Growth hormone releaser attenuates β-amyloid (1-42)-induced memory impairment in mice

Eun Joo Shin, Hyeong Jhoo Jin, Toshitaka Nabeshima, Wang Kee Jhoo, Sang Kwon Myung, Yong Kwang Lim, Seok Chae Jong, Eun Jung Myung, Joo Park Seok, Jin Jang Kyung, Hyoung Chun Kim

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Accumulating evidence indicates that growth hormone (GH) might be effective at preventing the development of Alzheimer's disease. However, exogenous GH treatment has exhibited side effects for clinical application; thus supplementation with amino acids to promote the release of GH could be a possible alternative treatment. In this study, mice that were fed with a diet of GH-releasing supplements had significantly attenuated memory impairments and hippocampal changes in the acetylcholinesterase activity and acetylcholine level induced by amyloid beta protein (Aβ) (1-42). Our results suggest that the use of GH-releasing supplement exerts beneficial effects on the memory impairment induced by Aβ (1-42).

Original languageEnglish
Pages (from-to)117-120
Number of pages4
JournalJournal of Pharmacological Sciences
Issue number1
Publication statusPublished - 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology


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