Growth hormone-releaser diet attenuates β-amyloid(1-42)-induced cognitive impairment via stimulation of the insulin-like growth factor (IGF)-1 receptor in mice

Eun Joo Shin, Jong Seok Chae, Seok Joo Park, Sun Cheol Kim, Kyo Hwan Koo, Kiyofumi Yamada, Toshitaka Nabeshima, Hyoung Chun Kim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We previously demonstrated that the growth hormone (GH)-releaser diet ameliorated β-amyloid (Aβ) (1-42)-induced memory impairment, but the underlying mechanism remained to be characterized. We show here that the GH-releaser diet significantly attenuated Aβ(1-42)-induced impairment in context-dependent conditioned fear, with a reduction in GH levels and changes in hippocampal acetylcholine, acetylcholinesterase, choline acetyltransferase, insulin-like growth factor (IGF)-1, and IGF-1-receptor activity in mice. JB-1, an IGF-1-receptor antagonist, significantly blocked GH-releaser diet-mediated pharmacological actions. Our results suggest that the GH-releaser diet prevents Aβ(1-42)-induced cognitive deficits via stimulation of the hippocampal IGF-1 receptor.

Original languageEnglish
Pages (from-to)139-143
Number of pages5
JournalJournal of Pharmacological Sciences
Volume109
Issue number1
DOIs
Publication statusPublished - 29-01-2009

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Somatomedin Receptors
Amyloid
Growth Hormone
Diet
Choline O-Acetyltransferase
Somatomedins
Acetylcholinesterase
Acetylcholine
Fear
Cognitive Dysfunction
Pharmacology

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Cite this

Shin, Eun Joo ; Chae, Jong Seok ; Park, Seok Joo ; Kim, Sun Cheol ; Koo, Kyo Hwan ; Yamada, Kiyofumi ; Nabeshima, Toshitaka ; Kim, Hyoung Chun. / Growth hormone-releaser diet attenuates β-amyloid(1-42)-induced cognitive impairment via stimulation of the insulin-like growth factor (IGF)-1 receptor in mice. In: Journal of Pharmacological Sciences. 2009 ; Vol. 109, No. 1. pp. 139-143.
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abstract = "We previously demonstrated that the growth hormone (GH)-releaser diet ameliorated β-amyloid (Aβ) (1-42)-induced memory impairment, but the underlying mechanism remained to be characterized. We show here that the GH-releaser diet significantly attenuated Aβ(1-42)-induced impairment in context-dependent conditioned fear, with a reduction in GH levels and changes in hippocampal acetylcholine, acetylcholinesterase, choline acetyltransferase, insulin-like growth factor (IGF)-1, and IGF-1-receptor activity in mice. JB-1, an IGF-1-receptor antagonist, significantly blocked GH-releaser diet-mediated pharmacological actions. Our results suggest that the GH-releaser diet prevents Aβ(1-42)-induced cognitive deficits via stimulation of the hippocampal IGF-1 receptor.",
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Growth hormone-releaser diet attenuates β-amyloid(1-42)-induced cognitive impairment via stimulation of the insulin-like growth factor (IGF)-1 receptor in mice. / Shin, Eun Joo; Chae, Jong Seok; Park, Seok Joo; Kim, Sun Cheol; Koo, Kyo Hwan; Yamada, Kiyofumi; Nabeshima, Toshitaka; Kim, Hyoung Chun.

In: Journal of Pharmacological Sciences, Vol. 109, No. 1, 29.01.2009, p. 139-143.

Research output: Contribution to journalArticle

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