Hemophagocytic lymphohistiocytosis in a fatal case of severe fever with thrombocytopenia syndrome

Ayako Nakano, Hirohisa Ogawa, Yoshinori Nakanishi, Hiromi Fujita, Fumihiko Mahara, Kazuya Shiogama, Yutaka Tsutsumi, Toshiaki Takeichi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging disease caused by a novel Bunyavirus with a high mortality rate. We herein report a fatal case of an 86-year-old woman with SFTS complaining of a fever, fatigue, and bicytopenia. Her condition deteriorated with rapid progression of bleeding tendency, disturbance of consciousness, and multiple organ failure leading to death on Day 6 of her illness. The histopathological findings in the autopsy revealed marked infiltration of macrophages with hemophagocytosis in the bone marrow, liver, and spleen leading to a diagnosis of hemophagocytic lymphohistiocytosis (HLH). HLH might be a critical pathogenesis in fatal cases of SFTS.

Original languageEnglish
Pages (from-to)1597-1602
Number of pages6
JournalInternal Medicine
Volume56
Issue number12
DOIs
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Fingerprint Dive into the research topics of 'Hemophagocytic lymphohistiocytosis in a fatal case of severe fever with thrombocytopenia syndrome'. Together they form a unique fingerprint.

  • Cite this

    Nakano, A., Ogawa, H., Nakanishi, Y., Fujita, H., Mahara, F., Shiogama, K., Tsutsumi, Y., & Takeichi, T. (2017). Hemophagocytic lymphohistiocytosis in a fatal case of severe fever with thrombocytopenia syndrome. Internal Medicine, 56(12), 1597-1602. https://doi.org/10.2169/internalmedicine.56.6904