Hepatic sarcoidosis mimicking hilar cholangiocarcinoma: Case report and review of the literature

Keiichi Suzuki, Zenichi Morise, Shimpei Furuta, Yoshinao Tanahashi, Chinatsu Takeura, Tadashi Kagawa, Masahiro Ikeda, Atsushi Sugioka

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Sarcoidosis is a multisystemic granulomatous disease of unknown etiology. Hepatic involvement was reported in about 11% of patients with sarcoidosis. However, cases of sarcoidosis in which the granuloma is solitary and limited in the liver are very rare. A 51-year-old woman with tumors in the liver underwent extended left lobectomy with caudate lobectomy and bile duct resection. The tumor was located between segment 4 and the hilar region. Some daughter nodules were found in the left lobe, which were regarded as intrahepatic metastasis. Our case displayed clinical and radiologically distinct findings, which are very similar to those of hilar cholangiocarcinoma restricted to the liver. This report demonstrates that sarcoidosis can show solitary hepatic involvement in the absence of thoracic lymphadenopathy. In such a case, it is difficult to distinguish the diagnosis from other malignant neoplasms. In conclusion, the diagnosis of hepatic sarcoidosis has to be made through prudent and comprehensive investigations that include a full clinical history of sarcoidosis in other organs. Despite utilizing several detailed diagnostic modalities, the definitive diagnosis of cases of solitary sarcoidosis may remain difficult. In these cases, surgical treatment including liver resection should be considered in order to avoid missing a suitable opportunity for treatment.

Original languageEnglish
Pages (from-to)152-158
Number of pages7
JournalCase Reports in Gastroenterology
Issue number1
Publication statusPublished - 01-2011

All Science Journal Classification (ASJC) codes

  • Gastroenterology


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