Granulocyte and monocyte apheresis can control juvenile generalized pustular psoriasis with mutation of IL36RN

Y. Koike, M. Okubo, T. Kiyohara, R. Fukuchi, Y. Sato, S. Kuwatsuka, T. Takeichi, M. Akiyama, Kazumitsu Sugiura, A. Utani

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Patients with deficiency of interleukin-36 receptor antagonist (DITRA), due to mutation of IL36RN, exhibit psoriatic phenotypes, typically generalized pustular psoriasis (GPP). We report a paediatric patient with DITRA, whose cutaneous lesions varied from psoriasis vulgaris in infancy to annular pustular psoriasis with acute exacerbation to GPP at 13 years of age. Conventional systemic treatments for GPP, which include oral retinoids, ciclosporin and methotrexate, are controversial in paediatric cases, because of their adverse effects and uncertain long-term consequences. Granulocyte monocyte apheresis, a process associated with few adverse events, promptly controlled the GPP of our paediatric patient, and has potential as a suitable alternative treatment for paediatric patients with DITRA.

Original languageEnglish
Pages (from-to)1732-1736
Number of pages5
JournalBritish Journal of Dermatology
Volume177
Issue number6
DOIs
Publication statusPublished - 01-01-2017

Fingerprint

Blood Component Removal
Psoriasis
Granulocytes
Monocytes
Interleukin Receptors
Mutation
Pediatrics
Retinoids
Methotrexate
Cyclosporine
Phenotype
Skin
Therapeutics

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Koike, Y., Okubo, M., Kiyohara, T., Fukuchi, R., Sato, Y., Kuwatsuka, S., ... Utani, A. (2017). Granulocyte and monocyte apheresis can control juvenile generalized pustular psoriasis with mutation of IL36RN. British Journal of Dermatology, 177(6), 1732-1736. https://doi.org/10.1111/bjd.15509
Koike, Y. ; Okubo, M. ; Kiyohara, T. ; Fukuchi, R. ; Sato, Y. ; Kuwatsuka, S. ; Takeichi, T. ; Akiyama, M. ; Sugiura, Kazumitsu ; Utani, A. / Granulocyte and monocyte apheresis can control juvenile generalized pustular psoriasis with mutation of IL36RN. In: British Journal of Dermatology. 2017 ; Vol. 177, No. 6. pp. 1732-1736.
@article{e11a04a329684633a7789f56ac5162ad,
title = "Granulocyte and monocyte apheresis can control juvenile generalized pustular psoriasis with mutation of IL36RN",
abstract = "Patients with deficiency of interleukin-36 receptor antagonist (DITRA), due to mutation of IL36RN, exhibit psoriatic phenotypes, typically generalized pustular psoriasis (GPP). We report a paediatric patient with DITRA, whose cutaneous lesions varied from psoriasis vulgaris in infancy to annular pustular psoriasis with acute exacerbation to GPP at 13 years of age. Conventional systemic treatments for GPP, which include oral retinoids, ciclosporin and methotrexate, are controversial in paediatric cases, because of their adverse effects and uncertain long-term consequences. Granulocyte monocyte apheresis, a process associated with few adverse events, promptly controlled the GPP of our paediatric patient, and has potential as a suitable alternative treatment for paediatric patients with DITRA.",
author = "Y. Koike and M. Okubo and T. Kiyohara and R. Fukuchi and Y. Sato and S. Kuwatsuka and T. Takeichi and M. Akiyama and Kazumitsu Sugiura and A. Utani",
year = "2017",
month = "1",
day = "1",
doi = "10.1111/bjd.15509",
language = "English",
volume = "177",
pages = "1732--1736",
journal = "British Journal of Dermatology",
issn = "0007-0963",
publisher = "Wiley-Blackwell",
number = "6",

}

Koike, Y, Okubo, M, Kiyohara, T, Fukuchi, R, Sato, Y, Kuwatsuka, S, Takeichi, T, Akiyama, M, Sugiura, K & Utani, A 2017, 'Granulocyte and monocyte apheresis can control juvenile generalized pustular psoriasis with mutation of IL36RN', British Journal of Dermatology, vol. 177, no. 6, pp. 1732-1736. https://doi.org/10.1111/bjd.15509

Granulocyte and monocyte apheresis can control juvenile generalized pustular psoriasis with mutation of IL36RN. / Koike, Y.; Okubo, M.; Kiyohara, T.; Fukuchi, R.; Sato, Y.; Kuwatsuka, S.; Takeichi, T.; Akiyama, M.; Sugiura, Kazumitsu; Utani, A.

In: British Journal of Dermatology, Vol. 177, No. 6, 01.01.2017, p. 1732-1736.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Granulocyte and monocyte apheresis can control juvenile generalized pustular psoriasis with mutation of IL36RN

AU - Koike, Y.

AU - Okubo, M.

AU - Kiyohara, T.

AU - Fukuchi, R.

AU - Sato, Y.

AU - Kuwatsuka, S.

AU - Takeichi, T.

AU - Akiyama, M.

AU - Sugiura, Kazumitsu

AU - Utani, A.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Patients with deficiency of interleukin-36 receptor antagonist (DITRA), due to mutation of IL36RN, exhibit psoriatic phenotypes, typically generalized pustular psoriasis (GPP). We report a paediatric patient with DITRA, whose cutaneous lesions varied from psoriasis vulgaris in infancy to annular pustular psoriasis with acute exacerbation to GPP at 13 years of age. Conventional systemic treatments for GPP, which include oral retinoids, ciclosporin and methotrexate, are controversial in paediatric cases, because of their adverse effects and uncertain long-term consequences. Granulocyte monocyte apheresis, a process associated with few adverse events, promptly controlled the GPP of our paediatric patient, and has potential as a suitable alternative treatment for paediatric patients with DITRA.

AB - Patients with deficiency of interleukin-36 receptor antagonist (DITRA), due to mutation of IL36RN, exhibit psoriatic phenotypes, typically generalized pustular psoriasis (GPP). We report a paediatric patient with DITRA, whose cutaneous lesions varied from psoriasis vulgaris in infancy to annular pustular psoriasis with acute exacerbation to GPP at 13 years of age. Conventional systemic treatments for GPP, which include oral retinoids, ciclosporin and methotrexate, are controversial in paediatric cases, because of their adverse effects and uncertain long-term consequences. Granulocyte monocyte apheresis, a process associated with few adverse events, promptly controlled the GPP of our paediatric patient, and has potential as a suitable alternative treatment for paediatric patients with DITRA.

UR - http://www.scopus.com/inward/record.url?scp=85030463702&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85030463702&partnerID=8YFLogxK

U2 - 10.1111/bjd.15509

DO - 10.1111/bjd.15509

M3 - Article

C2 - 28369922

AN - SCOPUS:85030463702

VL - 177

SP - 1732

EP - 1736

JO - British Journal of Dermatology

JF - British Journal of Dermatology

SN - 0007-0963

IS - 6

ER -