Groped for a novel stimulation method for the prevention of lumbar vertebral compression pressure bone fracture and verification using a bone density drop model mouse

Koji Yamada, Kazuhiro Nishii, Kazuyoshi Sakai, Toshio Teranishi, Mamoru Matsubara

Research output: Contribution to journalArticle

Abstract

Osteoporosis is leaving bones more fragile and susceptible to fracture. It has a massive impact, both physically and mentally, markedly diminishing quality of life. A new form of therapeutic exercise or physical therapy that mitigates the abrupt decrease in bone density in postmenopausal women must quickly be developed to avoid those problems. In this study, ovariectomy (OVX) mice were used as models to simulate the decrease in bone density observed in postmenopausal women. Physical therapy via a shaking stimulus, in the form of moving a platform that rotates in a roughly circular motion in the horizontal plane, was studied as a way to prevent the decrease in bone density of the lumbar vertebrae by analysis of bone histomorphometry, a feat that the stimulus from conventional therapeutic exercise and physical therapy have failed to achieve. Comparison of the stimulus/ovariectomized (+/+) group with the -/+ group indicated significant increases in ES (P < 0.01), N. Mu. Oc (P < 0.05), OV (P < 0.05), O. Th (P < 0.01), and L. Th (P < 0.01) in the +/+ group. If this finding is used clinically, we believe that it could lead to therapy that would prevent compression fractures of the lumbar vertebrae.

Original languageEnglish
Pages (from-to)29-36
Number of pages8
JournalOkajimas Folia Anatomica Japonica
Volume91
Issue number2
DOIs
Publication statusPublished - 01-08-2014

Fingerprint

Bone Fractures
Bone Density
Pressure
Lumbar Vertebrae
Therapeutics
Compression Fractures
Bone and Bones
Exercise Therapy
Ovariectomy
Osteoporosis
Quality of Life
Exercise

All Science Journal Classification (ASJC) codes

  • Anatomy

Cite this

@article{180586ed757b4cd2bb8b907711514e2a,
title = "Groped for a novel stimulation method for the prevention of lumbar vertebral compression pressure bone fracture and verification using a bone density drop model mouse",
abstract = "Osteoporosis is leaving bones more fragile and susceptible to fracture. It has a massive impact, both physically and mentally, markedly diminishing quality of life. A new form of therapeutic exercise or physical therapy that mitigates the abrupt decrease in bone density in postmenopausal women must quickly be developed to avoid those problems. In this study, ovariectomy (OVX) mice were used as models to simulate the decrease in bone density observed in postmenopausal women. Physical therapy via a shaking stimulus, in the form of moving a platform that rotates in a roughly circular motion in the horizontal plane, was studied as a way to prevent the decrease in bone density of the lumbar vertebrae by analysis of bone histomorphometry, a feat that the stimulus from conventional therapeutic exercise and physical therapy have failed to achieve. Comparison of the stimulus/ovariectomized (+/+) group with the -/+ group indicated significant increases in ES (P < 0.01), N. Mu. Oc (P < 0.05), OV (P < 0.05), O. Th (P < 0.01), and L. Th (P < 0.01) in the +/+ group. If this finding is used clinically, we believe that it could lead to therapy that would prevent compression fractures of the lumbar vertebrae.",
author = "Koji Yamada and Kazuhiro Nishii and Kazuyoshi Sakai and Toshio Teranishi and Mamoru Matsubara",
year = "2014",
month = "8",
day = "1",
doi = "10.2535/ofaj.91.29",
language = "English",
volume = "91",
pages = "29--36",
journal = "Okajimas Folia Anatomica Japonica",
issn = "0030-154X",
publisher = "Okajima Foria Anatomica Yaponika Henshubu",
number = "2",

}

Groped for a novel stimulation method for the prevention of lumbar vertebral compression pressure bone fracture and verification using a bone density drop model mouse. / Yamada, Koji; Nishii, Kazuhiro; Sakai, Kazuyoshi; Teranishi, Toshio; Matsubara, Mamoru.

In: Okajimas Folia Anatomica Japonica, Vol. 91, No. 2, 01.08.2014, p. 29-36.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Groped for a novel stimulation method for the prevention of lumbar vertebral compression pressure bone fracture and verification using a bone density drop model mouse

AU - Yamada, Koji

AU - Nishii, Kazuhiro

AU - Sakai, Kazuyoshi

AU - Teranishi, Toshio

AU - Matsubara, Mamoru

PY - 2014/8/1

Y1 - 2014/8/1

N2 - Osteoporosis is leaving bones more fragile and susceptible to fracture. It has a massive impact, both physically and mentally, markedly diminishing quality of life. A new form of therapeutic exercise or physical therapy that mitigates the abrupt decrease in bone density in postmenopausal women must quickly be developed to avoid those problems. In this study, ovariectomy (OVX) mice were used as models to simulate the decrease in bone density observed in postmenopausal women. Physical therapy via a shaking stimulus, in the form of moving a platform that rotates in a roughly circular motion in the horizontal plane, was studied as a way to prevent the decrease in bone density of the lumbar vertebrae by analysis of bone histomorphometry, a feat that the stimulus from conventional therapeutic exercise and physical therapy have failed to achieve. Comparison of the stimulus/ovariectomized (+/+) group with the -/+ group indicated significant increases in ES (P < 0.01), N. Mu. Oc (P < 0.05), OV (P < 0.05), O. Th (P < 0.01), and L. Th (P < 0.01) in the +/+ group. If this finding is used clinically, we believe that it could lead to therapy that would prevent compression fractures of the lumbar vertebrae.

AB - Osteoporosis is leaving bones more fragile and susceptible to fracture. It has a massive impact, both physically and mentally, markedly diminishing quality of life. A new form of therapeutic exercise or physical therapy that mitigates the abrupt decrease in bone density in postmenopausal women must quickly be developed to avoid those problems. In this study, ovariectomy (OVX) mice were used as models to simulate the decrease in bone density observed in postmenopausal women. Physical therapy via a shaking stimulus, in the form of moving a platform that rotates in a roughly circular motion in the horizontal plane, was studied as a way to prevent the decrease in bone density of the lumbar vertebrae by analysis of bone histomorphometry, a feat that the stimulus from conventional therapeutic exercise and physical therapy have failed to achieve. Comparison of the stimulus/ovariectomized (+/+) group with the -/+ group indicated significant increases in ES (P < 0.01), N. Mu. Oc (P < 0.05), OV (P < 0.05), O. Th (P < 0.01), and L. Th (P < 0.01) in the +/+ group. If this finding is used clinically, we believe that it could lead to therapy that would prevent compression fractures of the lumbar vertebrae.

UR - http://www.scopus.com/inward/record.url?scp=84917727224&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84917727224&partnerID=8YFLogxK

U2 - 10.2535/ofaj.91.29

DO - 10.2535/ofaj.91.29

M3 - Article

C2 - 25492842

AN - SCOPUS:84917727224

VL - 91

SP - 29

EP - 36

JO - Okajimas Folia Anatomica Japonica

JF - Okajimas Folia Anatomica Japonica

SN - 0030-154X

IS - 2

ER -