Helicobacter pylori infection and gastric carcinogenesis in rodent models

Tetsuya Tsukamoto, Takeshi Toyoda, Tsutomu Mizoshita, Masae Tatematsu

Research output: Contribution to journalReview articlepeer-review

23 Citations (Scopus)


Helicobacter pylori infection is an important factor for gastric carcinogenesis in human. In carcinogen-treated Mongolian gerbils, H. pylori infection enhances stomach carcinogenesis, while infection alone induced severe hyperplasia called heterotopic proliferative glands. A high-salt diet or early acquisition of the bacteria exacerbates inflammation and carcinogenesis. Oxygen radical scavengers or anti-inflammatory chemicals as well as eradication of H. pylori are effective to prevent carcinogenesis. H. pylori-associated inflammation induces intestinal metaplasia and intestinalization of stomach cancers independently. It is necessary to control cancer development not only in H. pylori-positive cases but also in H. pylori-negative metaplastic gastritis.

Original languageEnglish
Pages (from-to)177-190
Number of pages14
JournalSeminars in Immunopathology
Issue number2
Publication statusPublished - 03-2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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