Glucose intolerance and colorectal cancer risk in a nested case-control study among Japanese people

Kotaro Ozasa, Yoshinori Ito, Koji Suzuki, Yoshiyuki Watanabe, Masayo Kojima, Sadao Zusuki, Shinkan Tokudome, Koji Tamakoshi, Hideaki Toyoshima, Miyuki Kawado, Shuji Hashimoto, Norihiko Hayakawa, Kenji Wakai, Akiko Tamakoshi, Mitsuru Mori, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Harou MikamiYutaka Inaba, Yoshiharu Hoshiyama, Hiroshi Suzuki, Hiroyuki Shimizu, Shogo Kikuchi, Akio Koizumi, Takashi Kawamura, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Takayuki Nose, Takesumi Yoshimura, Akira Shibata, Naoyuki Okamoto, Hideo Shio, Yoshiyuki Ohno, Tomoyuki Kitagawa, Toshio Kukori, Kazuo Tajima

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6 Citations (Scopus)

Abstract

Background: Glucose intolerance may increase the risk of developing colorectal cancer. Methods: In a sero-epidemiological nested case-control study, conducted as part of the Japan Collaborative Cohort Study (JACC Study) for Evaluation of Cancer Risk, we measured serum glycoal-bumin in 123 patients with colorectal cancer and 279 controls. Conditional logistic regression was used to evaluate the risk of colorectal cancer. Results: There were trends towards an association between high levels of glycoalbumin and an increased risk of colorectal cancer in men (odds ratio [OR] = 2.39; 95% confidence interval [Cl]; 0.89-6.36) and between high levels of glycoalbumin and a decreased risk of colorectal cancer in women (OR = 0.41; 95% Cl, 0. 14-1.04). Conclusions: A high level of glycoalbumin may increase the risk of colorectal cancer in men. The finding that high levels of glycoalbumin in women decreased their risk of colorectal cancer was inconsistent with previous reports, and may have been the result of limitations in the procedure in selecting samples and statistical power.

Original languageEnglish
JournalJournal of epidemiology
Volume15
Issue numberSUPPL. 2
DOIs
Publication statusPublished - 14-10-2005

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Glucose Intolerance
Case-Control Studies
Colorectal Neoplasms
Odds Ratio
Japan
Cohort Studies
Logistic Models
Confidence Intervals
glycosylated serum albumin
Serum
Neoplasms

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Ozasa, Kotaro ; Ito, Yoshinori ; Suzuki, Koji ; Watanabe, Yoshiyuki ; Kojima, Masayo ; Zusuki, Sadao ; Tokudome, Shinkan ; Tamakoshi, Koji ; Toyoshima, Hideaki ; Kawado, Miyuki ; Hashimoto, Shuji ; Hayakawa, Norihiko ; Wakai, Kenji ; Tamakoshi, Akiko ; Mori, Mitsuru ; Motohashi, Yutaka ; Tsuji, Ichiro ; Nakamura, Yosikazu ; Iso, Hiroyasu ; Mikami, Harou ; Inaba, Yutaka ; Hoshiyama, Yoshiharu ; Suzuki, Hiroshi ; Shimizu, Hiroyuki ; Kikuchi, Shogo ; Koizumi, Akio ; Kawamura, Takashi ; Miki, Tsuneharu ; Date, Chigusa ; Sakata, Kiyomi ; Nose, Takayuki ; Yoshimura, Takesumi ; Shibata, Akira ; Okamoto, Naoyuki ; Shio, Hideo ; Ohno, Yoshiyuki ; Kitagawa, Tomoyuki ; Kukori, Toshio ; Tajima, Kazuo. / Glucose intolerance and colorectal cancer risk in a nested case-control study among Japanese people. In: Journal of epidemiology. 2005 ; Vol. 15, No. SUPPL. 2.
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title = "Glucose intolerance and colorectal cancer risk in a nested case-control study among Japanese people",
abstract = "Background: Glucose intolerance may increase the risk of developing colorectal cancer. Methods: In a sero-epidemiological nested case-control study, conducted as part of the Japan Collaborative Cohort Study (JACC Study) for Evaluation of Cancer Risk, we measured serum glycoal-bumin in 123 patients with colorectal cancer and 279 controls. Conditional logistic regression was used to evaluate the risk of colorectal cancer. Results: There were trends towards an association between high levels of glycoalbumin and an increased risk of colorectal cancer in men (odds ratio [OR] = 2.39; 95{\%} confidence interval [Cl]; 0.89-6.36) and between high levels of glycoalbumin and a decreased risk of colorectal cancer in women (OR = 0.41; 95{\%} Cl, 0. 14-1.04). Conclusions: A high level of glycoalbumin may increase the risk of colorectal cancer in men. The finding that high levels of glycoalbumin in women decreased their risk of colorectal cancer was inconsistent with previous reports, and may have been the result of limitations in the procedure in selecting samples and statistical power.",
author = "Kotaro Ozasa and Yoshinori Ito and Koji Suzuki and Yoshiyuki Watanabe and Masayo Kojima and Sadao Zusuki and Shinkan Tokudome and Koji Tamakoshi and Hideaki Toyoshima and Miyuki Kawado and Shuji Hashimoto and Norihiko Hayakawa and Kenji Wakai and Akiko Tamakoshi and Mitsuru Mori and Yutaka Motohashi and Ichiro Tsuji and Yosikazu Nakamura and Hiroyasu Iso and Harou Mikami and Yutaka Inaba and Yoshiharu Hoshiyama and Hiroshi Suzuki and Hiroyuki Shimizu and Shogo Kikuchi and Akio Koizumi and Takashi Kawamura and Tsuneharu Miki and Chigusa Date and Kiyomi Sakata and Takayuki Nose and Takesumi Yoshimura and Akira Shibata and Naoyuki Okamoto and Hideo Shio and Yoshiyuki Ohno and Tomoyuki Kitagawa and Toshio Kukori and Kazuo Tajima",
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doi = "10.2188/jea.15.S180",
language = "English",
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journal = "Journal of Epidemiology",
issn = "0917-5040",
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Ozasa, K, Ito, Y, Suzuki, K, Watanabe, Y, Kojima, M, Zusuki, S, Tokudome, S, Tamakoshi, K, Toyoshima, H, Kawado, M, Hashimoto, S, Hayakawa, N, Wakai, K, Tamakoshi, A, Mori, M, Motohashi, Y, Tsuji, I, Nakamura, Y, Iso, H, Mikami, H, Inaba, Y, Hoshiyama, Y, Suzuki, H, Shimizu, H, Kikuchi, S, Koizumi, A, Kawamura, T, Miki, T, Date, C, Sakata, K, Nose, T, Yoshimura, T, Shibata, A, Okamoto, N, Shio, H, Ohno, Y, Kitagawa, T, Kukori, T & Tajima, K 2005, 'Glucose intolerance and colorectal cancer risk in a nested case-control study among Japanese people', Journal of epidemiology, vol. 15, no. SUPPL. 2. https://doi.org/10.2188/jea.15.S180

Glucose intolerance and colorectal cancer risk in a nested case-control study among Japanese people. / Ozasa, Kotaro; Ito, Yoshinori; Suzuki, Koji; Watanabe, Yoshiyuki; Kojima, Masayo; Zusuki, Sadao; Tokudome, Shinkan; Tamakoshi, Koji; Toyoshima, Hideaki; Kawado, Miyuki; Hashimoto, Shuji; Hayakawa, Norihiko; Wakai, Kenji; Tamakoshi, Akiko; Mori, Mitsuru; Motohashi, Yutaka; Tsuji, Ichiro; Nakamura, Yosikazu; Iso, Hiroyasu; Mikami, Harou; Inaba, Yutaka; Hoshiyama, Yoshiharu; Suzuki, Hiroshi; Shimizu, Hiroyuki; Kikuchi, Shogo; Koizumi, Akio; Kawamura, Takashi; Miki, Tsuneharu; Date, Chigusa; Sakata, Kiyomi; Nose, Takayuki; Yoshimura, Takesumi; Shibata, Akira; Okamoto, Naoyuki; Shio, Hideo; Ohno, Yoshiyuki; Kitagawa, Tomoyuki; Kukori, Toshio; Tajima, Kazuo.

In: Journal of epidemiology, Vol. 15, No. SUPPL. 2, 14.10.2005.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Glucose intolerance and colorectal cancer risk in a nested case-control study among Japanese people

AU - Ozasa, Kotaro

AU - Ito, Yoshinori

AU - Suzuki, Koji

AU - Watanabe, Yoshiyuki

AU - Kojima, Masayo

AU - Zusuki, Sadao

AU - Tokudome, Shinkan

AU - Tamakoshi, Koji

AU - Toyoshima, Hideaki

AU - Kawado, Miyuki

AU - Hashimoto, Shuji

AU - Hayakawa, Norihiko

AU - Wakai, Kenji

AU - Tamakoshi, Akiko

AU - Mori, Mitsuru

AU - Motohashi, Yutaka

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Mikami, Harou

AU - Inaba, Yutaka

AU - Hoshiyama, Yoshiharu

AU - Suzuki, Hiroshi

AU - Shimizu, Hiroyuki

AU - Kikuchi, Shogo

AU - Koizumi, Akio

AU - Kawamura, Takashi

AU - Miki, Tsuneharu

AU - Date, Chigusa

AU - Sakata, Kiyomi

AU - Nose, Takayuki

AU - Yoshimura, Takesumi

AU - Shibata, Akira

AU - Okamoto, Naoyuki

AU - Shio, Hideo

AU - Ohno, Yoshiyuki

AU - Kitagawa, Tomoyuki

AU - Kukori, Toshio

AU - Tajima, Kazuo

PY - 2005/10/14

Y1 - 2005/10/14

N2 - Background: Glucose intolerance may increase the risk of developing colorectal cancer. Methods: In a sero-epidemiological nested case-control study, conducted as part of the Japan Collaborative Cohort Study (JACC Study) for Evaluation of Cancer Risk, we measured serum glycoal-bumin in 123 patients with colorectal cancer and 279 controls. Conditional logistic regression was used to evaluate the risk of colorectal cancer. Results: There were trends towards an association between high levels of glycoalbumin and an increased risk of colorectal cancer in men (odds ratio [OR] = 2.39; 95% confidence interval [Cl]; 0.89-6.36) and between high levels of glycoalbumin and a decreased risk of colorectal cancer in women (OR = 0.41; 95% Cl, 0. 14-1.04). Conclusions: A high level of glycoalbumin may increase the risk of colorectal cancer in men. The finding that high levels of glycoalbumin in women decreased their risk of colorectal cancer was inconsistent with previous reports, and may have been the result of limitations in the procedure in selecting samples and statistical power.

AB - Background: Glucose intolerance may increase the risk of developing colorectal cancer. Methods: In a sero-epidemiological nested case-control study, conducted as part of the Japan Collaborative Cohort Study (JACC Study) for Evaluation of Cancer Risk, we measured serum glycoal-bumin in 123 patients with colorectal cancer and 279 controls. Conditional logistic regression was used to evaluate the risk of colorectal cancer. Results: There were trends towards an association between high levels of glycoalbumin and an increased risk of colorectal cancer in men (odds ratio [OR] = 2.39; 95% confidence interval [Cl]; 0.89-6.36) and between high levels of glycoalbumin and a decreased risk of colorectal cancer in women (OR = 0.41; 95% Cl, 0. 14-1.04). Conclusions: A high level of glycoalbumin may increase the risk of colorectal cancer in men. The finding that high levels of glycoalbumin in women decreased their risk of colorectal cancer was inconsistent with previous reports, and may have been the result of limitations in the procedure in selecting samples and statistical power.

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UR - http://www.scopus.com/inward/citedby.url?scp=26244436869&partnerID=8YFLogxK

U2 - 10.2188/jea.15.S180

DO - 10.2188/jea.15.S180

M3 - Article

C2 - 16127231

AN - SCOPUS:26244436869

VL - 15

JO - Journal of Epidemiology

JF - Journal of Epidemiology

SN - 0917-5040

IS - SUPPL. 2

ER -