TY - JOUR
T1 - Growth competition of macrolide-resistant and -susceptible Helicobacter pylori strains
AU - Kanai, Kyoto
AU - Shibayama, Keigo
AU - Suzuki, Satowa
AU - Wachino, Jun Ichi
AU - Arakawa, Yoshichika
PY - 2004
Y1 - 2004
N2 - We examined population dynamics in a mixed culture of clonally related macrolide-resistant and -susceptible Helicobacter pylori strains isolated from a single patient. The resistant strain had a macrolide resistance-conferring A2143G mutation in the 23S rRNA gene. The growth rate of these two strains did not apparently differ when cultured separately. On the other hand, by conducting sequential passage of a mixed culture of the resistant and the susceptible strains, the ratio of the resistant strain to the susceptible strain in the culture typically decreased per passage, indicating that the resistance imposed a significant disadvantage on bacterial fitness in the population.
AB - We examined population dynamics in a mixed culture of clonally related macrolide-resistant and -susceptible Helicobacter pylori strains isolated from a single patient. The resistant strain had a macrolide resistance-conferring A2143G mutation in the 23S rRNA gene. The growth rate of these two strains did not apparently differ when cultured separately. On the other hand, by conducting sequential passage of a mixed culture of the resistant and the susceptible strains, the ratio of the resistant strain to the susceptible strain in the culture typically decreased per passage, indicating that the resistance imposed a significant disadvantage on bacterial fitness in the population.
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U2 - 10.1111/j.1348-0421.2004.tb03628.x
DO - 10.1111/j.1348-0421.2004.tb03628.x
M3 - Article
C2 - 15611615
AN - SCOPUS:11144271957
SN - 0385-5600
VL - 48
SP - 977
EP - 980
JO - MICROBIOLOGY and IMMUNOLOGY
JF - MICROBIOLOGY and IMMUNOLOGY
IS - 12
ER -