@article{5dccd50faf1c4bdfac908e505703be98,
title = "Glycometabolic Regulation of the Biogenesis of Small Extracellular Vesicles",
abstract = "Tumor cells secrete various types of small extracellular vesicles, including exosomes and non-exosomal vesicles, each with distinct protein profiles. Through metabolic manipulation in mouse melanoma cells, Harada et al. identify N-glycosylation as a mechanism that selectively regulates non-exosomal vesicle secretion by mediating the sorting of cargo proteins into the vesicles.",
author = "Yoichiro Harada and Kazuki Nakajima and Takehiro Suzuki and Tomoko Fukushige and Kiyotaka Kondo and Junichi Seino and Yuki Ohkawa and Tadashi Suzuki and Hiromasa Inoue and Takuro Kanekura and Naoshi Dohmae and Naoyuki Taniguchi and Ikuro Maruyama",
note = "Funding Information: This work was partly supported by grants to Y.H. from the SENSHIN Medical Research Foundation , the Kodama Memorial Fund for Medical Research , JSPS (KAKENHI grant JP19K06546 ), and the Takeda Science Foundation . We thank our laboratory members for fruitful discussions and Ms. Ayaka Ueda and Mr. Masato Kitano for technical assistance. We also thank Drs. Yusuke Yoshioka, Yurika Sawa, Nobuyoshi Kosaka, and Takahiro Ochiya (Tokyo Medical University) for NTA of the sEVs, as well as members of the Joint Research Laboratory, Kagoshima University Graduate School of Medical and Dental Sciences, for the use of their facilities. Mass spectrometry for lipidomics was performed by the Center for Joint Research Facilities Support at Fujita Health University. We thank Natasha Beeton-Kempen, Ph.D., from Edanz Group ( www.edanzediting.com/ac ) for editing a draft of this manuscript. Funding Information: This work was partly supported by grants to Y.H. from the SENSHIN Medical Research Foundation, the Kodama Memorial Fund for Medical Research, JSPS (KAKENHI grant JP19K06546), and the Takeda Science Foundation. We thank our laboratory members for fruitful discussions and Ms. Ayaka Ueda and Mr. Masato Kitano for technical assistance. We also thank Drs. Yusuke Yoshioka, Yurika Sawa, Nobuyoshi Kosaka, and Takahiro Ochiya (Tokyo Medical University) for NTA of the sEVs, as well as members of the Joint Research Laboratory, Kagoshima University Graduate School of Medical and Dental Sciences, for the use of their facilities. Mass spectrometry for lipidomics was performed by the Center for Joint Research Facilities Support at Fujita Health University. We thank Natasha Beeton-Kempen, Ph.D. from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript. Y.H. designed and conducted the research. Y.H. K.N. Takehiro. Suzuki, T.F. K.K. and J.S. performed the experiments. Y.H. K.N. Y.O. Tadashi Suzuki, H.I. T.K. N.D. N.T. and I.M. analyzed the data. Y.H. wrote the paper. All authors reviewed and approved the final manuscript. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = oct,
day = "13",
doi = "10.1016/j.celrep.2020.108261",
language = "English",
volume = "33",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "2",
}