Green tea consumption and the risk of liver cancer in Japan: The Ohsaki Cohort study

Akane Ui, Shinichi Kuriyama, Masako Kakizaki, Toshimasa Sone, Naoki Nakaya, Kaori Ohmori-Matsuda, Atsushi Hozawa, Yoshikazu Nishino, Ichiro Tsuji

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Objectives: To investigate the association between green tea consumption and liver cancer incidence. Methods: We prospectively followed 41,761 Japanese adults aged 40-79 years, without a history of cancer at the baseline or any missing data for green tea consumption frequency. Cox proportional hazards models were used to calculate hazard ratios (HR) with 95% confidence intervals (CI), adjusted for age, alcohol drinking, smoking, the consumption of coffee, vegetables, dairy products, fruit, fish, and soybean. Results: Over 9 years of follow-up, among 325,947 accrued person-years, the total incidence of liver cancer was 247 cases. We found that green tea consumption was inversely associated with the incidence of liver cancer. In men, the multivariate-adjusted HRs (95% CIs) for liver cancer incidence with different green tea consumption categories were 1.00 (reference) for <1 cup/day, 0.83 (0.53-1.30) for 1-2 cups/day, 1.11 (0.73-1.68) for 3-4 cups/day, and 0.63 (0.41-0.98) for ≥5 cups/day (p for trend = 0.11). The corresponding data among women were 1.00 (reference), 0.68 (0.35-1.31), 0.79 (0.44-1.44), 0.50 (0.27-0.90) (p for trend = 0.04). Conclusions: Green tea consumption is associated with a reduced risk of liver cancer incidence.

Original languageEnglish
Pages (from-to)1939-1945
Number of pages7
JournalCancer Causes and Control
Volume20
Issue number10
DOIs
Publication statusPublished - 01-12-2009

Fingerprint

Tea
Liver Neoplasms
Japan
Cohort Studies
Incidence
Dairy Products
Coffee
Soybeans
Proportional Hazards Models
Alcohol Drinking
Fruit
Fishes
Smoking
Confidence Intervals
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Ui, Akane ; Kuriyama, Shinichi ; Kakizaki, Masako ; Sone, Toshimasa ; Nakaya, Naoki ; Ohmori-Matsuda, Kaori ; Hozawa, Atsushi ; Nishino, Yoshikazu ; Tsuji, Ichiro. / Green tea consumption and the risk of liver cancer in Japan : The Ohsaki Cohort study. In: Cancer Causes and Control. 2009 ; Vol. 20, No. 10. pp. 1939-1945.
@article{28415259884147148c4ac7e09bee1c1a,
title = "Green tea consumption and the risk of liver cancer in Japan: The Ohsaki Cohort study",
abstract = "Objectives: To investigate the association between green tea consumption and liver cancer incidence. Methods: We prospectively followed 41,761 Japanese adults aged 40-79 years, without a history of cancer at the baseline or any missing data for green tea consumption frequency. Cox proportional hazards models were used to calculate hazard ratios (HR) with 95{\%} confidence intervals (CI), adjusted for age, alcohol drinking, smoking, the consumption of coffee, vegetables, dairy products, fruit, fish, and soybean. Results: Over 9 years of follow-up, among 325,947 accrued person-years, the total incidence of liver cancer was 247 cases. We found that green tea consumption was inversely associated with the incidence of liver cancer. In men, the multivariate-adjusted HRs (95{\%} CIs) for liver cancer incidence with different green tea consumption categories were 1.00 (reference) for <1 cup/day, 0.83 (0.53-1.30) for 1-2 cups/day, 1.11 (0.73-1.68) for 3-4 cups/day, and 0.63 (0.41-0.98) for ≥5 cups/day (p for trend = 0.11). The corresponding data among women were 1.00 (reference), 0.68 (0.35-1.31), 0.79 (0.44-1.44), 0.50 (0.27-0.90) (p for trend = 0.04). Conclusions: Green tea consumption is associated with a reduced risk of liver cancer incidence.",
author = "Akane Ui and Shinichi Kuriyama and Masako Kakizaki and Toshimasa Sone and Naoki Nakaya and Kaori Ohmori-Matsuda and Atsushi Hozawa and Yoshikazu Nishino and Ichiro Tsuji",
year = "2009",
month = "12",
day = "1",
doi = "10.1007/s10552-009-9388-x",
language = "English",
volume = "20",
pages = "1939--1945",
journal = "Cancer Causes and Control",
issn = "0957-5243",
publisher = "Springer Netherlands",
number = "10",

}

Ui, A, Kuriyama, S, Kakizaki, M, Sone, T, Nakaya, N, Ohmori-Matsuda, K, Hozawa, A, Nishino, Y & Tsuji, I 2009, 'Green tea consumption and the risk of liver cancer in Japan: The Ohsaki Cohort study', Cancer Causes and Control, vol. 20, no. 10, pp. 1939-1945. https://doi.org/10.1007/s10552-009-9388-x

Green tea consumption and the risk of liver cancer in Japan : The Ohsaki Cohort study. / Ui, Akane; Kuriyama, Shinichi; Kakizaki, Masako; Sone, Toshimasa; Nakaya, Naoki; Ohmori-Matsuda, Kaori; Hozawa, Atsushi; Nishino, Yoshikazu; Tsuji, Ichiro.

In: Cancer Causes and Control, Vol. 20, No. 10, 01.12.2009, p. 1939-1945.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Green tea consumption and the risk of liver cancer in Japan

T2 - The Ohsaki Cohort study

AU - Ui, Akane

AU - Kuriyama, Shinichi

AU - Kakizaki, Masako

AU - Sone, Toshimasa

AU - Nakaya, Naoki

AU - Ohmori-Matsuda, Kaori

AU - Hozawa, Atsushi

AU - Nishino, Yoshikazu

AU - Tsuji, Ichiro

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Objectives: To investigate the association between green tea consumption and liver cancer incidence. Methods: We prospectively followed 41,761 Japanese adults aged 40-79 years, without a history of cancer at the baseline or any missing data for green tea consumption frequency. Cox proportional hazards models were used to calculate hazard ratios (HR) with 95% confidence intervals (CI), adjusted for age, alcohol drinking, smoking, the consumption of coffee, vegetables, dairy products, fruit, fish, and soybean. Results: Over 9 years of follow-up, among 325,947 accrued person-years, the total incidence of liver cancer was 247 cases. We found that green tea consumption was inversely associated with the incidence of liver cancer. In men, the multivariate-adjusted HRs (95% CIs) for liver cancer incidence with different green tea consumption categories were 1.00 (reference) for <1 cup/day, 0.83 (0.53-1.30) for 1-2 cups/day, 1.11 (0.73-1.68) for 3-4 cups/day, and 0.63 (0.41-0.98) for ≥5 cups/day (p for trend = 0.11). The corresponding data among women were 1.00 (reference), 0.68 (0.35-1.31), 0.79 (0.44-1.44), 0.50 (0.27-0.90) (p for trend = 0.04). Conclusions: Green tea consumption is associated with a reduced risk of liver cancer incidence.

AB - Objectives: To investigate the association between green tea consumption and liver cancer incidence. Methods: We prospectively followed 41,761 Japanese adults aged 40-79 years, without a history of cancer at the baseline or any missing data for green tea consumption frequency. Cox proportional hazards models were used to calculate hazard ratios (HR) with 95% confidence intervals (CI), adjusted for age, alcohol drinking, smoking, the consumption of coffee, vegetables, dairy products, fruit, fish, and soybean. Results: Over 9 years of follow-up, among 325,947 accrued person-years, the total incidence of liver cancer was 247 cases. We found that green tea consumption was inversely associated with the incidence of liver cancer. In men, the multivariate-adjusted HRs (95% CIs) for liver cancer incidence with different green tea consumption categories were 1.00 (reference) for <1 cup/day, 0.83 (0.53-1.30) for 1-2 cups/day, 1.11 (0.73-1.68) for 3-4 cups/day, and 0.63 (0.41-0.98) for ≥5 cups/day (p for trend = 0.11). The corresponding data among women were 1.00 (reference), 0.68 (0.35-1.31), 0.79 (0.44-1.44), 0.50 (0.27-0.90) (p for trend = 0.04). Conclusions: Green tea consumption is associated with a reduced risk of liver cancer incidence.

UR - http://www.scopus.com/inward/record.url?scp=71349088634&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=71349088634&partnerID=8YFLogxK

U2 - 10.1007/s10552-009-9388-x

DO - 10.1007/s10552-009-9388-x

M3 - Article

C2 - 19768563

AN - SCOPUS:71349088634

VL - 20

SP - 1939

EP - 1945

JO - Cancer Causes and Control

JF - Cancer Causes and Control

SN - 0957-5243

IS - 10

ER -