapy that induces reactive oxygen species (ROS) and cell death in a wide range of cancer cell types, suggesting that PAM may be a promising therapeutic option for cancer treatment. However, dose response experiments suggest that PAM sensitivity is cell line specific. We examined the sensitivities of three glioblastoma cell lines to PAM, and found a wide variation in cell killing that was linked to differences in PAM induced ROS and apoptosis. These results indicate that the PAM sensitivity of glioblastoma cells, and potentially cancer cells more generally, is heterogeneous and likely to be dependent on the regulation of apoptosis and antioxidant pathways in target cells.

Original language	English
Pages (from-to)	99-102
Number of pages	4
Journal	IEEE Transactions on Radiation and Plasma Medical Sciences
Volume	2
Issue number	2
DOIs	https://doi.org/10.1109/trpms.2017.2721973
Publication status	Published - 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Atomic and Molecular Physics, and Optics
Instrumentation
Radiology Nuclear Medicine and imaging

Access to Document

10.1109/trpms.2017.2721973

Cite this

Tanaka, H., Mizuno, M., Ishikawa, K., Takeda, K., Hashizume, H., Nakamura, K., Utsumi, F., Kajiyama, H., Okazaki, Y., Toyokuni, S., Akiyama, S., Maruyama, S., Kikkawa, F., & Hori, M. (2018). Glioblastoma Cell Lines Display Different Sensitivities to Plasma-Activated Medium. IEEE Transactions on Radiation and Plasma Medical Sciences, 2(2), 99-102. https://doi.org/10.1109/trpms.2017.2721973

@article{c9f3d8273a8640438d7faa8635c59241,

title = "Glioblastoma Cell Lines Display Different Sensitivities to Plasma-Activated Medium",

abstract = "Plasma-activated medium (PAM) is a novel chemotherapy that induces reactive oxygen species (ROS) and cell death in a wide range of cancer cell types, suggesting that PAM may be a promising therapeutic option for cancer treatment. However, dose response experiments suggest that PAM sensitivity is cell line specific. We examined the sensitivities of three glioblastoma cell lines to PAM, and found a wide variation in cell killing that was linked to differences in PAM induced ROS and apoptosis. These results indicate that the PAM sensitivity of glioblastoma cells, and potentially cancer cells more generally, is heterogeneous and likely to be dependent on the regulation of apoptosis and antioxidant pathways in target cells.",

author = "Hiromasa Tanaka and Masaaki Mizuno and Kenji Ishikawa and Keigo Takeda and Hiroshi Hashizume and Kae Nakamura and Fumi Utsumi and Hiroaki Kajiyama and Yasumasa Okazaki and Shinya Toyokuni and Shinichi Akiyama and Shoichi Maruyama and Fumitaka Kikkawa and Masaru Hori",

note = "Publisher Copyright: {\textcopyright} 2017 IEEE.",

year = "2018",

doi = "10.1109/trpms.2017.2721973",

language = "English",

volume = "2",

pages = "99--102",

journal = "IEEE Transactions on Radiation and Plasma Medical Sciences",

issn = "2469-7311",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

number = "2",

}

Tanaka, H, Mizuno, M, Ishikawa, K, Takeda, K, Hashizume, H, Nakamura, K, Utsumi, F, Kajiyama, H, Okazaki, Y, Toyokuni, S, Akiyama, S, Maruyama, S, Kikkawa, F & Hori, M 2018, 'Glioblastoma Cell Lines Display Different Sensitivities to Plasma-Activated Medium', IEEE Transactions on Radiation and Plasma Medical Sciences, vol. 2, no. 2, pp. 99-102. https://doi.org/10.1109/trpms.2017.2721973

TY - JOUR

T1 - Glioblastoma Cell Lines Display Different Sensitivities to Plasma-Activated Medium

AU - Tanaka, Hiromasa

AU - Mizuno, Masaaki

AU - Ishikawa, Kenji

AU - Takeda, Keigo

AU - Hashizume, Hiroshi

AU - Nakamura, Kae

AU - Utsumi, Fumi

AU - Kajiyama, Hiroaki

AU - Okazaki, Yasumasa

AU - Toyokuni, Shinya

AU - Akiyama, Shinichi

AU - Maruyama, Shoichi

AU - Kikkawa, Fumitaka

AU - Hori, Masaru

PY - 2018

Y1 - 2018

N2 - Plasma-activated medium (PAM) is a novel chemotherapy that induces reactive oxygen species (ROS) and cell death in a wide range of cancer cell types, suggesting that PAM may be a promising therapeutic option for cancer treatment. However, dose response experiments suggest that PAM sensitivity is cell line specific. We examined the sensitivities of three glioblastoma cell lines to PAM, and found a wide variation in cell killing that was linked to differences in PAM induced ROS and apoptosis. These results indicate that the PAM sensitivity of glioblastoma cells, and potentially cancer cells more generally, is heterogeneous and likely to be dependent on the regulation of apoptosis and antioxidant pathways in target cells.

AB - Plasma-activated medium (PAM) is a novel chemotherapy that induces reactive oxygen species (ROS) and cell death in a wide range of cancer cell types, suggesting that PAM may be a promising therapeutic option for cancer treatment. However, dose response experiments suggest that PAM sensitivity is cell line specific. We examined the sensitivities of three glioblastoma cell lines to PAM, and found a wide variation in cell killing that was linked to differences in PAM induced ROS and apoptosis. These results indicate that the PAM sensitivity of glioblastoma cells, and potentially cancer cells more generally, is heterogeneous and likely to be dependent on the regulation of apoptosis and antioxidant pathways in target cells.

UR - https://www.scopus.com/pages/publications/85068568819

UR - https://www.scopus.com/pages/publications/85068568819#tab=citedBy

U2 - 10.1109/trpms.2017.2721973

DO - 10.1109/trpms.2017.2721973

M3 - Article

AN - SCOPUS:85068568819

SN - 2469-7311

VL - 2

SP - 99

EP - 102

JO - IEEE Transactions on Radiation and Plasma Medical Sciences

JF - IEEE Transactions on Radiation and Plasma Medical Sciences

IS - 2

ER -

Glioblastoma Cell Lines Display Different Sensitivities to Plasma-Activated Medium

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this