Glucose transporter 2 concentrations in hyper- and hypothyroid rat livers

T. Mokuno, K. Uchimura, R. Hayashi, N. Hayakawa, M. Makino, M. Nagata, H. Kakizawa, Y. Sawai, M. Kotake, N. Oda, A. Nakai, A. Nagasaka, M. Itoh

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

The deterioration of glucose metabolism frequently observed in hyperthyroidism may be due in part to increased gluconeogenesis in the liver and glucose efflux through hepatocyte plasma membranes. Glucose transporter 2 (GLUT 2), a facilitative glucose transporter localized to the liver and pancreas, may play a role in this distorted glucose metabolism. We examined changes in the levels of GLUT 2 in livers from rats with L-thyroxine-induced hyperthyroidism or methimazole-induced hypothyroidism by using Western blotting to detect GLUT 2. An oral glucose tolerance test revealed an oxyhyperglycemic curve (impaired glucose tolerance) in hyperthyroid rats (n=7) and a flattened curve in hypothyroid rats (n=7), GLUT 2 levels in hepatocyte plasma membranes were significantly increased in hyperthyroid rats and were not decreased in hypothyroid rats compared with euthyroid rats. The same results were obtained with a densitometric assay. These findings suggest that changes in the liver GLUT 2 concentration may contribute to abnormal glucose metabolism in thyroid disorders.

Original languageEnglish
Pages (from-to)285-289
Number of pages5
JournalJournal of Endocrinology
Volume160
Issue number2
DOIs
Publication statusPublished - 1999

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint

Dive into the research topics of 'Glucose transporter 2 concentrations in hyper- and hypothyroid rat livers'. Together they form a unique fingerprint.

Cite this