Glucose intolerance and colorectal cancer risk in a nested case-control study among Japanese people

Kotaro Ozasa, Yoshinori Ito, Koji Suzuki, Yoshiyuki Watanabe, Masayo Kojima, Sadao Zusuki, Shinkan Tokudome, Koji Tamakoshi, Hideaki Toyoshima, Miyuki Kawado, Hashimoto Shuji, Norihiko Hayakawa, Kenji Wakai, Akiko Tamakoshi, Mitsuru Mori, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Harou MikamiYutaka Inaba, Yoshiharu Hoshiyama, Hiroshi Suzuki, Hiroyuki Shimizu, Shogo Kikuchi, Akio Koizumi, Takashi Kawamura, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Takayuki Nose, Takesumi Yoshimura, Akira Shibata, Naoyuki Okamoto, Hideo Shio, Yoshiyuki Ohno, Tomoyuki Kitagawa, Toshio Kukori, Kazuo Tajima

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7 Citations (Scopus)

Abstract

Background: Glucose intolerance may increase the risk of developing colorectal cancer. Methods: In a sero-epidemiological nested case-control study, conducted as part of the Japan Collaborative Cohort Study (JACC Study) for Evaluation of Cancer Risk, we measured serum glycoal-bumin in 123 patients with colorectal cancer and 279 controls. Conditional logistic regression was used to evaluate the risk of colorectal cancer. Results: There were trends towards an association between high levels of glycoalbumin and an increased risk of colorectal cancer in men (odds ratio [OR] = 2.39; 95% confidence interval [Cl]; 0.89-6.36) and between high levels of glycoalbumin and a decreased risk of colorectal cancer in women (OR = 0.41; 95% Cl, 0. 14-1.04). Conclusions: A high level of glycoalbumin may increase the risk of colorectal cancer in men. The finding that high levels of glycoalbumin in women decreased their risk of colorectal cancer was inconsistent with previous reports, and may have been the result of limitations in the procedure in selecting samples and statistical power.

Original languageEnglish
Pages (from-to)S180-S184
JournalJournal of epidemiology
Volume15
Issue numberSUPPL. 2
DOIs
Publication statusPublished - 14-10-2005

All Science Journal Classification (ASJC) codes

  • Epidemiology

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    Ozasa, K., Ito, Y., Suzuki, K., Watanabe, Y., Kojima, M., Zusuki, S., Tokudome, S., Tamakoshi, K., Toyoshima, H., Kawado, M., Shuji, H., Hayakawa, N., Wakai, K., Tamakoshi, A., Mori, M., Motohashi, Y., Tsuji, I., Nakamura, Y., Iso, H., ... Tajima, K. (2005). Glucose intolerance and colorectal cancer risk in a nested case-control study among Japanese people. Journal of epidemiology, 15(SUPPL. 2), S180-S184. https://doi.org/10.2188/jea.15.S180