Global implementation of genomic medicine: We are not alone

Teri A. Manolio, Marc Abramowicz, Fahd Al-Mulla, Warwick Anderson, Rudi Balling, Adam C. Berger, Steven Bleyl, Aravinda Chakravarti, Wasun Chantratita, Rex L. Chisholm, Vajira H.W. Dissanayake, Michael Dunn, Victor J. Dzau, Bok Ghee Han, Tim Hubbard, Anne Kolbe, Bruce Korf, Michiaki Kubo, Paul Lasko, Erkki LeegoSurakameth Mahasirimongkol, Partha P. Majumdar, Gert Matthijs, Howard L. McLeod, Andres Metspalu, Pierre Meulien, Satoru Miyano, Yaakov Naparstek, P. Pearl O'Rourke, George P. Patrinos, Heidi L. Rehm, Mary V. Relling, Gad Rennert, Laura Lyman Rodriguez, Dan M. Roden, Alan R. Shuldiner, Sukdeb Sinha, Patrick Tan, Mats Ulfendahl, Robyn Ward, Marc S. Williams, John E.L. Wong, Eric D. Green, Geofrey S. Ginsburg

Research output: Contribution to journalReview article

76 Citations (Scopus)

Abstract

Around the world, innovative genomic-medicine programs capitalize on singular capabilities arising from local health care systems, cultural or political milieus, and unusual selected risk alleles or disease burdens. Such individual eforts might beneft from the sharing of approaches and lessons learned in other locales. The U.S. National Human Genome Research Institute and the National Academy of Medicine recently brought together 25 of these groups to compare projects, to examine the current state of implementation and desired near-term capabilities, and to identify opportunities for collaboration that promote the responsible practice of genomic medicine. Eforts to coalesce these groups around concrete but compelling signature projects should accelerate the responsible implementation of genomic medicine in eforts to improve clinical care worldwide.

Original languageEnglish
Article number290ps13
JournalScience Translational Medicine
Volume7
Issue number290
DOIs
Publication statusPublished - 03-06-2015

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Medicine
National Human Genome Research Institute (U.S.)
Alleles
Delivery of Health Care

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Manolio, T. A., Abramowicz, M., Al-Mulla, F., Anderson, W., Balling, R., Berger, A. C., ... Ginsburg, G. S. (2015). Global implementation of genomic medicine: We are not alone. Science Translational Medicine, 7(290), [290ps13]. https://doi.org/10.1126/scitranslmed.aab0194
Manolio, Teri A. ; Abramowicz, Marc ; Al-Mulla, Fahd ; Anderson, Warwick ; Balling, Rudi ; Berger, Adam C. ; Bleyl, Steven ; Chakravarti, Aravinda ; Chantratita, Wasun ; Chisholm, Rex L. ; Dissanayake, Vajira H.W. ; Dunn, Michael ; Dzau, Victor J. ; Han, Bok Ghee ; Hubbard, Tim ; Kolbe, Anne ; Korf, Bruce ; Kubo, Michiaki ; Lasko, Paul ; Leego, Erkki ; Mahasirimongkol, Surakameth ; Majumdar, Partha P. ; Matthijs, Gert ; McLeod, Howard L. ; Metspalu, Andres ; Meulien, Pierre ; Miyano, Satoru ; Naparstek, Yaakov ; O'Rourke, P. Pearl ; Patrinos, George P. ; Rehm, Heidi L. ; Relling, Mary V. ; Rennert, Gad ; Rodriguez, Laura Lyman ; Roden, Dan M. ; Shuldiner, Alan R. ; Sinha, Sukdeb ; Tan, Patrick ; Ulfendahl, Mats ; Ward, Robyn ; Williams, Marc S. ; Wong, John E.L. ; Green, Eric D. ; Ginsburg, Geofrey S. / Global implementation of genomic medicine : We are not alone. In: Science Translational Medicine. 2015 ; Vol. 7, No. 290.
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abstract = "Around the world, innovative genomic-medicine programs capitalize on singular capabilities arising from local health care systems, cultural or political milieus, and unusual selected risk alleles or disease burdens. Such individual eforts might beneft from the sharing of approaches and lessons learned in other locales. The U.S. National Human Genome Research Institute and the National Academy of Medicine recently brought together 25 of these groups to compare projects, to examine the current state of implementation and desired near-term capabilities, and to identify opportunities for collaboration that promote the responsible practice of genomic medicine. Eforts to coalesce these groups around concrete but compelling signature projects should accelerate the responsible implementation of genomic medicine in eforts to improve clinical care worldwide.",
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Manolio, TA, Abramowicz, M, Al-Mulla, F, Anderson, W, Balling, R, Berger, AC, Bleyl, S, Chakravarti, A, Chantratita, W, Chisholm, RL, Dissanayake, VHW, Dunn, M, Dzau, VJ, Han, BG, Hubbard, T, Kolbe, A, Korf, B, Kubo, M, Lasko, P, Leego, E, Mahasirimongkol, S, Majumdar, PP, Matthijs, G, McLeod, HL, Metspalu, A, Meulien, P, Miyano, S, Naparstek, Y, O'Rourke, PP, Patrinos, GP, Rehm, HL, Relling, MV, Rennert, G, Rodriguez, LL, Roden, DM, Shuldiner, AR, Sinha, S, Tan, P, Ulfendahl, M, Ward, R, Williams, MS, Wong, JEL, Green, ED & Ginsburg, GS 2015, 'Global implementation of genomic medicine: We are not alone', Science Translational Medicine, vol. 7, no. 290, 290ps13. https://doi.org/10.1126/scitranslmed.aab0194

Global implementation of genomic medicine : We are not alone. / Manolio, Teri A.; Abramowicz, Marc; Al-Mulla, Fahd; Anderson, Warwick; Balling, Rudi; Berger, Adam C.; Bleyl, Steven; Chakravarti, Aravinda; Chantratita, Wasun; Chisholm, Rex L.; Dissanayake, Vajira H.W.; Dunn, Michael; Dzau, Victor J.; Han, Bok Ghee; Hubbard, Tim; Kolbe, Anne; Korf, Bruce; Kubo, Michiaki; Lasko, Paul; Leego, Erkki; Mahasirimongkol, Surakameth; Majumdar, Partha P.; Matthijs, Gert; McLeod, Howard L.; Metspalu, Andres; Meulien, Pierre; Miyano, Satoru; Naparstek, Yaakov; O'Rourke, P. Pearl; Patrinos, George P.; Rehm, Heidi L.; Relling, Mary V.; Rennert, Gad; Rodriguez, Laura Lyman; Roden, Dan M.; Shuldiner, Alan R.; Sinha, Sukdeb; Tan, Patrick; Ulfendahl, Mats; Ward, Robyn; Williams, Marc S.; Wong, John E.L.; Green, Eric D.; Ginsburg, Geofrey S.

In: Science Translational Medicine, Vol. 7, No. 290, 290ps13, 03.06.2015.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Global implementation of genomic medicine

T2 - We are not alone

AU - Manolio, Teri A.

AU - Abramowicz, Marc

AU - Al-Mulla, Fahd

AU - Anderson, Warwick

AU - Balling, Rudi

AU - Berger, Adam C.

AU - Bleyl, Steven

AU - Chakravarti, Aravinda

AU - Chantratita, Wasun

AU - Chisholm, Rex L.

AU - Dissanayake, Vajira H.W.

AU - Dunn, Michael

AU - Dzau, Victor J.

AU - Han, Bok Ghee

AU - Hubbard, Tim

AU - Kolbe, Anne

AU - Korf, Bruce

AU - Kubo, Michiaki

AU - Lasko, Paul

AU - Leego, Erkki

AU - Mahasirimongkol, Surakameth

AU - Majumdar, Partha P.

AU - Matthijs, Gert

AU - McLeod, Howard L.

AU - Metspalu, Andres

AU - Meulien, Pierre

AU - Miyano, Satoru

AU - Naparstek, Yaakov

AU - O'Rourke, P. Pearl

AU - Patrinos, George P.

AU - Rehm, Heidi L.

AU - Relling, Mary V.

AU - Rennert, Gad

AU - Rodriguez, Laura Lyman

AU - Roden, Dan M.

AU - Shuldiner, Alan R.

AU - Sinha, Sukdeb

AU - Tan, Patrick

AU - Ulfendahl, Mats

AU - Ward, Robyn

AU - Williams, Marc S.

AU - Wong, John E.L.

AU - Green, Eric D.

AU - Ginsburg, Geofrey S.

PY - 2015/6/3

Y1 - 2015/6/3

N2 - Around the world, innovative genomic-medicine programs capitalize on singular capabilities arising from local health care systems, cultural or political milieus, and unusual selected risk alleles or disease burdens. Such individual eforts might beneft from the sharing of approaches and lessons learned in other locales. The U.S. National Human Genome Research Institute and the National Academy of Medicine recently brought together 25 of these groups to compare projects, to examine the current state of implementation and desired near-term capabilities, and to identify opportunities for collaboration that promote the responsible practice of genomic medicine. Eforts to coalesce these groups around concrete but compelling signature projects should accelerate the responsible implementation of genomic medicine in eforts to improve clinical care worldwide.

AB - Around the world, innovative genomic-medicine programs capitalize on singular capabilities arising from local health care systems, cultural or political milieus, and unusual selected risk alleles or disease burdens. Such individual eforts might beneft from the sharing of approaches and lessons learned in other locales. The U.S. National Human Genome Research Institute and the National Academy of Medicine recently brought together 25 of these groups to compare projects, to examine the current state of implementation and desired near-term capabilities, and to identify opportunities for collaboration that promote the responsible practice of genomic medicine. Eforts to coalesce these groups around concrete but compelling signature projects should accelerate the responsible implementation of genomic medicine in eforts to improve clinical care worldwide.

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UR - http://www.scopus.com/inward/citedby.url?scp=84930433702&partnerID=8YFLogxK

U2 - 10.1126/scitranslmed.aab0194

DO - 10.1126/scitranslmed.aab0194

M3 - Review article

C2 - 26041702

AN - SCOPUS:84930433702

VL - 7

JO - Science Translational Medicine

JF - Science Translational Medicine

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Manolio TA, Abramowicz M, Al-Mulla F, Anderson W, Balling R, Berger AC et al. Global implementation of genomic medicine: We are not alone. Science Translational Medicine. 2015 Jun 3;7(290). 290ps13. https://doi.org/10.1126/scitranslmed.aab0194