Granulocyte Colony-Stimulating Factor-Producing Large Cell Undifferentiated Carcinoma of the Lung

Noriharu Shijubo; Yuji Inoue; Michio Hirasawa; Tomofumi Igarashi; Masaki Mori; Akihiro Matsuura; Toshimitsu Uede; Akira Suzuki

doi:10.2169/internalmedicine.31.277

Granulocyte Colony-Stimulating Factor-Producing Large Cell Undifferentiated Carcinoma of the Lung

Noriharu Shijubo, Yuji Inoue, Michio Hirasawa, Tomofumi Igarashi, Masaki Mori, Akihiro Matsuura, Toshimitsu Uede, Akira Suzuki

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

We report a case of granulocyte colony-stimulating factor (G-CSF) producing lung cancer. A 38-year-old Japanese woman had a large cell undifferentiated carcinoma of the left lung with severe granulocytosis without any evidence of infection. A specimen was taken from a metastatic cervical lymph node and a tumor cell line was established. The culture supernatant of the line as well as patient's serum exhibited a high level of G-CSF by sandwich enzyme immunoassay. Immunohistochemical analysis demonstrated that tumor cells from transplanted nude mice were stained granularly in the cytoplasma by anti-human G-CSF monoclonal antibody, 4A6.

Original language	English
Pages (from-to)	277-280
Number of pages	4
Journal	Internal Medicine
Volume	31
Issue number	2
DOIs	https://doi.org/10.2169/internalmedicine.31.277
Publication status	Published - 1992
Externally published	Yes

All Science Journal Classification (ASJC) codes

Internal Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.2169/internalmedicine.31.277

Cite this

@article{401b7a8ef4b34d5ca4632a676d939e92,

title = "Granulocyte Colony-Stimulating Factor-Producing Large Cell Undifferentiated Carcinoma of the Lung",

abstract = "We report a case of granulocyte colony-stimulating factor (G-CSF) producing lung cancer. A 38-year-old Japanese woman had a large cell undifferentiated carcinoma of the left lung with severe granulocytosis without any evidence of infection. A specimen was taken from a metastatic cervical lymph node and a tumor cell line was established. The culture supernatant of the line as well as patient's serum exhibited a high level of G-CSF by sandwich enzyme immunoassay. Immunohistochemical analysis demonstrated that tumor cells from transplanted nude mice were stained granularly in the cytoplasma by anti-human G-CSF monoclonal antibody, 4A6.",

author = "Noriharu Shijubo and Yuji Inoue and Michio Hirasawa and Tomofumi Igarashi and Masaki Mori and Akihiro Matsuura and Toshimitsu Uede and Akira Suzuki",

year = "1992",

doi = "10.2169/internalmedicine.31.277",

language = "English",

volume = "31",

pages = "277--280",

journal = "Internal Medicine",

issn = "0918-2918",

publisher = "Japanese Society of Internal Medicine",

number = "2",

}

TY - JOUR

T1 - Granulocyte Colony-Stimulating Factor-Producing Large Cell Undifferentiated Carcinoma of the Lung

AU - Shijubo, Noriharu

AU - Inoue, Yuji

AU - Hirasawa, Michio

AU - Igarashi, Tomofumi

AU - Mori, Masaki

AU - Matsuura, Akihiro

AU - Uede, Toshimitsu

AU - Suzuki, Akira

PY - 1992

Y1 - 1992

N2 - We report a case of granulocyte colony-stimulating factor (G-CSF) producing lung cancer. A 38-year-old Japanese woman had a large cell undifferentiated carcinoma of the left lung with severe granulocytosis without any evidence of infection. A specimen was taken from a metastatic cervical lymph node and a tumor cell line was established. The culture supernatant of the line as well as patient's serum exhibited a high level of G-CSF by sandwich enzyme immunoassay. Immunohistochemical analysis demonstrated that tumor cells from transplanted nude mice were stained granularly in the cytoplasma by anti-human G-CSF monoclonal antibody, 4A6.

AB - We report a case of granulocyte colony-stimulating factor (G-CSF) producing lung cancer. A 38-year-old Japanese woman had a large cell undifferentiated carcinoma of the left lung with severe granulocytosis without any evidence of infection. A specimen was taken from a metastatic cervical lymph node and a tumor cell line was established. The culture supernatant of the line as well as patient's serum exhibited a high level of G-CSF by sandwich enzyme immunoassay. Immunohistochemical analysis demonstrated that tumor cells from transplanted nude mice were stained granularly in the cytoplasma by anti-human G-CSF monoclonal antibody, 4A6.

UR - http://www.scopus.com/inward/record.url?scp=0026815371&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026815371&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.31.277

DO - 10.2169/internalmedicine.31.277

M3 - Article

C2 - 1376180

AN - SCOPUS:0026815371

SN - 0918-2918

VL - 31

SP - 277

EP - 280

JO - Internal Medicine

JF - Internal Medicine

IS - 2

ER -

Granulocyte Colony-Stimulating Factor-Producing Large Cell Undifferentiated Carcinoma of the Lung

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this