GTP cyclohydrolase I activity in mononuclear blood cells in juvenile parkinsonism

Hiroshi Ichinose, Tamae Oe, Masayuki Yokochi, Keisuke Fujit, Toshiharu Nagatsu

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

GTP cyclohydrolase I activity in mononuclear blood cells from patients with juvenile parkinsonism (JP) was found to be normal compared to healthy controls. The normal activity in JP contrasts strongly with the decreased activity of 2-20% normal levels in hereditary progressive dystonia with marked diurnal fluctuation (HPD) or dopa responsive dystonia (DRD). The result indicates that the decreased dopamine level in the basal ganglia in JP is not due to decreased activity of GTP cyclohydrolase I, the enzyme for the biosynthesis of the tetrahydrobiopterin cofactor of tyrosine hydroxylase (TH), and the enzyme activity in mononuclear blood cells could be a reliable method for differential diagnosis between JP and HPD/DRD.

Original languageEnglish
Pages (from-to)140-142
Number of pages3
JournalNeuroscience Letters
Volume190
Issue number2
DOIs
Publication statusPublished - 05-05-1995

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GTP Cyclohydrolase
Parkinsonian Disorders
Blood Cells
Tyrosine 3-Monooxygenase
Enzymes
Basal Ganglia
Dopamine
Differential Diagnosis
Dopa-Responsive Dystonia

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Ichinose, Hiroshi ; Oe, Tamae ; Yokochi, Masayuki ; Fujit, Keisuke ; Nagatsu, Toshiharu. / GTP cyclohydrolase I activity in mononuclear blood cells in juvenile parkinsonism. In: Neuroscience Letters. 1995 ; Vol. 190, No. 2. pp. 140-142.
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GTP cyclohydrolase I activity in mononuclear blood cells in juvenile parkinsonism. / Ichinose, Hiroshi; Oe, Tamae; Yokochi, Masayuki; Fujit, Keisuke; Nagatsu, Toshiharu.

In: Neuroscience Letters, Vol. 190, No. 2, 05.05.1995, p. 140-142.

Research output: Contribution to journalArticle

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AU - Fujit, Keisuke

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