Tumor cells secrete various types of small extracellular vesicles, including exosomes and non-exosomal vesicles, each with distinct protein profiles. Through metabolic manipulation in mouse melanoma cells, Harada et al. identify N-glycosylation as a mechanism that selectively regulates non-exosomal vesicle secretion by mediating the sorting of cargo proteins into the vesicles.
All Science Journal Classification (ASJC) codes
- General Biochemistry,Genetics and Molecular Biology