Height and risk of incident intraparenchymal hemorrhage

Atherosclerosis risk in communities and cardiovascular health study cohorts

Lindsay G. Smith, Hiroshi Yatsuya, Bruce M. Psaty, W. T. Longstreth, Aaron R. Folsom

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Height is inversely associated with incident coronary disease and total stroke, but few studies have examined the association between height and intraparenchymal hemorrhage (IPH). We hypothesized that height would be inversely associated with incident IPH in the combined cohorts of the Atherosclerosis Risk in Communities Study and the Cardiovascular Health Study. Methods: Data on Caucasian and African American participants were used to estimate the association of height at baseline with incident IPH verified by clinician review of medical records and imaging reports. Sex-specific Cox proportional hazards regression models were used to calculate hazard ratios. Results: A total of 20,983 participants initially free of stroke (11,788 women and 9195 men) were followed for an average of 15.9 years (standard deviation [SD] 5.1 years). Incident IPH occurred in 115 women and 73 men. Sex, but not age, race, study, or blood pressure, modified the association (P =.03). After adjustment for risk factors (age, systolic blood pressure, triglycerides, low-density lipoprotein cholesterol, fibrinogen, and race), among women, height was significantly inversely associated with incident IPH (hazard ratio [HR] per SD [6.3 cm] was 0.81; 95% confidence interval [CI] 0.66-0.99; P =.04). The HR for tertile 3 vs 1 in women was 0.63 (95% CI 0.37-1.08). Among men, height was not linearly associated with incident IPH (HR per SD [6.7 cm] was 1.09; 95% CI 0.84-1.40; P = .52). Conclusions: This large prospective study provides evidence that shorter height may be a risk factor for incident IPH in women.

Original languageEnglish
Pages (from-to)323-328
Number of pages6
JournalJournal of Stroke and Cerebrovascular Diseases
Volume22
Issue number4
DOIs
Publication statusPublished - 01-01-2013
Externally publishedYes

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Atherosclerosis
Cohort Studies
Hemorrhage
Health
Confidence Intervals
Blood Pressure
Stroke
Diagnostic Imaging
Proportional Hazards Models
African Americans
LDL Cholesterol
Fibrinogen
Medical Records
Coronary Disease
Triglycerides
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Height and risk of incident intraparenchymal hemorrhage: Atherosclerosis risk in communities and cardiovascular health study cohorts",
abstract = "Background: Height is inversely associated with incident coronary disease and total stroke, but few studies have examined the association between height and intraparenchymal hemorrhage (IPH). We hypothesized that height would be inversely associated with incident IPH in the combined cohorts of the Atherosclerosis Risk in Communities Study and the Cardiovascular Health Study. Methods: Data on Caucasian and African American participants were used to estimate the association of height at baseline with incident IPH verified by clinician review of medical records and imaging reports. Sex-specific Cox proportional hazards regression models were used to calculate hazard ratios. Results: A total of 20,983 participants initially free of stroke (11,788 women and 9195 men) were followed for an average of 15.9 years (standard deviation [SD] 5.1 years). Incident IPH occurred in 115 women and 73 men. Sex, but not age, race, study, or blood pressure, modified the association (P =.03). After adjustment for risk factors (age, systolic blood pressure, triglycerides, low-density lipoprotein cholesterol, fibrinogen, and race), among women, height was significantly inversely associated with incident IPH (hazard ratio [HR] per SD [6.3 cm] was 0.81; 95{\%} confidence interval [CI] 0.66-0.99; P =.04). The HR for tertile 3 vs 1 in women was 0.63 (95{\%} CI 0.37-1.08). Among men, height was not linearly associated with incident IPH (HR per SD [6.7 cm] was 1.09; 95{\%} CI 0.84-1.40; P = .52). Conclusions: This large prospective study provides evidence that shorter height may be a risk factor for incident IPH in women.",
author = "Smith, {Lindsay G.} and Hiroshi Yatsuya and Psaty, {Bruce M.} and Longstreth, {W. T.} and Folsom, {Aaron R.}",
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Height and risk of incident intraparenchymal hemorrhage : Atherosclerosis risk in communities and cardiovascular health study cohorts. / Smith, Lindsay G.; Yatsuya, Hiroshi; Psaty, Bruce M.; Longstreth, W. T.; Folsom, Aaron R.

In: Journal of Stroke and Cerebrovascular Diseases, Vol. 22, No. 4, 01.01.2013, p. 323-328.

Research output: Contribution to journalArticle

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T1 - Height and risk of incident intraparenchymal hemorrhage

T2 - Atherosclerosis risk in communities and cardiovascular health study cohorts

AU - Smith, Lindsay G.

AU - Yatsuya, Hiroshi

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AU - Longstreth, W. T.

AU - Folsom, Aaron R.

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N2 - Background: Height is inversely associated with incident coronary disease and total stroke, but few studies have examined the association between height and intraparenchymal hemorrhage (IPH). We hypothesized that height would be inversely associated with incident IPH in the combined cohorts of the Atherosclerosis Risk in Communities Study and the Cardiovascular Health Study. Methods: Data on Caucasian and African American participants were used to estimate the association of height at baseline with incident IPH verified by clinician review of medical records and imaging reports. Sex-specific Cox proportional hazards regression models were used to calculate hazard ratios. Results: A total of 20,983 participants initially free of stroke (11,788 women and 9195 men) were followed for an average of 15.9 years (standard deviation [SD] 5.1 years). Incident IPH occurred in 115 women and 73 men. Sex, but not age, race, study, or blood pressure, modified the association (P =.03). After adjustment for risk factors (age, systolic blood pressure, triglycerides, low-density lipoprotein cholesterol, fibrinogen, and race), among women, height was significantly inversely associated with incident IPH (hazard ratio [HR] per SD [6.3 cm] was 0.81; 95% confidence interval [CI] 0.66-0.99; P =.04). The HR for tertile 3 vs 1 in women was 0.63 (95% CI 0.37-1.08). Among men, height was not linearly associated with incident IPH (HR per SD [6.7 cm] was 1.09; 95% CI 0.84-1.40; P = .52). Conclusions: This large prospective study provides evidence that shorter height may be a risk factor for incident IPH in women.

AB - Background: Height is inversely associated with incident coronary disease and total stroke, but few studies have examined the association between height and intraparenchymal hemorrhage (IPH). We hypothesized that height would be inversely associated with incident IPH in the combined cohorts of the Atherosclerosis Risk in Communities Study and the Cardiovascular Health Study. Methods: Data on Caucasian and African American participants were used to estimate the association of height at baseline with incident IPH verified by clinician review of medical records and imaging reports. Sex-specific Cox proportional hazards regression models were used to calculate hazard ratios. Results: A total of 20,983 participants initially free of stroke (11,788 women and 9195 men) were followed for an average of 15.9 years (standard deviation [SD] 5.1 years). Incident IPH occurred in 115 women and 73 men. Sex, but not age, race, study, or blood pressure, modified the association (P =.03). After adjustment for risk factors (age, systolic blood pressure, triglycerides, low-density lipoprotein cholesterol, fibrinogen, and race), among women, height was significantly inversely associated with incident IPH (hazard ratio [HR] per SD [6.3 cm] was 0.81; 95% confidence interval [CI] 0.66-0.99; P =.04). The HR for tertile 3 vs 1 in women was 0.63 (95% CI 0.37-1.08). Among men, height was not linearly associated with incident IPH (HR per SD [6.7 cm] was 1.09; 95% CI 0.84-1.40; P = .52). Conclusions: This large prospective study provides evidence that shorter height may be a risk factor for incident IPH in women.

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