Granulocyte Colony-Stimulating Factor-Producing Large Cell Undifferentiated Carcinoma of the Lung

Noriharu Shijubo; Yuji Inoue; Michio Hirasawa; Tomofumi Igarashi; Masaki Mori; Akihiro Matsuura; Toshimitsu Uede; Akira Suzuki

doi:10.2169/internalmedicine.31.277

Granulocyte Colony-Stimulating Factor-Producing Large Cell Undifferentiated Carcinoma of the Lung

Noriharu Shijubo, Yuji Inoue, Michio Hirasawa, Tomofumi Igarashi, Masaki Mori, Akihiro Matsuura, Toshimitsu Uede, Akira Suzuki

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

We report a case of granulocyte colony-stimulating factor (G-CSF) producing lung cancer. A 38-year-old Japanese woman had a large cell undifferentiated carcinoma of the left lung with severe granulocytosis without any evidence of infection. A specimen was taken from a metastatic cervical lymph node and a tumor cell line was established. The culture supernatant of the line as well as patient's serum exhibited a high level of G-CSF by sandwich enzyme immunoassay. Immunohistochemical analysis demonstrated that tumor cells from transplanted nude mice were stained granularly in the cytoplasma by anti-human G-CSF monoclonal antibody, 4A6.

Original language	English
Pages (from-to)	277-280
Number of pages	4
Journal	Internal Medicine
Volume	31
Issue number	2
DOIs	https://doi.org/10.2169/internalmedicine.31.277
Publication status	Published - 1992
Externally published	Yes

All Science Journal Classification (ASJC) codes

Internal Medicine

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10.2169/internalmedicine.31.277

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abstract = "We report a case of granulocyte colony-stimulating factor (G-CSF) producing lung cancer. A 38-year-old Japanese woman had a large cell undifferentiated carcinoma of the left lung with severe granulocytosis without any evidence of infection. A specimen was taken from a metastatic cervical lymph node and a tumor cell line was established. The culture supernatant of the line as well as patient's serum exhibited a high level of G-CSF by sandwich enzyme immunoassay. Immunohistochemical analysis demonstrated that tumor cells from transplanted nude mice were stained granularly in the cytoplasma by anti-human G-CSF monoclonal antibody, 4A6.",

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T1 - Granulocyte Colony-Stimulating Factor-Producing Large Cell Undifferentiated Carcinoma of the Lung

AU - Shijubo, Noriharu

AU - Inoue, Yuji

AU - Hirasawa, Michio

AU - Igarashi, Tomofumi

AU - Mori, Masaki

AU - Matsuura, Akihiro

AU - Uede, Toshimitsu

AU - Suzuki, Akira

PY - 1992

Y1 - 1992

N2 - We report a case of granulocyte colony-stimulating factor (G-CSF) producing lung cancer. A 38-year-old Japanese woman had a large cell undifferentiated carcinoma of the left lung with severe granulocytosis without any evidence of infection. A specimen was taken from a metastatic cervical lymph node and a tumor cell line was established. The culture supernatant of the line as well as patient's serum exhibited a high level of G-CSF by sandwich enzyme immunoassay. Immunohistochemical analysis demonstrated that tumor cells from transplanted nude mice were stained granularly in the cytoplasma by anti-human G-CSF monoclonal antibody, 4A6.

AB - We report a case of granulocyte colony-stimulating factor (G-CSF) producing lung cancer. A 38-year-old Japanese woman had a large cell undifferentiated carcinoma of the left lung with severe granulocytosis without any evidence of infection. A specimen was taken from a metastatic cervical lymph node and a tumor cell line was established. The culture supernatant of the line as well as patient's serum exhibited a high level of G-CSF by sandwich enzyme immunoassay. Immunohistochemical analysis demonstrated that tumor cells from transplanted nude mice were stained granularly in the cytoplasma by anti-human G-CSF monoclonal antibody, 4A6.

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Granulocyte Colony-Stimulating Factor-Producing Large Cell Undifferentiated Carcinoma of the Lung

Abstract

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