Granzyme B-positive primary gastric T-cell lymphoma: Gastric T-cell lymphoma with the possibility of extrathymic T cell origin

T. Murata, S. Nakamura, K. Oka, K. Kawakami, M. Kato, T. Imai, T. Nakayama, M. Kuroda, H. Nakano, M. Watanabe, T. Shiraishi

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11 Citations (Scopus)

Abstract

A case of primary gastric T-cell lymphoma, which was positive for granzyme B, is reported. The patient was a 47-year-old Japanese female who complained of a dull upper abdominal pain. Radiographic and endoscopic examinations revealed an ulcerative infiltrative lesion in her stomach. Following the confirmation of a high-grade malignant lymphoma, a distal gastrectomy with regional lymph nodal dissection was performed. The histology of the gastric lesion revealed a malignant lymphoma of the diffuse pleomorphic type without lymph nodal involvement. Immunohistochemistry revealed that the tumor cells were positive for LCA, CD3, TIA-1 and granzyme B, but were negative for CD4, CD8, CD56, CD30, L-26, EMA, TCR α/β and TCR γ/δ. Because the tumor cells showed T cell nature with cytotoxic activity proved by TIA-1 and granzyme B, and without evidence of further maturation of T cell, a malignant lymphoma originating from extrathymic-derived T cells was suggested.

Original languageEnglish
Pages (from-to)853-857
Number of pages5
JournalPathology International
Volume50
Issue number10
DOIs
Publication statusPublished - 01-01-2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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