Hemodynamic-based mapping of neural activity in medetomidine-sedated rats using a 1.5T compact magnetic resonance imaging system: A preliminary study

Masayuki Yamada, Kazuki Takano, Yuki Kawai, Ryoichi Kato

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The use of compact magnetic resonance (MR) systems for the neuroimaging of small animals is spreading. We investigated the potential of such systems in functional MR imaging (fMRI) of somatosensory cortex activity elicited by forepaw stimulation in medetomidine-sedated rats. Using a 1.5-tesla compact imager, we detected maximum activity with an electrophysiologically optimized frequency of 9Hz in 3 appropriately sedated rats. With this compact system, we successfully mapped neural activity by combining optimum stimulation for a large hemodynamic response with appropriate anesthesia, thus demonstrating the utility of such systems in hemodynamic-based fMRI in preclinical and translational research.

Original languageEnglish
Pages (from-to)243-250
Number of pages8
JournalMagnetic Resonance in Medical Sciences
Volume14
Issue number3
DOIs
Publication statusPublished - 01-01-2015

Fingerprint

Medetomidine
Hemodynamics
Magnetic Resonance Imaging
Somatosensory Cortex
Translational Medical Research
Neuroimaging
Magnetic Resonance Spectroscopy
Anesthesia

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

@article{de88a9454b5748c3aa9077379d6d31b0,
title = "Hemodynamic-based mapping of neural activity in medetomidine-sedated rats using a 1.5T compact magnetic resonance imaging system: A preliminary study",
abstract = "The use of compact magnetic resonance (MR) systems for the neuroimaging of small animals is spreading. We investigated the potential of such systems in functional MR imaging (fMRI) of somatosensory cortex activity elicited by forepaw stimulation in medetomidine-sedated rats. Using a 1.5-tesla compact imager, we detected maximum activity with an electrophysiologically optimized frequency of 9Hz in 3 appropriately sedated rats. With this compact system, we successfully mapped neural activity by combining optimum stimulation for a large hemodynamic response with appropriate anesthesia, thus demonstrating the utility of such systems in hemodynamic-based fMRI in preclinical and translational research.",
author = "Masayuki Yamada and Kazuki Takano and Yuki Kawai and Ryoichi Kato",
year = "2015",
month = "1",
day = "1",
doi = "10.2463/mrms.2014-0084",
language = "English",
volume = "14",
pages = "243--250",
journal = "Magnetic Resonance in Medical Sciences",
issn = "1347-3182",
publisher = "Japan Society of Magnetic Resonance in Medicine",
number = "3",

}

Hemodynamic-based mapping of neural activity in medetomidine-sedated rats using a 1.5T compact magnetic resonance imaging system : A preliminary study. / Yamada, Masayuki; Takano, Kazuki; Kawai, Yuki; Kato, Ryoichi.

In: Magnetic Resonance in Medical Sciences, Vol. 14, No. 3, 01.01.2015, p. 243-250.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hemodynamic-based mapping of neural activity in medetomidine-sedated rats using a 1.5T compact magnetic resonance imaging system

T2 - A preliminary study

AU - Yamada, Masayuki

AU - Takano, Kazuki

AU - Kawai, Yuki

AU - Kato, Ryoichi

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The use of compact magnetic resonance (MR) systems for the neuroimaging of small animals is spreading. We investigated the potential of such systems in functional MR imaging (fMRI) of somatosensory cortex activity elicited by forepaw stimulation in medetomidine-sedated rats. Using a 1.5-tesla compact imager, we detected maximum activity with an electrophysiologically optimized frequency of 9Hz in 3 appropriately sedated rats. With this compact system, we successfully mapped neural activity by combining optimum stimulation for a large hemodynamic response with appropriate anesthesia, thus demonstrating the utility of such systems in hemodynamic-based fMRI in preclinical and translational research.

AB - The use of compact magnetic resonance (MR) systems for the neuroimaging of small animals is spreading. We investigated the potential of such systems in functional MR imaging (fMRI) of somatosensory cortex activity elicited by forepaw stimulation in medetomidine-sedated rats. Using a 1.5-tesla compact imager, we detected maximum activity with an electrophysiologically optimized frequency of 9Hz in 3 appropriately sedated rats. With this compact system, we successfully mapped neural activity by combining optimum stimulation for a large hemodynamic response with appropriate anesthesia, thus demonstrating the utility of such systems in hemodynamic-based fMRI in preclinical and translational research.

UR - http://www.scopus.com/inward/record.url?scp=84939148821&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939148821&partnerID=8YFLogxK

U2 - 10.2463/mrms.2014-0084

DO - 10.2463/mrms.2014-0084

M3 - Article

C2 - 25833273

AN - SCOPUS:84939148821

VL - 14

SP - 243

EP - 250

JO - Magnetic Resonance in Medical Sciences

JF - Magnetic Resonance in Medical Sciences

SN - 1347-3182

IS - 3

ER -