Growth hormone releaser attenuates β-amyloid (1-42)-induced memory impairment in mice

Eun Joo Shin, Hyeong Jhoo Jin, Toshitaka Nabeshima, Wang Kee Jhoo, Sang Kwon Myung, Yong Kwang Lim, Seok Chae Jong, Eun Jung Myung, Joo Park Seok, Jin Jang Kyung, Hyoung Chun Kim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Accumulating evidence indicates that growth hormone (GH) might be effective at preventing the development of Alzheimer's disease. However, exogenous GH treatment has exhibited side effects for clinical application; thus supplementation with amino acids to promote the release of GH could be a possible alternative treatment. In this study, mice that were fed with a diet of GH-releasing supplements had significantly attenuated memory impairments and hippocampal changes in the acetylcholinesterase activity and acetylcholine level induced by amyloid beta protein (Aβ) (1-42). Our results suggest that the use of GH-releasing supplement exerts beneficial effects on the memory impairment induced by Aβ (1-42).

Original languageEnglish
Pages (from-to)117-120
Number of pages4
JournalJournal of Pharmacological Sciences
Volume99
Issue number1
DOIs
Publication statusPublished - 05-10-2005

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Amyloid
Growth Hormone
Staphylococcal Protein A
Acetylcholinesterase
Acetylcholine
Alzheimer Disease
Diet
Amino Acids

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Cite this

Shin, Eun Joo ; Jin, Hyeong Jhoo ; Nabeshima, Toshitaka ; Jhoo, Wang Kee ; Myung, Sang Kwon ; Lim, Yong Kwang ; Jong, Seok Chae ; Myung, Eun Jung ; Seok, Joo Park ; Kyung, Jin Jang ; Kim, Hyoung Chun. / Growth hormone releaser attenuates β-amyloid (1-42)-induced memory impairment in mice. In: Journal of Pharmacological Sciences. 2005 ; Vol. 99, No. 1. pp. 117-120.
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abstract = "Accumulating evidence indicates that growth hormone (GH) might be effective at preventing the development of Alzheimer's disease. However, exogenous GH treatment has exhibited side effects for clinical application; thus supplementation with amino acids to promote the release of GH could be a possible alternative treatment. In this study, mice that were fed with a diet of GH-releasing supplements had significantly attenuated memory impairments and hippocampal changes in the acetylcholinesterase activity and acetylcholine level induced by amyloid beta protein (Aβ) (1-42). Our results suggest that the use of GH-releasing supplement exerts beneficial effects on the memory impairment induced by Aβ (1-42).",
author = "Shin, {Eun Joo} and Jin, {Hyeong Jhoo} and Toshitaka Nabeshima and Jhoo, {Wang Kee} and Myung, {Sang Kwon} and Lim, {Yong Kwang} and Jong, {Seok Chae} and Myung, {Eun Jung} and Seok, {Joo Park} and Kyung, {Jin Jang} and Kim, {Hyoung Chun}",
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Shin, EJ, Jin, HJ, Nabeshima, T, Jhoo, WK, Myung, SK, Lim, YK, Jong, SC, Myung, EJ, Seok, JP, Kyung, JJ & Kim, HC 2005, 'Growth hormone releaser attenuates β-amyloid (1-42)-induced memory impairment in mice', Journal of Pharmacological Sciences, vol. 99, no. 1, pp. 117-120. https://doi.org/10.1254/jphs.SC0050105

Growth hormone releaser attenuates β-amyloid (1-42)-induced memory impairment in mice. / Shin, Eun Joo; Jin, Hyeong Jhoo; Nabeshima, Toshitaka; Jhoo, Wang Kee; Myung, Sang Kwon; Lim, Yong Kwang; Jong, Seok Chae; Myung, Eun Jung; Seok, Joo Park; Kyung, Jin Jang; Kim, Hyoung Chun.

In: Journal of Pharmacological Sciences, Vol. 99, No. 1, 05.10.2005, p. 117-120.

Research output: Contribution to journalArticle

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AU - Myung, Sang Kwon

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