Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes

Katsumi Iizuka, Jun Takeda, Yukio Horikawa

Research output: Contribution to journalArticlepeer-review

140 Citations (Scopus)

Abstract

Fibroblast growth factor 21 (FGF21) has beneficial effects of improving the plasma glucose and lipid profiles in diabetic rodents. Here, we investigated carbohydrate response element binding protein (ChREBP) involvement in the regulation of FGF21 mRNA expression in liver. Glucose stimulation and adenoviral overexpression of dominant active ChREBP increased FGF21 mRNA. Consistently, adenoviral expression of dominant negative Mlx inhibited glucose induction of FGF21 mRNA. Furthermore, deletion studies of mouse FGF21 gene promoter (-2000 to +65 bp) revealed a glucose responsive region between -74 and -52 bp. These findings suggest that FGF21 expression is regulated by ChREBP.

Original languageEnglish
Pages (from-to)2882-2886
Number of pages5
JournalFEBS Letters
Volume583
Issue number17
DOIs
Publication statusPublished - 03-09-2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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