Granulocyte colony-stimulating factor-producing large cell undifferentiated carcinoma of the lung.

N. Shijubo, Y. Inoue, M. Hirasawa, T. Igarashi, M. Mori, Akihiro Matsuura, T. Uede, A. Suzuki

Research output: Contribution to journalArticle

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Abstract

We report a case of granulocyte colony-stimulating factor (G-CSF) producing lung cancer. A 38-year-old Japanese woman had a large cell undifferentiated carcinoma of the left lung with severe granulocytosis without any evidence of infection. A specimen was taken from a metastatic cervical lymph node and a tumor cell line was established. The culture supernatant of the line as well as patient's serum exhibited a high level of G-CSF by sandwich enzyme immunoassay. Immunohistochemical analysis demonstrated that tumor cells from transplanted nude mice were stained granularly in the cytoplasma by anti-human G-CSF monoclonal antibody, 4A6.

Original languageEnglish
Pages (from-to)277-280
Number of pages4
JournalInternal medicine (Tokyo, Japan)
Volume31
Issue number2
DOIs
Publication statusPublished - 01-01-1992

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Large Cell Carcinoma
Granulocyte Colony-Stimulating Factor
Carcinoma
Lung
Tumor Cell Line
Immunoenzyme Techniques
Nude Mice
Lung Neoplasms
Lymph Nodes
Monoclonal Antibodies
Infection
Serum
Neoplasms

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Shijubo, N. ; Inoue, Y. ; Hirasawa, M. ; Igarashi, T. ; Mori, M. ; Matsuura, Akihiro ; Uede, T. ; Suzuki, A. / Granulocyte colony-stimulating factor-producing large cell undifferentiated carcinoma of the lung. In: Internal medicine (Tokyo, Japan). 1992 ; Vol. 31, No. 2. pp. 277-280.
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Granulocyte colony-stimulating factor-producing large cell undifferentiated carcinoma of the lung. / Shijubo, N.; Inoue, Y.; Hirasawa, M.; Igarashi, T.; Mori, M.; Matsuura, Akihiro; Uede, T.; Suzuki, A.

In: Internal medicine (Tokyo, Japan), Vol. 31, No. 2, 01.01.1992, p. 277-280.

Research output: Contribution to journalArticle

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