Glycometabolic Regulation of the Biogenesis of Small Extracellular Vesicles

Yoichiro Harada, Kazuki Nakajima, Takehiro Suzuki, Tomoko Fukushige, Kiyotaka Kondo, Junichi Seino, Yuki Ohkawa, Tadashi Suzuki, Hiromasa Inoue, Takuro Kanekura, Naoshi Dohmae, Naoyuki Taniguchi, Ikuro Maruyama

Research output: Contribution to journalArticlepeer-review

Abstract

Tumor cells secrete various types of small extracellular vesicles, including exosomes and non-exosomal vesicles, each with distinct protein profiles. Through metabolic manipulation in mouse melanoma cells, Harada et al. identify N-glycosylation as a mechanism that selectively regulates non-exosomal vesicle secretion by mediating the sorting of cargo proteins into the vesicles.

Original languageEnglish
Article number108261
JournalCell Reports
Volume33
Issue number2
DOIs
Publication statusPublished - 13-10-2020

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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