Hepatic arterial infusion chemotherapy for colorectal liver metastases

Takashi Kumada, Yasuhiro Sone, Hidenori Toyoda, Seiki Kiriyama, Makoto Tanikawa, Yasuhiro Hisanaga, Teiji Kuzuya, Kouji Nonogaki, Juniti Shimizu, Takahiro Yamauti, Noboru Kawase

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


Hepatic metastases are a frequent complication of colorectal cancer. Resection of liver metastases can result in long-term survival. However, the majority of patients have unresectable disease. Alternative methods in Japan for treating these patients are hepatic arterial infusion (HAI) chemotherapy with administration of 1,000 mg/m2 of 5-FU over 5 hours. We summarize the status of HAI chemotherapy in terms of colorectal hepatic metastases today. HAI chemotherapy produced higher response rates compared with systemic chemotherapy, but did not demonstrate elongation of survival time in many trials. Important problems remaining to be solved are the technical aspects of percutaneous implantation of intraarterial catheters connected to a subcutaneous infusion reservoir and studies of combined therapy with systemic chemotherapy. Furthermore, in order to finally determine the position of HAI for colorectal liver metastases, it is necessary to conduct a comparative study versus systemic chemotherapy, using the survival time as the primary end point.

Original languageEnglish
Pages (from-to)700-705
Number of pages6
JournalGan to kagaku ryoho. Cancer & chemotherapy
Issue number5
Publication statusPublished - 05-2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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