Abstract
Epstein-Barr virus (EBV) LMP1 is a major oncoprotein expressed in latent infection. It functions as a TNFR family member and constitutively activates cellular signals, such as NFκB, MAPK, JAK/STAT and AKT. We here screened small molecule inhibitors and isolated HSP90 inhibitors, Radicicol and 17-AAG, as candidates that suppress LMP1 expression and cell proliferation not only in EBV-positive SNK6 Natural Killer (NK) cell lymphoma cells, but also in B and T cells. Tumor formation in immuno-defficient NOD/Shi-scid/IL-2Rγnull (NOG) mice was also retarded. These results suggest that HSP90 inhibitors can be alternative treatments for patients with EBV-positive malignancies.
| Original language | English |
|---|---|
| Article number | e63566 |
| Journal | PloS one |
| Volume | 8 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 03-05-2013 |
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)
- General
Fingerprint Dive into the research topics of 'Heat Shock Protein 90 Inhibitors Repress Latent Membrane Protein 1 (LMP1) Expression and Proliferation of Epstein-Barr Virus-Positive Natural Killer Cell Lymphoma'. Together they form a unique fingerprint.
Cite this
Murata, T., Iwata, S., Siddiquey, M. N. A., Kanazawa, T., Goshima, F., Kawashima, D., Kimura, H., & Tsurumi, T. (2013). Heat Shock Protein 90 Inhibitors Repress Latent Membrane Protein 1 (LMP1) Expression and Proliferation of Epstein-Barr Virus-Positive Natural Killer Cell Lymphoma. PloS one, 8(5), [e63566]. https://doi.org/10.1371/journal.pone.0063566