Hemodynamic investigation of the effectiveness of a two overlapping flow diverter configuration for cerebral aneurysm treatment

Yuya Uchiyama, Soichiro Fujimura, Hiroyuki Takao, Takashi Suzuki, Motoharu Hayakawa, Toshihiro Ishibashi, Kostadin Karagiozov, Koji Fukudome, Yuichi Murayama, Makoto Yamamoto

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Flow diverters (FDs) are widely employed as endovascular treatment devices for large or wide-neck cerebral aneurysms. Occasionally, overlapped FDs are deployed to enhance the flow diversion effect. In this study, we investigated the hemodynamics of overlapping FDs via computational fluid dynamics (CFD) simulations. We reproduced the arterial geometry of a patient who had experienced the deployment of two overlapping FDs. We utilized two stent patterns, namely the patterns for one FD and two overlapping FDs. We calculated the velocity, mass flow rate, wall shear stress, and pressure loss coefficient as well as their change rates for each pattern relative to the no-FD pattern results. The CFD simulation results indicated that the characteristics of the blood flow inside the aneurysm were minimally affected by the deployment of a single FD; in contrast, the overlapping FD pattern results revealed significant changes in the flow. Further, the velocity at an inspection plane within the aneurysm sac decreased by up to 92.2% and 31.0% in the cases of the overlapping and single FD patterns, respectively, relative to the no-FD pattern. The simulations successfully reproduced the hemodynamics, and the qualitative and quantitative investigations are meaningful with regard to the clinical outcomes of overlapped FD deployment.

Original languageEnglish
Article number143
JournalBioengineering
Volume8
Issue number10
DOIs
Publication statusPublished - 10-2021

All Science Journal Classification (ASJC) codes

  • Bioengineering

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