Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration

Naohide Kondo, Masahisa Katsuno, Hiroaki Adachi, Makoto Minamiyama, Hideki Doi, Shinjiro Matsumoto, Yu Miyazaki, Madoka Iida, Genki Tohnai, Hideaki Nakatsuji, Shinsuke Ishigaki, Yusuke Fujioka, Hirohisa Watanabe, Fumiaki Tanaka, Akira Nakai, Gen Sobue

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

A crucial feature of adult-onset neurodegenerative diseases is accumulation of abnormal protein in specific brain regions, although the mechanism underlying this pathological selectivity remains unclear. Heat shock factor-1 is a transcriptional regulator of heat shock proteins, molecular chaperones that abrogate neurodegeneration by refolding and solubilizing pathogenic proteins. Here we show that heat shock factor-1 expression levels are associated with the accumulation of pathogenic androgen receptor in spinal and bulbar muscular atrophy, a polyglutamine-induced neurodegenerative disease. In heterozygous heat shock factor-1-knockout spinal and bulbar muscular atrophy mice, abnormal androgen receptor accumulates in the cerebral visual cortex, liver and pituitary, which are not affected in their genetically unmodified counterparts. The depletion of heat shock factor-1 also expands the distribution of pathogenic androgen receptor accumulation in other neuronal regions. Furthermore, lentiviral-mediated delivery of heat shock factor-1 into the brain of spinal and bulbar muscular atrophy mice topically suppresses the pathogenic androgen receptor accumulation and neuronal atrophy. These results suggest that heat shock factor-1 influences the pathological lesion selectivity in spinal and bulbar muscular atrophy.

Original languageEnglish
Article number1405
JournalNature communications
Volume4
DOIs
Publication statusPublished - 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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