TY - JOUR
T1 - Growth and behavioral traits in donaldson rainbow trout (Oncorhynchus mykiss) cosegregate with classical Major Histocompatibility Complex (MHC) class I genotype
AU - Azuma, Teruo
AU - Dijkstra, Johannes Martinus
AU - Kiryu, Ikunari
AU - Sekiguchi, Takayuki
AU - Terada, Yuichi
AU - Asahina, Kiyoshi
AU - Fischer, Uwe
AU - Ototake, Mitsuru
N1 - Funding Information:
We would like to express our appreciation to Dr. K. Kawasaki, Fisheries Research Agency, for constructing a program used in the locomotor activity experiment. We also would like to thank Dr. James D. Moore, Bodega Marine Laboratory, USA, for his critical reading of the manuscript. This study was supported by ‘‘the promotion of basic research activities for innovative biosciences’’ funded by Bio-oriented Technology Research Advancement Institution (BRAIN), Japan.
PY - 2005/7
Y1 - 2005/7
N2 - Although polymorphism in major histocompatibility complex (MHC) genes has been thought to confer populations with protection against widespread decimation by pathogens, this hypothesis cannot explain the type of large allelic diversity in classical MHC class I (Ia) in rainbow trout. Based on expression of Onmy-UBA (MHC class Ia) in trout neurons, we hypothesized that polymorphism in trout class Ia may contribute to polymorphism in behavioral traits. The present study examined whether polymorphism in Onmy-UBA was associated with behavioral variation in Donaldson rainbow trout (Oncorhynchus mykiss) using experiments on food competition, lure-catch, fright recovery, diel locomotor activity and activity characterized as dominance or aggression. These behavioral traits were investigated in fish having Onmy-UBA*401/*401 or*4901/ *4901 homozygous, or Onmy-UBA*401/*4901 heterozygous genotypes (referred to as BB, FF and BF, respectively). The BB fish exhibited boldness, aggression, faster growth and crepuscular activity, while the FF fish showed little boldness, smaller body size, and diurnal activity with no aggressive behavior. The BF fish displayed traits intermediary to those of the BB and FF fish. These results are consistent with polymorphism in a single MHC class Ia locus driving variation in neural circuits, thereby creating behavioral variation in the trout. This is the first study in any animal to show a potential correlation between polymorphism in MHC class Ia genes with polymorphism of behavioral traits such as aggression.
AB - Although polymorphism in major histocompatibility complex (MHC) genes has been thought to confer populations with protection against widespread decimation by pathogens, this hypothesis cannot explain the type of large allelic diversity in classical MHC class I (Ia) in rainbow trout. Based on expression of Onmy-UBA (MHC class Ia) in trout neurons, we hypothesized that polymorphism in trout class Ia may contribute to polymorphism in behavioral traits. The present study examined whether polymorphism in Onmy-UBA was associated with behavioral variation in Donaldson rainbow trout (Oncorhynchus mykiss) using experiments on food competition, lure-catch, fright recovery, diel locomotor activity and activity characterized as dominance or aggression. These behavioral traits were investigated in fish having Onmy-UBA*401/*401 or*4901/ *4901 homozygous, or Onmy-UBA*401/*4901 heterozygous genotypes (referred to as BB, FF and BF, respectively). The BB fish exhibited boldness, aggression, faster growth and crepuscular activity, while the FF fish showed little boldness, smaller body size, and diurnal activity with no aggressive behavior. The BF fish displayed traits intermediary to those of the BB and FF fish. These results are consistent with polymorphism in a single MHC class Ia locus driving variation in neural circuits, thereby creating behavioral variation in the trout. This is the first study in any animal to show a potential correlation between polymorphism in MHC class Ia genes with polymorphism of behavioral traits such as aggression.
UR - http://www.scopus.com/inward/record.url?scp=20544475911&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20544475911&partnerID=8YFLogxK
U2 - 10.1007/s10519-004-0863-6
DO - 10.1007/s10519-004-0863-6
M3 - Article
C2 - 15971027
AN - SCOPUS:20544475911
SN - 0001-8244
VL - 35
SP - 463
EP - 478
JO - Behavior Genetics
JF - Behavior Genetics
IS - 4
ER -