TY - JOUR
T1 - Hemodynamic-based mapping of neural activity in medetomidine-sedated rats using a 1.5T compact magnetic resonance imaging system
T2 - A preliminary study
AU - Yamada, Masayuki
AU - Takano, Kazuki
AU - Kawai, Yuki
AU - Kato, Ryoichi
N1 - Publisher Copyright:
© 2015 Japanese Society for Magnetic Resonance in Medicine.
PY - 2015/8/11
Y1 - 2015/8/11
N2 - The use of compact magnetic resonance (MR) systems for the neuroimaging of small animals is spreading. We investigated the potential of such systems in functional MR imaging (fMRI) of somatosensory cortex activity elicited by forepaw stimulation in medetomidine-sedated rats. Using a 1.5-tesla compact imager, we detected maximum activity with an electrophysiologically optimized frequency of 9Hz in 3 appropriately sedated rats. With this compact system, we successfully mapped neural activity by combining optimum stimulation for a large hemodynamic response with appropriate anesthesia, thus demonstrating the utility of such systems in hemodynamic-based fMRI in preclinical and translational research.
AB - The use of compact magnetic resonance (MR) systems for the neuroimaging of small animals is spreading. We investigated the potential of such systems in functional MR imaging (fMRI) of somatosensory cortex activity elicited by forepaw stimulation in medetomidine-sedated rats. Using a 1.5-tesla compact imager, we detected maximum activity with an electrophysiologically optimized frequency of 9Hz in 3 appropriately sedated rats. With this compact system, we successfully mapped neural activity by combining optimum stimulation for a large hemodynamic response with appropriate anesthesia, thus demonstrating the utility of such systems in hemodynamic-based fMRI in preclinical and translational research.
UR - http://www.scopus.com/inward/record.url?scp=84939148821&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84939148821&partnerID=8YFLogxK
U2 - 10.2463/mrms.2014-0084
DO - 10.2463/mrms.2014-0084
M3 - Article
C2 - 25833273
AN - SCOPUS:84939148821
SN - 1347-3182
VL - 14
SP - 243
EP - 250
JO - Magnetic Resonance in Medical Sciences
JF - Magnetic Resonance in Medical Sciences
IS - 3
ER -