Growth inhibition of stilbenoids in Welwitschiaceae and Gnetaceae through induction of apoptosis in human leukemia HL60 cells

Ibrahim Iliya; Yukihiro Akao; Kenji Matsumoto; Yoshihito Nakagawa; Ali Zulfiqar; Tetsuro Ito; Masayoshi Oyama; Hiroko Murata; Toshiyuki Tanaka; Yoshinori Nozawa; Munekazu Iinuma

doi:10.1248/bpb.29.1490

Growth inhibition of stilbenoids in Welwitschiaceae and Gnetaceae through induction of apoptosis in human leukemia HL60 cells

Ibrahim Iliya
, Yukihiro Akao
, Kenji Matsumoto
, Yoshihito Nakagawa
, Ali Zulfiqar
, Tetsuro Ito
, Masayoshi Oyama
, Hiroko Murata
, Toshiyuki Tanaka
, Yoshinori Nozawa
, Munekazu Iinuma

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Fifty-six stilbenoids isolated from the families of Welwitschiaceae and Gnetaceae were screened for growth inhibitory activity against HL60 cells, and two compounds (gnemonol G and gnetin I) among them exhibited a strong activity with IC₅₀ of 10.0 μM and 12.2 μM at 48 h incubation, respectively. The growth suppression by gnemonol G and gnetin I was found to be in part due to apoptosis which was assessed by morphological findings such as nuclear condensation and fragmentation, and DNA ladder formation in human leukemia HL60 cells.

Original language	English
Pages (from-to)	1490-1492
Number of pages	3
Journal	Biological and Pharmaceutical Bulletin
Volume	29
Issue number	7
DOIs	https://doi.org/10.1248/bpb.29.1490
Publication status	Published - 2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmaceutical Science

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10.1248/bpb.29.1490

Cite this

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title = "Growth inhibition of stilbenoids in Welwitschiaceae and Gnetaceae through induction of apoptosis in human leukemia HL60 cells",

abstract = "Fifty-six stilbenoids isolated from the families of Welwitschiaceae and Gnetaceae were screened for growth inhibitory activity against HL60 cells, and two compounds (gnemonol G and gnetin I) among them exhibited a strong activity with IC50 of 10.0 μM and 12.2 μM at 48 h incubation, respectively. The growth suppression by gnemonol G and gnetin I was found to be in part due to apoptosis which was assessed by morphological findings such as nuclear condensation and fragmentation, and DNA ladder formation in human leukemia HL60 cells.",

keywords = "Apoptosis, Gnemonol G, Gnetaceae, Gnetin I, Stilbenoid, Welwitschiaceae",

author = "Ibrahim Iliya and Yukihiro Akao and Kenji Matsumoto and Yoshihito Nakagawa and Ali Zulfiqar and Tetsuro Ito and Masayoshi Oyama and Hiroko Murata and Toshiyuki Tanaka and Yoshinori Nozawa and Munekazu Iinuma",

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doi = "10.1248/bpb.29.1490",

language = "English",

volume = "29",

pages = "1490--1492",

journal = "Biological and Pharmaceutical Bulletin",

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publisher = "Pharmaceutical Society of Japan",

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TY - JOUR

T1 - Growth inhibition of stilbenoids in Welwitschiaceae and Gnetaceae through induction of apoptosis in human leukemia HL60 cells

AU - Iliya, Ibrahim

AU - Akao, Yukihiro

AU - Matsumoto, Kenji

AU - Nakagawa, Yoshihito

AU - Zulfiqar, Ali

AU - Ito, Tetsuro

AU - Oyama, Masayoshi

AU - Murata, Hiroko

AU - Tanaka, Toshiyuki

AU - Nozawa, Yoshinori

AU - Iinuma, Munekazu

PY - 2006

Y1 - 2006

N2 - Fifty-six stilbenoids isolated from the families of Welwitschiaceae and Gnetaceae were screened for growth inhibitory activity against HL60 cells, and two compounds (gnemonol G and gnetin I) among them exhibited a strong activity with IC50 of 10.0 μM and 12.2 μM at 48 h incubation, respectively. The growth suppression by gnemonol G and gnetin I was found to be in part due to apoptosis which was assessed by morphological findings such as nuclear condensation and fragmentation, and DNA ladder formation in human leukemia HL60 cells.

AB - Fifty-six stilbenoids isolated from the families of Welwitschiaceae and Gnetaceae were screened for growth inhibitory activity against HL60 cells, and two compounds (gnemonol G and gnetin I) among them exhibited a strong activity with IC50 of 10.0 μM and 12.2 μM at 48 h incubation, respectively. The growth suppression by gnemonol G and gnetin I was found to be in part due to apoptosis which was assessed by morphological findings such as nuclear condensation and fragmentation, and DNA ladder formation in human leukemia HL60 cells.

KW - Apoptosis

KW - Gnemonol G

KW - Gnetaceae

KW - Gnetin I

KW - Stilbenoid

KW - Welwitschiaceae

UR - https://www.scopus.com/pages/publications/33745685703

UR - https://www.scopus.com/pages/publications/33745685703#tab=citedBy

U2 - 10.1248/bpb.29.1490

DO - 10.1248/bpb.29.1490

M3 - Article

C2 - 16819196

AN - SCOPUS:33745685703

SN - 0918-6158

VL - 29

SP - 1490

EP - 1492

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

IS - 7

ER -

Growth inhibition of stilbenoids in Welwitschiaceae and Gnetaceae through induction of apoptosis in human leukemia HL60 cells

Abstract

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