Green tea and death from pneumonia in Japan: The Ohsaki cohort study

Ikue Watanabe, Shinichi Kuriyama, Masako Kakizaki, Toshimasa Sone, Kaori Ohmori-Matsuda, Naoki Nakaya, Atsushi Hozawa, Ichiro Tsuji

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Experimental and animal studies have shown the activities of catechins, the main constituents of green tea, against infectious agents. No data are available on the association between green tea consumption and the risk of pneumonia in humans. Objective: We examined the association between green tea consumption and death from pneumonia in humans. Design: We conducted a population-based cohort study, with follow-up from 1995 to 2006. The participants were National Health Insurance beneficiaries in Japan (19,079 men and 21,493 women aged 40-79 y). We excluded participants for whom data on green tea consumption frequency were missing or who had reported a history of cancer, myocardial infarction, stroke, and extreme daily energy intake at baseline. We used Cox proportional hazards regression analysis to calculate hazard ratios (HRs) and their 95% CIs for death from pneumonia according to green tea consumption. Results: Over 12 y of follow-up, we documented 406 deaths from pneumonia. In women, the multivariate HRs of death from pneumonia that were associated with different frequencies of green tea consumption were 1.00 (reference) for <1 cup/d, 0.59 (95% CI: 0.36, 0.98) for 1-2 cups/d, 0.55 (95% CI: 0.33, 0.91) for 3-4 cups/d, and 0.53 (95% CI: 0.33, 0.83) for ≥5 cups/d, respectively (P for trend: 0.008). In men, no significant association was observed. Conclusion: Green tea consumption was associated with a lower risk of death from pneumonia in Japanese women.

Original languageEnglish
Pages (from-to)672-679
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume90
Issue number3
DOIs
Publication statusPublished - 01-09-2009

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Tea
Pneumonia
Japan
Cohort Studies
Catechin
National Health Programs
Insurance Benefits
Energy Intake
Stroke
Myocardial Infarction
Regression Analysis
Population
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Watanabe, I., Kuriyama, S., Kakizaki, M., Sone, T., Ohmori-Matsuda, K., Nakaya, N., ... Tsuji, I. (2009). Green tea and death from pneumonia in Japan: The Ohsaki cohort study. American Journal of Clinical Nutrition, 90(3), 672-679. https://doi.org/10.3945/ajcn.2009.27599
Watanabe, Ikue ; Kuriyama, Shinichi ; Kakizaki, Masako ; Sone, Toshimasa ; Ohmori-Matsuda, Kaori ; Nakaya, Naoki ; Hozawa, Atsushi ; Tsuji, Ichiro. / Green tea and death from pneumonia in Japan : The Ohsaki cohort study. In: American Journal of Clinical Nutrition. 2009 ; Vol. 90, No. 3. pp. 672-679.
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abstract = "Background: Experimental and animal studies have shown the activities of catechins, the main constituents of green tea, against infectious agents. No data are available on the association between green tea consumption and the risk of pneumonia in humans. Objective: We examined the association between green tea consumption and death from pneumonia in humans. Design: We conducted a population-based cohort study, with follow-up from 1995 to 2006. The participants were National Health Insurance beneficiaries in Japan (19,079 men and 21,493 women aged 40-79 y). We excluded participants for whom data on green tea consumption frequency were missing or who had reported a history of cancer, myocardial infarction, stroke, and extreme daily energy intake at baseline. We used Cox proportional hazards regression analysis to calculate hazard ratios (HRs) and their 95{\%} CIs for death from pneumonia according to green tea consumption. Results: Over 12 y of follow-up, we documented 406 deaths from pneumonia. In women, the multivariate HRs of death from pneumonia that were associated with different frequencies of green tea consumption were 1.00 (reference) for <1 cup/d, 0.59 (95{\%} CI: 0.36, 0.98) for 1-2 cups/d, 0.55 (95{\%} CI: 0.33, 0.91) for 3-4 cups/d, and 0.53 (95{\%} CI: 0.33, 0.83) for ≥5 cups/d, respectively (P for trend: 0.008). In men, no significant association was observed. Conclusion: Green tea consumption was associated with a lower risk of death from pneumonia in Japanese women.",
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Watanabe, I, Kuriyama, S, Kakizaki, M, Sone, T, Ohmori-Matsuda, K, Nakaya, N, Hozawa, A & Tsuji, I 2009, 'Green tea and death from pneumonia in Japan: The Ohsaki cohort study', American Journal of Clinical Nutrition, vol. 90, no. 3, pp. 672-679. https://doi.org/10.3945/ajcn.2009.27599

Green tea and death from pneumonia in Japan : The Ohsaki cohort study. / Watanabe, Ikue; Kuriyama, Shinichi; Kakizaki, Masako; Sone, Toshimasa; Ohmori-Matsuda, Kaori; Nakaya, Naoki; Hozawa, Atsushi; Tsuji, Ichiro.

In: American Journal of Clinical Nutrition, Vol. 90, No. 3, 01.09.2009, p. 672-679.

Research output: Contribution to journalArticle

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T1 - Green tea and death from pneumonia in Japan

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AU - Watanabe, Ikue

AU - Kuriyama, Shinichi

AU - Kakizaki, Masako

AU - Sone, Toshimasa

AU - Ohmori-Matsuda, Kaori

AU - Nakaya, Naoki

AU - Hozawa, Atsushi

AU - Tsuji, Ichiro

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N2 - Background: Experimental and animal studies have shown the activities of catechins, the main constituents of green tea, against infectious agents. No data are available on the association between green tea consumption and the risk of pneumonia in humans. Objective: We examined the association between green tea consumption and death from pneumonia in humans. Design: We conducted a population-based cohort study, with follow-up from 1995 to 2006. The participants were National Health Insurance beneficiaries in Japan (19,079 men and 21,493 women aged 40-79 y). We excluded participants for whom data on green tea consumption frequency were missing or who had reported a history of cancer, myocardial infarction, stroke, and extreme daily energy intake at baseline. We used Cox proportional hazards regression analysis to calculate hazard ratios (HRs) and their 95% CIs for death from pneumonia according to green tea consumption. Results: Over 12 y of follow-up, we documented 406 deaths from pneumonia. In women, the multivariate HRs of death from pneumonia that were associated with different frequencies of green tea consumption were 1.00 (reference) for <1 cup/d, 0.59 (95% CI: 0.36, 0.98) for 1-2 cups/d, 0.55 (95% CI: 0.33, 0.91) for 3-4 cups/d, and 0.53 (95% CI: 0.33, 0.83) for ≥5 cups/d, respectively (P for trend: 0.008). In men, no significant association was observed. Conclusion: Green tea consumption was associated with a lower risk of death from pneumonia in Japanese women.

AB - Background: Experimental and animal studies have shown the activities of catechins, the main constituents of green tea, against infectious agents. No data are available on the association between green tea consumption and the risk of pneumonia in humans. Objective: We examined the association between green tea consumption and death from pneumonia in humans. Design: We conducted a population-based cohort study, with follow-up from 1995 to 2006. The participants were National Health Insurance beneficiaries in Japan (19,079 men and 21,493 women aged 40-79 y). We excluded participants for whom data on green tea consumption frequency were missing or who had reported a history of cancer, myocardial infarction, stroke, and extreme daily energy intake at baseline. We used Cox proportional hazards regression analysis to calculate hazard ratios (HRs) and their 95% CIs for death from pneumonia according to green tea consumption. Results: Over 12 y of follow-up, we documented 406 deaths from pneumonia. In women, the multivariate HRs of death from pneumonia that were associated with different frequencies of green tea consumption were 1.00 (reference) for <1 cup/d, 0.59 (95% CI: 0.36, 0.98) for 1-2 cups/d, 0.55 (95% CI: 0.33, 0.91) for 3-4 cups/d, and 0.53 (95% CI: 0.33, 0.83) for ≥5 cups/d, respectively (P for trend: 0.008). In men, no significant association was observed. Conclusion: Green tea consumption was associated with a lower risk of death from pneumonia in Japanese women.

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