Granulocyte colony-stimulating factor-producing large cell undifferentiated carcinoma of the lung.

N. Shijubo, Y. Inoue, M. Hirasawa, T. Igarashi, M. Mori, A. Matsuura, T. Uede, A. Suzuki

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We report a case of granulocyte colony-stimulating factor (G-CSF) producing lung cancer. A 38-year-old Japanese woman had a large cell undifferentiated carcinoma of the left lung with severe granulocytosis without any evidence of infection. A specimen was taken from a metastatic cervical lymph node and a tumor cell line was established. The culture supernatant of the line as well as patient's serum exhibited a high level of G-CSF by sandwich enzyme immunoassay. Immunohistochemical analysis demonstrated that tumor cells from transplanted nude mice were stained granularly in the cytoplasma by anti-human G-CSF monoclonal antibody, 4A6.

Original languageEnglish
Pages (from-to)277-280
Number of pages4
JournalInternal medicine (Tokyo, Japan)
Issue number2
Publication statusPublished - 02-1992


All Science Journal Classification (ASJC) codes

  • Internal Medicine

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