Glomerular density and volume in renal biopsy specimens of children with proteinuria relative to preterm birth and gestational age

Kentaro Koike, Yohei Ikezumi, Nobuo Tsuboi, Go Kanzaki, Kotaro Haruhara, Yusuke Okabayashi, Takaya Sasaki, Makoto Ogura, Akihiko Saitoh, Takashi Yokoo

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Abstract

Background and objectives A low total nephron number, which is associated with low birth weight (LBW), may indicate increased susceptibility to early-onset renal diseases in children. However, few studies have assessed renal biopsy findings in LBW children. We examined the relationship between LBW and glomerular density (GD) and/or glomerular volume (GV) in renal biopsy samples as a surrogate for total nephron number. Design, setting, participants, & measurements Renal biopsy findings of children of LBW were compared with those of age-matched control subjects of normal birth weight (NBW) whowere histopathologically diagnosed with FSGS or minimal change nephrotic syndrome (MCNS) from 1995 to 2011. The GD and GV were estimated on the basis of measurements obtained by computerized image analysis. Results A total of 31 subjects (mean age 11 years; eight with low birth weight–FSGS [LBW-FSGS], 10 with normal birth weight–FSGS [NBW-FSGS], and 13 with normal birth weight–minimal change nephrotic syndrome [NBW-MCNS]) were analyzed. The mean birth weight of each group was 777 g (629–1000), 3110 g (2888–3358), and 3120 g (2748–3398), respectively (median [25th–75th percentile]). Age, body mass index, BP, and degrees of globally sclerotic glomeruli at biopsy were comparable between the groups. The GD was lower (LBW-FSGS, 1.4±0.6/mm2; NBW-FSGS, 3.3±1.2/mm2; and NBW-MCNS, 3.6±1.1/mm2 P<0.05) and the GV was greater (LBW-FSGS, 4.1 [3.1–5.1]×106 μm3; NBW-FSGS, 1.6 [1.5–2.1]×106 mm3; and NBW-MCNS, 1.3 [1.1–1.8]×106 μm3 [median, (25th– 75th percentile)]; P,0.05) in patients with LBW-FSGS than in the other patient groups. The GD showed close positive correlations with birth weight (r=0.48) and gestational age (r=0.54), independent of renal function and degree of global glomerular sclerosis. Conclusions A low GD together with marked glomerular enlargement characterizes renal biopsy samples of children born with a LBW at an early stage of gestation.

Original languageEnglish
Pages (from-to)585-590
Number of pages6
JournalClinical Journal of the American Society of Nephrology
Volume12
Issue number4
DOIs
Publication statusPublished - 01-01-2017

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Premature Birth
Low Birth Weight Infant
Proteinuria
Gestational Age
Birth Weight
Kidney
Biopsy
Lipoid Nephrosis
Nephrons
Parturition
Nephrotic Syndrome
Sclerosis
Body Mass Index
Pregnancy

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation

Cite this

Koike, Kentaro ; Ikezumi, Yohei ; Tsuboi, Nobuo ; Kanzaki, Go ; Haruhara, Kotaro ; Okabayashi, Yusuke ; Sasaki, Takaya ; Ogura, Makoto ; Saitoh, Akihiko ; Yokoo, Takashi. / Glomerular density and volume in renal biopsy specimens of children with proteinuria relative to preterm birth and gestational age. In: Clinical Journal of the American Society of Nephrology. 2017 ; Vol. 12, No. 4. pp. 585-590.
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title = "Glomerular density and volume in renal biopsy specimens of children with proteinuria relative to preterm birth and gestational age",
abstract = "Background and objectives A low total nephron number, which is associated with low birth weight (LBW), may indicate increased susceptibility to early-onset renal diseases in children. However, few studies have assessed renal biopsy findings in LBW children. We examined the relationship between LBW and glomerular density (GD) and/or glomerular volume (GV) in renal biopsy samples as a surrogate for total nephron number. Design, setting, participants, & measurements Renal biopsy findings of children of LBW were compared with those of age-matched control subjects of normal birth weight (NBW) whowere histopathologically diagnosed with FSGS or minimal change nephrotic syndrome (MCNS) from 1995 to 2011. The GD and GV were estimated on the basis of measurements obtained by computerized image analysis. Results A total of 31 subjects (mean age 11 years; eight with low birth weight–FSGS [LBW-FSGS], 10 with normal birth weight–FSGS [NBW-FSGS], and 13 with normal birth weight–minimal change nephrotic syndrome [NBW-MCNS]) were analyzed. The mean birth weight of each group was 777 g (629–1000), 3110 g (2888–3358), and 3120 g (2748–3398), respectively (median [25th–75th percentile]). Age, body mass index, BP, and degrees of globally sclerotic glomeruli at biopsy were comparable between the groups. The GD was lower (LBW-FSGS, 1.4±0.6/mm2; NBW-FSGS, 3.3±1.2/mm2; and NBW-MCNS, 3.6±1.1/mm2 P<0.05) and the GV was greater (LBW-FSGS, 4.1 [3.1–5.1]×106 μm3; NBW-FSGS, 1.6 [1.5–2.1]×106 mm3; and NBW-MCNS, 1.3 [1.1–1.8]×106 μm3 [median, (25th– 75th percentile)]; P,0.05) in patients with LBW-FSGS than in the other patient groups. The GD showed close positive correlations with birth weight (r=0.48) and gestational age (r=0.54), independent of renal function and degree of global glomerular sclerosis. Conclusions A low GD together with marked glomerular enlargement characterizes renal biopsy samples of children born with a LBW at an early stage of gestation.",
author = "Kentaro Koike and Yohei Ikezumi and Nobuo Tsuboi and Go Kanzaki and Kotaro Haruhara and Yusuke Okabayashi and Takaya Sasaki and Makoto Ogura and Akihiko Saitoh and Takashi Yokoo",
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Glomerular density and volume in renal biopsy specimens of children with proteinuria relative to preterm birth and gestational age. / Koike, Kentaro; Ikezumi, Yohei; Tsuboi, Nobuo; Kanzaki, Go; Haruhara, Kotaro; Okabayashi, Yusuke; Sasaki, Takaya; Ogura, Makoto; Saitoh, Akihiko; Yokoo, Takashi.

In: Clinical Journal of the American Society of Nephrology, Vol. 12, No. 4, 01.01.2017, p. 585-590.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Glomerular density and volume in renal biopsy specimens of children with proteinuria relative to preterm birth and gestational age

AU - Koike, Kentaro

AU - Ikezumi, Yohei

AU - Tsuboi, Nobuo

AU - Kanzaki, Go

AU - Haruhara, Kotaro

AU - Okabayashi, Yusuke

AU - Sasaki, Takaya

AU - Ogura, Makoto

AU - Saitoh, Akihiko

AU - Yokoo, Takashi

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background and objectives A low total nephron number, which is associated with low birth weight (LBW), may indicate increased susceptibility to early-onset renal diseases in children. However, few studies have assessed renal biopsy findings in LBW children. We examined the relationship between LBW and glomerular density (GD) and/or glomerular volume (GV) in renal biopsy samples as a surrogate for total nephron number. Design, setting, participants, & measurements Renal biopsy findings of children of LBW were compared with those of age-matched control subjects of normal birth weight (NBW) whowere histopathologically diagnosed with FSGS or minimal change nephrotic syndrome (MCNS) from 1995 to 2011. The GD and GV were estimated on the basis of measurements obtained by computerized image analysis. Results A total of 31 subjects (mean age 11 years; eight with low birth weight–FSGS [LBW-FSGS], 10 with normal birth weight–FSGS [NBW-FSGS], and 13 with normal birth weight–minimal change nephrotic syndrome [NBW-MCNS]) were analyzed. The mean birth weight of each group was 777 g (629–1000), 3110 g (2888–3358), and 3120 g (2748–3398), respectively (median [25th–75th percentile]). Age, body mass index, BP, and degrees of globally sclerotic glomeruli at biopsy were comparable between the groups. The GD was lower (LBW-FSGS, 1.4±0.6/mm2; NBW-FSGS, 3.3±1.2/mm2; and NBW-MCNS, 3.6±1.1/mm2 P<0.05) and the GV was greater (LBW-FSGS, 4.1 [3.1–5.1]×106 μm3; NBW-FSGS, 1.6 [1.5–2.1]×106 mm3; and NBW-MCNS, 1.3 [1.1–1.8]×106 μm3 [median, (25th– 75th percentile)]; P,0.05) in patients with LBW-FSGS than in the other patient groups. The GD showed close positive correlations with birth weight (r=0.48) and gestational age (r=0.54), independent of renal function and degree of global glomerular sclerosis. Conclusions A low GD together with marked glomerular enlargement characterizes renal biopsy samples of children born with a LBW at an early stage of gestation.

AB - Background and objectives A low total nephron number, which is associated with low birth weight (LBW), may indicate increased susceptibility to early-onset renal diseases in children. However, few studies have assessed renal biopsy findings in LBW children. We examined the relationship between LBW and glomerular density (GD) and/or glomerular volume (GV) in renal biopsy samples as a surrogate for total nephron number. Design, setting, participants, & measurements Renal biopsy findings of children of LBW were compared with those of age-matched control subjects of normal birth weight (NBW) whowere histopathologically diagnosed with FSGS or minimal change nephrotic syndrome (MCNS) from 1995 to 2011. The GD and GV were estimated on the basis of measurements obtained by computerized image analysis. Results A total of 31 subjects (mean age 11 years; eight with low birth weight–FSGS [LBW-FSGS], 10 with normal birth weight–FSGS [NBW-FSGS], and 13 with normal birth weight–minimal change nephrotic syndrome [NBW-MCNS]) were analyzed. The mean birth weight of each group was 777 g (629–1000), 3110 g (2888–3358), and 3120 g (2748–3398), respectively (median [25th–75th percentile]). Age, body mass index, BP, and degrees of globally sclerotic glomeruli at biopsy were comparable between the groups. The GD was lower (LBW-FSGS, 1.4±0.6/mm2; NBW-FSGS, 3.3±1.2/mm2; and NBW-MCNS, 3.6±1.1/mm2 P<0.05) and the GV was greater (LBW-FSGS, 4.1 [3.1–5.1]×106 μm3; NBW-FSGS, 1.6 [1.5–2.1]×106 mm3; and NBW-MCNS, 1.3 [1.1–1.8]×106 μm3 [median, (25th– 75th percentile)]; P,0.05) in patients with LBW-FSGS than in the other patient groups. The GD showed close positive correlations with birth weight (r=0.48) and gestational age (r=0.54), independent of renal function and degree of global glomerular sclerosis. Conclusions A low GD together with marked glomerular enlargement characterizes renal biopsy samples of children born with a LBW at an early stage of gestation.

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