Hepatic CT perfusion measurements: A feasibility study for radiation dose reduction using new image reconstruction method

Noriyuki Negi, Takeshi Yoshikawa, Yoshiharu Ohno, Yuichiro Somiya, Toshinori Sekitani, Naoki Sugihara, Hisanobu Koyama, Tomonori Kanda, Naoki Kanata, Tohru Murakami, Hideaki Kawamitsu, Kazuro Sugimura

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Objectives: To assess the effects of image reconstruction method on hepatic CT perfusion (CTP) values using two CT protocols with different radiation doses. Materials and methods: Sixty patients underwent hepatic CTP and were randomly divided into two groups. Tube currents of 210 or 250 mA were used for the standard dose group and 120 or 140 mA for the low dose group. The higher currents were selected for large patients. Demographic features of the groups were compared. CT images were reconstructed by using filtered back projection (FBP), image filter (quantum de-noising, QDS), and adaptive iterative dose reduction (AIDR). Hepatic arterial and portal perfusion (HAP and HPP, ml/min/100 ml) and arterial perfusion fraction (APF, %) were calculated using the dual-input maximum slope method. ROIs were placed on each hepatic segment. Perfusion and Hounsfield unit (HU) values, and image noises (standard deviations of HU value, SD) were measured and compared between the groups and among the methods. Results: There were no significant differences in the demographic features of the groups, nor were there any significant differences in mean perfusion and HU values for either the groups or the image reconstruction methods. Mean SDs of each of the image reconstruction methods were significantly lower (p < 0.0001) for the standard dose group than the low dose group, while mean SDs for AIDR were significantly lower than those for FBP for both groups (p = 0.0006 and 0.013). Radiation dose reductions were approximately 45%. Conclusions: Image reconstruction method did not affect hepatic perfusion values calculated by dual-input maximum slope method with or without radiation dose reductions. AIDR significantly reduced images noises.

Original languageEnglish
Pages (from-to)3048-3054
Number of pages7
JournalEuropean journal of radiology
Issue number11
Publication statusPublished - 11-2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging


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