Hemophagocytic lymphohistiocytosis in a fatal case of severe fever with thrombocytopenia syndrome

Ayako Nakano, Hirohisa Ogawa, Yoshinori Nakanishi, Hiromi Fujita, Fumihiko Mahara, Kazuya Shiogama, Yutaka Tsutsumi, Toshiaki Takeichi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging disease caused by a novel Bunyavirus with a high mortality rate. We herein report a fatal case of an 86-year-old woman with SFTS complaining of a fever, fatigue, and bicytopenia. Her condition deteriorated with rapid progression of bleeding tendency, disturbance of consciousness, and multiple organ failure leading to death on Day 6 of her illness. The histopathological findings in the autopsy revealed marked infiltration of macrophages with hemophagocytosis in the bone marrow, liver, and spleen leading to a diagnosis of hemophagocytic lymphohistiocytosis (HLH). HLH might be a critical pathogenesis in fatal cases of SFTS.

Original languageEnglish
Pages (from-to)1597-1602
Number of pages6
JournalInternal Medicine
Volume56
Issue number12
DOIs
Publication statusPublished - 01-01-2017

Fingerprint

Hemophagocytic Lymphohistiocytosis
Thrombocytopenia
Fever
Orthobunyavirus
Sick Leave
Multiple Organ Failure
Consciousness
Fatigue
Autopsy
Spleen
Bone Marrow
Macrophages
Hemorrhage
Mortality
Liver

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Nakano, Ayako ; Ogawa, Hirohisa ; Nakanishi, Yoshinori ; Fujita, Hiromi ; Mahara, Fumihiko ; Shiogama, Kazuya ; Tsutsumi, Yutaka ; Takeichi, Toshiaki. / Hemophagocytic lymphohistiocytosis in a fatal case of severe fever with thrombocytopenia syndrome. In: Internal Medicine. 2017 ; Vol. 56, No. 12. pp. 1597-1602.
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Nakano, A, Ogawa, H, Nakanishi, Y, Fujita, H, Mahara, F, Shiogama, K, Tsutsumi, Y & Takeichi, T 2017, 'Hemophagocytic lymphohistiocytosis in a fatal case of severe fever with thrombocytopenia syndrome', Internal Medicine, vol. 56, no. 12, pp. 1597-1602. https://doi.org/10.2169/internalmedicine.56.6904

Hemophagocytic lymphohistiocytosis in a fatal case of severe fever with thrombocytopenia syndrome. / Nakano, Ayako; Ogawa, Hirohisa; Nakanishi, Yoshinori; Fujita, Hiromi; Mahara, Fumihiko; Shiogama, Kazuya; Tsutsumi, Yutaka; Takeichi, Toshiaki.

In: Internal Medicine, Vol. 56, No. 12, 01.01.2017, p. 1597-1602.

Research output: Contribution to journalArticle

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