Hematopoietic tissues, as a playground of receptor tyrosine kinases of the PDGF-receptor family

Hisahiro Yoshida, Nobuyuki Takakura, Masanori Hirashima, Hiroshi Kataoka, Kunihiro Tsuchida, Satomi Nishikawa, Shin Ichi Nishikawa

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Three receptor tyrosine kinases of the PDGF receptor family (RTKP) that clustered within 1000 Kb of the mouse chromosome 5 constitute an interesting unit that are expressed in three distinct cell lineages essential for constructing hematopoietic tissues. Namely, the c-kit gene that is expressed in hematopoietic stem cells is flanked by pdgfrα and flk genes expressed respectively in stromal cells and vascular endothelial cells. In this article, we review our results on their expression in the embryonic hematopoietic tissues. We found that co-expression of Flk1 and c-Kit was frequently detected either in vascular endothelial cells or hematopoietic cells in the early hematopoietic tissues. On the other hand, the three RTKPs are expressed in different cell lineages in the fetal liver. On the basis of this finding, we propose two modes of embryonic hematopoiesis; hematogenic angiopoiesis and hematopoiesis.

Original languageEnglish
Pages (from-to)321-332
Number of pages12
JournalDevelopmental and Comparative Immunology
Volume22
Issue number3
DOIs
Publication statusPublished - 01-05-1998

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Platelet-Derived Growth Factor Receptors
Receptor Protein-Tyrosine Kinases
Hematopoiesis
Cell Lineage
Endothelial Cells
Chromosomes, Human, Pair 5
Stromal Cells
Hematopoietic Stem Cells
Genes
Liver

All Science Journal Classification (ASJC) codes

  • Immunology
  • Developmental Biology

Cite this

Yoshida, Hisahiro ; Takakura, Nobuyuki ; Hirashima, Masanori ; Kataoka, Hiroshi ; Tsuchida, Kunihiro ; Nishikawa, Satomi ; Nishikawa, Shin Ichi. / Hematopoietic tissues, as a playground of receptor tyrosine kinases of the PDGF-receptor family. In: Developmental and Comparative Immunology. 1998 ; Vol. 22, No. 3. pp. 321-332.
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Hematopoietic tissues, as a playground of receptor tyrosine kinases of the PDGF-receptor family. / Yoshida, Hisahiro; Takakura, Nobuyuki; Hirashima, Masanori; Kataoka, Hiroshi; Tsuchida, Kunihiro; Nishikawa, Satomi; Nishikawa, Shin Ichi.

In: Developmental and Comparative Immunology, Vol. 22, No. 3, 01.05.1998, p. 321-332.

Research output: Contribution to journalArticle

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