Glomerular CD8+ cells predict progression of childhood IgA nephropathy

T. Watanabe, H. Kawachi, Y. Ikezumi, T. Yanagihara, Y. Oda, F. Shimizu

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Abstract

The aim of this study was to evaluate whether the infiltrating T-lymphocyte can be a predictor in the disease progression of IgA nephropathy (IgAN). Twenty children with IgAN, followed for more than 5 years, were divided into progressive (n=5) and non-progressive groups (n=15). We assessed glomerular and interstitial infiltration of T-lymphocytes (CD4+ and CD8+ cells) and expression of α-smooth muscle actin (α-SMA) and transforming growth factor- β (TGF- β) using an indirect immunofluorescence method on the renal biopsies. We analyzed their relationship to the degree of proteinuria, histological changes, and prognosis. The number of CD8+ cells in glomeruli and in interstitium was higher in the progressive group than in the non-progressive group. The glomerular α-SMA staining was more intensive in the progressive group than in the non-progressive group. Urinary protein and the degree of histological changes were also higher in the progressive group than in the non-progressive group. Among these markers, the number of glomerular CD8+ cells was the most apparent difference between the two groups. In conclusion, these results indicate that the number of glomerular CD8+ cells is the most sensitive predictor of disease progression in childhood IgAN.

Original languageEnglish
Pages (from-to)561-567
Number of pages7
JournalPediatric Nephrology
Volume16
Issue number7
DOIs
Publication statusPublished - 01-01-2001

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All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Cite this

Watanabe, T., Kawachi, H., Ikezumi, Y., Yanagihara, T., Oda, Y., & Shimizu, F. (2001). Glomerular CD8+ cells predict progression of childhood IgA nephropathy. Pediatric Nephrology, 16(7), 561-567. https://doi.org/10.1007/s004670100605