Glycoproteins gM and gN of pseudorabies virus are dispensable for viral penetration and propagation in the nervous systems of adult mice

Marie Jo Masse, Alice Jöns, J・m Dijkstra, Thomas C. Mettenleiter, Anne Flamand

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Glycoproteins gM and gN are conserved throughout the herpesviruses but are dispensable for viral replication in cell cultures. To assay for a function of these proteins in infection of an animal, deletion mutants of pseudorabies virus lacking gM or gN and corresponding revertants were analyzed for the ability to penetrate and propagate in the nervous systems of adult mice after intranasal inoculation. We demonstrate that neither of the two glycoproteins is required for infection of the nervous systems of mice by pseudorabies virus.

Original languageEnglish
Pages (from-to)10503-10507
Number of pages5
JournalJournal of Virology
Volume73
Issue number12
Publication statusPublished - 01-12-1999

Fingerprint

Suid Herpesvirus 1
Suid herpesvirus 1
nervous system
Nervous System
glycoproteins
Glycoproteins
Neurologic Mutant Mice
Herpesviridae
mice
virus replication
Infection
infection
cell culture
Cell Culture Techniques
mutants
assays
animals
Proteins
proteins

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Masse, Marie Jo ; Jöns, Alice ; Dijkstra, J・m ; Mettenleiter, Thomas C. ; Flamand, Anne. / Glycoproteins gM and gN of pseudorabies virus are dispensable for viral penetration and propagation in the nervous systems of adult mice. In: Journal of Virology. 1999 ; Vol. 73, No. 12. pp. 10503-10507.
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Glycoproteins gM and gN of pseudorabies virus are dispensable for viral penetration and propagation in the nervous systems of adult mice. / Masse, Marie Jo; Jöns, Alice; Dijkstra, J・m; Mettenleiter, Thomas C.; Flamand, Anne.

In: Journal of Virology, Vol. 73, No. 12, 01.12.1999, p. 10503-10507.

Research output: Contribution to journalArticle

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