Glycometabolic Regulation of the Biogenesis of Small Extracellular Vesicles

Yoichiro Harada; Kazuki Nakajima; Takehiro Suzuki; Tomoko Fukushige; Kiyotaka Kondo; Junichi Seino; Yuki Ohkawa; Tadashi Suzuki; Hiromasa Inoue; Takuro Kanekura; Naoshi Dohmae; Naoyuki Taniguchi; Ikuro Maruyama

doi:10.1016/j.celrep.2020.108261

Glycometabolic Regulation of the Biogenesis of Small Extracellular Vesicles

Yoichiro Harada, Kazuki Nakajima, Takehiro Suzuki, Tomoko Fukushige, Kiyotaka Kondo, Junichi Seino, Yuki Ohkawa, Tadashi Suzuki, Hiromasa Inoue, Takuro Kanekura, Naoshi Dohmae, Naoyuki Taniguchi, Ikuro Maruyama

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Tumor cells secrete various types of small extracellular vesicles, including exosomes and non-exosomal vesicles, each with distinct protein profiles. Through metabolic manipulation in mouse melanoma cells, Harada et al. identify N-glycosylation as a mechanism that selectively regulates non-exosomal vesicle secretion by mediating the sorting of cargo proteins into the vesicles.

Original language	English
Article number	108261
Journal	Cell Reports
Volume	33
Issue number	2
DOIs	https://doi.org/10.1016/j.celrep.2020.108261
Publication status	Published - 13-10-2020

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

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10.1016/j.celrep.2020.108261

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abstract = "Tumor cells secrete various types of small extracellular vesicles, including exosomes and non-exosomal vesicles, each with distinct protein profiles. Through metabolic manipulation in mouse melanoma cells, Harada et al. identify N-glycosylation as a mechanism that selectively regulates non-exosomal vesicle secretion by mediating the sorting of cargo proteins into the vesicles.",

author = "Yoichiro Harada and Kazuki Nakajima and Takehiro Suzuki and Tomoko Fukushige and Kiyotaka Kondo and Junichi Seino and Yuki Ohkawa and Tadashi Suzuki and Hiromasa Inoue and Takuro Kanekura and Naoshi Dohmae and Naoyuki Taniguchi and Ikuro Maruyama",

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AU - Harada, Yoichiro

AU - Nakajima, Kazuki

AU - Suzuki, Takehiro

AU - Fukushige, Tomoko

AU - Kondo, Kiyotaka

AU - Seino, Junichi

AU - Ohkawa, Yuki

AU - Suzuki, Tadashi

AU - Inoue, Hiromasa

AU - Kanekura, Takuro

AU - Dohmae, Naoshi

AU - Taniguchi, Naoyuki

AU - Maruyama, Ikuro

PY - 2020/10/13

Y1 - 2020/10/13

N2 - Tumor cells secrete various types of small extracellular vesicles, including exosomes and non-exosomal vesicles, each with distinct protein profiles. Through metabolic manipulation in mouse melanoma cells, Harada et al. identify N-glycosylation as a mechanism that selectively regulates non-exosomal vesicle secretion by mediating the sorting of cargo proteins into the vesicles.

AB - Tumor cells secrete various types of small extracellular vesicles, including exosomes and non-exosomal vesicles, each with distinct protein profiles. Through metabolic manipulation in mouse melanoma cells, Harada et al. identify N-glycosylation as a mechanism that selectively regulates non-exosomal vesicle secretion by mediating the sorting of cargo proteins into the vesicles.

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Glycometabolic Regulation of the Biogenesis of Small Extracellular Vesicles

Abstract

All Science Journal Classification (ASJC) codes

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