TY - JOUR
T1 - Hemophagocytic lymphohistiocytosis in a fatal case of severe fever with thrombocytopenia syndrome
AU - Nakano, Ayako
AU - Ogawa, Hirohisa
AU - Nakanishi, Yoshinori
AU - Fujita, Hiromi
AU - Mahara, Fumihiko
AU - Shiogama, Kazuya
AU - Tsutsumi, Yutaka
AU - Takeichi, Toshiaki
N1 - Publisher Copyright:
© 2017 The Japanese Society of Internal Medicine.
PY - 2017
Y1 - 2017
N2 - Severe fever with thrombocytopenia syndrome (SFTS) is an emerging disease caused by a novel Bunyavirus with a high mortality rate. We herein report a fatal case of an 86-year-old woman with SFTS complaining of a fever, fatigue, and bicytopenia. Her condition deteriorated with rapid progression of bleeding tendency, disturbance of consciousness, and multiple organ failure leading to death on Day 6 of her illness. The histopathological findings in the autopsy revealed marked infiltration of macrophages with hemophagocytosis in the bone marrow, liver, and spleen leading to a diagnosis of hemophagocytic lymphohistiocytosis (HLH). HLH might be a critical pathogenesis in fatal cases of SFTS.
AB - Severe fever with thrombocytopenia syndrome (SFTS) is an emerging disease caused by a novel Bunyavirus with a high mortality rate. We herein report a fatal case of an 86-year-old woman with SFTS complaining of a fever, fatigue, and bicytopenia. Her condition deteriorated with rapid progression of bleeding tendency, disturbance of consciousness, and multiple organ failure leading to death on Day 6 of her illness. The histopathological findings in the autopsy revealed marked infiltration of macrophages with hemophagocytosis in the bone marrow, liver, and spleen leading to a diagnosis of hemophagocytic lymphohistiocytosis (HLH). HLH might be a critical pathogenesis in fatal cases of SFTS.
KW - Bunyavirus
KW - Hemophagocytic lymphohistiocytosis
KW - SFTS
KW - Tick-borne infectious disease
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U2 - 10.2169/internalmedicine.56.6904
DO - 10.2169/internalmedicine.56.6904
M3 - Article
C2 - 28626191
AN - SCOPUS:85020496600
SN - 0918-2918
VL - 56
SP - 1597
EP - 1602
JO - Internal Medicine
JF - Internal Medicine
IS - 12
ER -