Guideline adherence and long-term clinical outcomes in patients with acute myocardial infarction: a Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) substudy

Hideki Wada; Manabu Ogita; Satoru Suwa; Koichi Nakao; Yukio Ozaki; Kazuo Kimura; Junya Ako; Teruo Noguchi; Satoshi Yasuda; Kazuteru Fujimoto; Yasuharu Nakama; Takashi Morita; Wataru Shimizu; Yoshihiko Saito; Atsushi Hirohata; Yasuhiro Morita; Teruo Inoue; Atsunori Okamura; Toshiaki Mano; Kazuhito Hirata; Kengo Tanabe; Yoshisato Shibata; Mafumi Owa; Kenichi Tsujita; Hiroshi Funayama; Nobuaki Kokubu; Ken Kozuma; Shiro Uemura; Tetsuya Toubaru; Keijiro Saku; Shigeru Oshima; Kunihiro Nishimura; Yoshihiro Miyamoto; Hisao Ogawa; Masaharu Ishihara; Tadaya Sato; Hiroyuki Kyono; Tetsuya Tobaru; Takahito Sone; Yasuhiro Sone; Masashi Fujino; Kunihiko Nishimura; Junichi Kotani; Hiroyuki Okura; Masaaki Uematsu; Shirou Uemura; Seiji Hokimoto

doi:10.1177/2048872620902024

Guideline adherence and long-term clinical outcomes in patients with acute myocardial infarction: a Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) substudy

Hideki Wada, Manabu Ogita, Satoru Suwa, Koichi Nakao, Yukio Ozaki, Kazuo Kimura, Junya Ako, Teruo Noguchi, Satoshi Yasuda, Kazuteru Fujimoto, Yasuharu Nakama, Takashi Morita, Wataru Shimizu, Yoshihiko Saito, Atsushi Hirohata, Yasuhiro Morita, Teruo Inoue, Atsunori Okamura, Toshiaki Mano, Kazuhito HirataKengo Tanabe, Yoshisato Shibata, Mafumi Owa, Kenichi Tsujita, Hiroshi Funayama, Nobuaki Kokubu, Ken Kozuma, Shiro Uemura, Tetsuya Toubaru, Keijiro Saku, Shigeru Oshima, Kunihiro Nishimura, Yoshihiro Miyamoto, Hisao Ogawa, Masaharu Ishihara, Tadaya Sato, Hiroyuki Kyono, Tetsuya Tobaru, Takahito Sone, Yasuhiro Sone, Masashi Fujino, Kunihiko Nishimura, Junichi Kotani, Hiroyuki Okura, Masaaki Uematsu, Shirou Uemura, Seiji Hokimoto

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Background: The association between guideline adherence and long-term outcomes in patients with acute myocardial infarction in real-world clinical practice remains unclear. Methods: We investigated 3283 consecutive patients with acute myocardial infarction who were selected from a prospective, nation-wide, multicentre registry (J-MINUET) database covering 28 institutions in Japan between July 2012 and March 2014. Among the 2757 eligible patients, we evaluated the use of seven guideline-recommended therapies, including urgent revascularisation, door-to-balloon time of 90 minutes or less, and five discharge medications (P2Y12 inhibitors on aspirin, beta-blockers, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, statins, lipid-lowering drugs). The primary endpoint was a composite of all-cause death, non-fatal myocardial infarction, non-fatal stroke, cardiac failure and urgent revascularisation for unstable angina up to 3 years. Results: The overall median composite guideline adherence was 85.7%. Patients were divided into the following three groups: complete (100%) adherence group (n=862); moderate adherence (75% to <100%) group (n=911); and low adherence (0–75%) group (n=984). The rate of adverse cardiovascular events was significantly lower in the complete adherence group than in the low and moderate adherence groups (log rank P<0.0001). Multivariate Cox regression analysis showed complete guideline adherence was also significantly associated with lower adverse cardiovascular events compared with low guideline adherence (hazard ratio 0.66; 95% confidence interval 0.52–0.85; P=0.001). Conclusion: The use of guideline-based therapies for patients with acute myocardial infarction in contemporary clinical practice was associated with significant decreases in adverse long-term clinical outcomes. Trial registration: UMIN Unique trial Number: UMIN000010037.

Original language	English
Pages (from-to)	939-947
Number of pages	9
Journal	European Heart Journal: Acute Cardiovascular Care
Volume	9
Issue number	8
DOIs	https://doi.org/10.1177/2048872620902024
Publication status	Published - 12-2020
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Medicine

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10.1177/2048872620902024

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Wada, H., Ogita, M., Suwa, S., Nakao, K., Ozaki, Y., Kimura, K., Ako, J., Noguchi, T., Yasuda, S., Fujimoto, K., Nakama, Y., Morita, T., Shimizu, W., Saito, Y., Hirohata, A., Morita, Y., Inoue, T., Okamura, A., Mano, T., ... Hokimoto, S. (2020). Guideline adherence and long-term clinical outcomes in patients with acute myocardial infarction: a Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) substudy. European Heart Journal: Acute Cardiovascular Care, 9(8), 939-947. https://doi.org/10.1177/2048872620902024

@article{9db20d8f4c9041c49922b7097918d3f2,

title = "Guideline adherence and long-term clinical outcomes in patients with acute myocardial infarction: a Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) substudy",

abstract = "Background: The association between guideline adherence and long-term outcomes in patients with acute myocardial infarction in real-world clinical practice remains unclear. Methods: We investigated 3283 consecutive patients with acute myocardial infarction who were selected from a prospective, nation-wide, multicentre registry (J-MINUET) database covering 28 institutions in Japan between July 2012 and March 2014. Among the 2757 eligible patients, we evaluated the use of seven guideline-recommended therapies, including urgent revascularisation, door-to-balloon time of 90 minutes or less, and five discharge medications (P2Y12 inhibitors on aspirin, beta-blockers, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, statins, lipid-lowering drugs). The primary endpoint was a composite of all-cause death, non-fatal myocardial infarction, non-fatal stroke, cardiac failure and urgent revascularisation for unstable angina up to 3 years. Results: The overall median composite guideline adherence was 85.7%. Patients were divided into the following three groups: complete (100%) adherence group (n=862); moderate adherence (75% to <100%) group (n=911); and low adherence (0–75%) group (n=984). The rate of adverse cardiovascular events was significantly lower in the complete adherence group than in the low and moderate adherence groups (log rank P<0.0001). Multivariate Cox regression analysis showed complete guideline adherence was also significantly associated with lower adverse cardiovascular events compared with low guideline adherence (hazard ratio 0.66; 95% confidence interval 0.52–0.85; P=0.001). Conclusion: The use of guideline-based therapies for patients with acute myocardial infarction in contemporary clinical practice was associated with significant decreases in adverse long-term clinical outcomes. Trial registration: UMIN Unique trial Number: UMIN000010037.",

author = "Hideki Wada and Manabu Ogita and Satoru Suwa and Koichi Nakao and Yukio Ozaki and Kazuo Kimura and Junya Ako and Teruo Noguchi and Satoshi Yasuda and Kazuteru Fujimoto and Yasuharu Nakama and Takashi Morita and Wataru Shimizu and Yoshihiko Saito and Atsushi Hirohata and Yasuhiro Morita and Teruo Inoue and Atsunori Okamura and Toshiaki Mano and Kazuhito Hirata and Kengo Tanabe and Yoshisato Shibata and Mafumi Owa and Kenichi Tsujita and Hiroshi Funayama and Nobuaki Kokubu and Ken Kozuma and Shiro Uemura and Tetsuya Toubaru and Keijiro Saku and Shigeru Oshima and Kunihiro Nishimura and Yoshihiro Miyamoto and Hisao Ogawa and Masaharu Ishihara and Tadaya Sato and Hiroyuki Kyono and Tetsuya Tobaru and Takahito Sone and Yasuhiro Sone and Masashi Fujino and Kunihiko Nishimura and Junichi Kotani and Hiroyuki Okura and Masaaki Uematsu and Shirou Uemura and Seiji Hokimoto",

note = "Publisher Copyright: {\textcopyright} The European Society of Cardiology 2020.",

year = "2020",

month = dec,

doi = "10.1177/2048872620902024",

language = "English",

volume = "9",

pages = "939--947",

journal = "European Heart Journal: Acute Cardiovascular Care",

issn = "2048-8726",

publisher = "Oxford University Press",

number = "8",

}

Wada, H, Ogita, M, Suwa, S, Nakao, K, Ozaki, Y, Kimura, K, Ako, J, Noguchi, T, Yasuda, S, Fujimoto, K, Nakama, Y, Morita, T, Shimizu, W, Saito, Y, Hirohata, A, Morita, Y, Inoue, T, Okamura, A, Mano, T, Hirata, K, Tanabe, K, Shibata, Y, Owa, M, Tsujita, K, Funayama, H, Kokubu, N, Kozuma, K, Uemura, S, Toubaru, T, Saku, K, Oshima, S, Nishimura, K, Miyamoto, Y, Ogawa, H, Ishihara, M, Sato, T, Kyono, H, Tobaru, T, Sone, T, Sone, Y, Fujino, M, Nishimura, K, Kotani, J, Okura, H, Uematsu, M, Uemura, S & Hokimoto, S 2020, 'Guideline adherence and long-term clinical outcomes in patients with acute myocardial infarction: a Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) substudy', European Heart Journal: Acute Cardiovascular Care, vol. 9, no. 8, pp. 939-947. https://doi.org/10.1177/2048872620902024

Guideline adherence and long-term clinical outcomes in patients with acute myocardial infarction: a Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) substudy. / Wada, Hideki; Ogita, Manabu; Suwa, Satoru et al.
In: European Heart Journal: Acute Cardiovascular Care, Vol. 9, No. 8, 12.2020, p. 939-947.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Guideline adherence and long-term clinical outcomes in patients with acute myocardial infarction

T2 - a Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) substudy

AU - Wada, Hideki

AU - Ogita, Manabu

AU - Suwa, Satoru

AU - Nakao, Koichi

AU - Ozaki, Yukio

AU - Kimura, Kazuo

AU - Ako, Junya

AU - Noguchi, Teruo

AU - Yasuda, Satoshi

AU - Fujimoto, Kazuteru

AU - Nakama, Yasuharu

AU - Morita, Takashi

AU - Shimizu, Wataru

AU - Saito, Yoshihiko

AU - Hirohata, Atsushi

AU - Morita, Yasuhiro

AU - Inoue, Teruo

AU - Okamura, Atsunori

AU - Mano, Toshiaki

AU - Hirata, Kazuhito

AU - Tanabe, Kengo

AU - Shibata, Yoshisato

AU - Owa, Mafumi

AU - Tsujita, Kenichi

AU - Funayama, Hiroshi

AU - Kokubu, Nobuaki

AU - Kozuma, Ken

AU - Uemura, Shiro

AU - Toubaru, Tetsuya

AU - Saku, Keijiro

AU - Oshima, Shigeru

AU - Nishimura, Kunihiro

AU - Miyamoto, Yoshihiro

AU - Ogawa, Hisao

AU - Ishihara, Masaharu

AU - Sato, Tadaya

AU - Kyono, Hiroyuki

AU - Tobaru, Tetsuya

AU - Sone, Takahito

AU - Sone, Yasuhiro

AU - Fujino, Masashi

AU - Nishimura, Kunihiko

AU - Kotani, Junichi

AU - Okura, Hiroyuki

AU - Uematsu, Masaaki

AU - Uemura, Shirou

AU - Hokimoto, Seiji

PY - 2020/12

Y1 - 2020/12

N2 - Background: The association between guideline adherence and long-term outcomes in patients with acute myocardial infarction in real-world clinical practice remains unclear. Methods: We investigated 3283 consecutive patients with acute myocardial infarction who were selected from a prospective, nation-wide, multicentre registry (J-MINUET) database covering 28 institutions in Japan between July 2012 and March 2014. Among the 2757 eligible patients, we evaluated the use of seven guideline-recommended therapies, including urgent revascularisation, door-to-balloon time of 90 minutes or less, and five discharge medications (P2Y12 inhibitors on aspirin, beta-blockers, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, statins, lipid-lowering drugs). The primary endpoint was a composite of all-cause death, non-fatal myocardial infarction, non-fatal stroke, cardiac failure and urgent revascularisation for unstable angina up to 3 years. Results: The overall median composite guideline adherence was 85.7%. Patients were divided into the following three groups: complete (100%) adherence group (n=862); moderate adherence (75% to <100%) group (n=911); and low adherence (0–75%) group (n=984). The rate of adverse cardiovascular events was significantly lower in the complete adherence group than in the low and moderate adherence groups (log rank P<0.0001). Multivariate Cox regression analysis showed complete guideline adherence was also significantly associated with lower adverse cardiovascular events compared with low guideline adherence (hazard ratio 0.66; 95% confidence interval 0.52–0.85; P=0.001). Conclusion: The use of guideline-based therapies for patients with acute myocardial infarction in contemporary clinical practice was associated with significant decreases in adverse long-term clinical outcomes. Trial registration: UMIN Unique trial Number: UMIN000010037.

AB - Background: The association between guideline adherence and long-term outcomes in patients with acute myocardial infarction in real-world clinical practice remains unclear. Methods: We investigated 3283 consecutive patients with acute myocardial infarction who were selected from a prospective, nation-wide, multicentre registry (J-MINUET) database covering 28 institutions in Japan between July 2012 and March 2014. Among the 2757 eligible patients, we evaluated the use of seven guideline-recommended therapies, including urgent revascularisation, door-to-balloon time of 90 minutes or less, and five discharge medications (P2Y12 inhibitors on aspirin, beta-blockers, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, statins, lipid-lowering drugs). The primary endpoint was a composite of all-cause death, non-fatal myocardial infarction, non-fatal stroke, cardiac failure and urgent revascularisation for unstable angina up to 3 years. Results: The overall median composite guideline adherence was 85.7%. Patients were divided into the following three groups: complete (100%) adherence group (n=862); moderate adherence (75% to <100%) group (n=911); and low adherence (0–75%) group (n=984). The rate of adverse cardiovascular events was significantly lower in the complete adherence group than in the low and moderate adherence groups (log rank P<0.0001). Multivariate Cox regression analysis showed complete guideline adherence was also significantly associated with lower adverse cardiovascular events compared with low guideline adherence (hazard ratio 0.66; 95% confidence interval 0.52–0.85; P=0.001). Conclusion: The use of guideline-based therapies for patients with acute myocardial infarction in contemporary clinical practice was associated with significant decreases in adverse long-term clinical outcomes. Trial registration: UMIN Unique trial Number: UMIN000010037.

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UR - http://www.scopus.com/inward/citedby.url?scp=85124144776&partnerID=8YFLogxK

U2 - 10.1177/2048872620902024

DO - 10.1177/2048872620902024

M3 - Article

C2 - 31976749

AN - SCOPUS:85124144776

SN - 2048-8726

VL - 9

SP - 939

EP - 947

JO - European Heart Journal: Acute Cardiovascular Care

JF - European Heart Journal: Acute Cardiovascular Care

IS - 8

ER -

Guideline adherence and long-term clinical outcomes in patients with acute myocardial infarction: a Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) substudy

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