Growth inhibition of stilbenoids in Welwitschiaceae and Gnetaceae through induction of apoptosis in human leukemia HL60 cells

Ibrahim Iliya, Yukihiro Akao, Kenji Matsumoto, Yoshihito Nakagawa, Ali Zulfiqar, Tetsuro Ito, Masayoshi Oyama, Hiroko Murata, Toshiyuki Tanaka, Yoshinori Nozawa, Munekazu Iinuma

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Fifty-six stilbenoids isolated from the families of Welwitschiaceae and Gnetaceae were screened for growth inhibitory activity against HL60 cells, and two compounds (gnemonol G and gnetin I) among them exhibited a strong activity with IC50 of 10.0 μM and 12.2 μM at 48 h incubation, respectively. The growth suppression by gnemonol G and gnetin I was found to be in part due to apoptosis which was assessed by morphological findings such as nuclear condensation and fragmentation, and DNA ladder formation in human leukemia HL60 cells.

Original languageEnglish
Pages (from-to)1490-1492
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume29
Issue number7
DOIs
Publication statusPublished - 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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