Hepatitis B e antigen and hepatitis B surface antigen seroclearance with the emergence of lamivudine-associated and core mutations following CD4 elevation in a patient with hepatitis B and HIV

Takashi Honda; Masatoshi Ishigami; Fangqiong Luo; Yoji Ishizu; Teiji Kuzuya; Kazuhiko Hayashi; Akihiro Itoh; Yoshiki Hirooka; Tetsuya Ishikawa; Isao Nakano; Yoshiaki Katano; Hidemi Goto

doi:10.2169/internalmedicine.54.2038

Hepatitis B e antigen and hepatitis B surface antigen seroclearance with the emergence of lamivudine-associated and core mutations following CD4 elevation in a patient with hepatitis B and HIV

Takashi Honda, Masatoshi Ishigami, Fangqiong Luo, Yoji Ishizu, Teiji Kuzuya, Kazuhiko Hayashi, Akihiro Itoh, Yoshiki Hirooka, Tetsuya Ishikawa, Isao Nakano, Yoshiaki Katano, Hidemi Goto

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Obtaining a better understanding of the mechanisms associated with hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) loss in patients with hepatitis B virus (HBV) is important for treating pa-tients with chronic hepatitis B. We herein describe the case of a patient with HBV and human immunodefi-ciency virus whose chronic hepatitis was stabilized due to HBe and HBs seroconversion with the emergence of lamivudine-associated and core mutations after CD4 elevation. A full-length HBV DNA analysis indicated that HBsAg had been lost after the development of the rtS143T mutation, which corresponded to the emer-gence of the sF134L and core mutations. The details of this case shed some light on the mechanisms associ-ated with HBsAg and HBeAg clearance.

Original language	English
Pages (from-to)	585-590
Number of pages	6
Journal	Internal Medicine
Volume	54
Issue number	6
DOIs	https://doi.org/10.2169/internalmedicine.54.2038
Publication status	Published - 2015
Externally published	Yes

All Science Journal Classification (ASJC) codes

Internal Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2169/internalmedicine.54.2038

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Honda, T., Ishigami, M., Luo, F., Ishizu, Y., Kuzuya, T., Hayashi, K., Itoh, A., Hirooka, Y., Ishikawa, T., Nakano, I., Katano, Y., & Goto, H. (2015). Hepatitis B e antigen and hepatitis B surface antigen seroclearance with the emergence of lamivudine-associated and core mutations following CD4 elevation in a patient with hepatitis B and HIV. Internal Medicine, 54(6), 585-590. https://doi.org/10.2169/internalmedicine.54.2038

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title = "Hepatitis B e antigen and hepatitis B surface antigen seroclearance with the emergence of lamivudine-associated and core mutations following CD4 elevation in a patient with hepatitis B and HIV",

abstract = "Obtaining a better understanding of the mechanisms associated with hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) loss in patients with hepatitis B virus (HBV) is important for treating pa-tients with chronic hepatitis B. We herein describe the case of a patient with HBV and human immunodefi-ciency virus whose chronic hepatitis was stabilized due to HBe and HBs seroconversion with the emergence of lamivudine-associated and core mutations after CD4 elevation. A full-length HBV DNA analysis indicated that HBsAg had been lost after the development of the rtS143T mutation, which corresponded to the emer-gence of the sF134L and core mutations. The details of this case shed some light on the mechanisms associ-ated with HBsAg and HBeAg clearance.",

author = "Takashi Honda and Masatoshi Ishigami and Fangqiong Luo and Yoji Ishizu and Teiji Kuzuya and Kazuhiko Hayashi and Akihiro Itoh and Yoshiki Hirooka and Tetsuya Ishikawa and Isao Nakano and Yoshiaki Katano and Hidemi Goto",

note = "Publisher Copyright: {\textcopyright} 2015 The Japanese Society of Internal Medicine.",

year = "2015",

doi = "10.2169/internalmedicine.54.2038",

language = "English",

volume = "54",

pages = "585--590",

journal = "Internal Medicine",

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Honda, T, Ishigami, M, Luo, F, Ishizu, Y, Kuzuya, T, Hayashi, K, Itoh, A, Hirooka, Y, Ishikawa, T, Nakano, I, Katano, Y & Goto, H 2015, 'Hepatitis B e antigen and hepatitis B surface antigen seroclearance with the emergence of lamivudine-associated and core mutations following CD4 elevation in a patient with hepatitis B and HIV', Internal Medicine, vol. 54, no. 6, pp. 585-590. https://doi.org/10.2169/internalmedicine.54.2038

Hepatitis B e antigen and hepatitis B surface antigen seroclearance with the emergence of lamivudine-associated and core mutations following CD4 elevation in a patient with hepatitis B and HIV. / Honda, Takashi; Ishigami, Masatoshi; Luo, Fangqiong et al.
In: Internal Medicine, Vol. 54, No. 6, 2015, p. 585-590.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Hepatitis B e antigen and hepatitis B surface antigen seroclearance with the emergence of lamivudine-associated and core mutations following CD4 elevation in a patient with hepatitis B and HIV

AU - Honda, Takashi

AU - Ishigami, Masatoshi

AU - Luo, Fangqiong

AU - Ishizu, Yoji

AU - Kuzuya, Teiji

AU - Hayashi, Kazuhiko

AU - Itoh, Akihiro

AU - Hirooka, Yoshiki

AU - Ishikawa, Tetsuya

AU - Nakano, Isao

AU - Katano, Yoshiaki

AU - Goto, Hidemi

PY - 2015

Y1 - 2015

N2 - Obtaining a better understanding of the mechanisms associated with hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) loss in patients with hepatitis B virus (HBV) is important for treating pa-tients with chronic hepatitis B. We herein describe the case of a patient with HBV and human immunodefi-ciency virus whose chronic hepatitis was stabilized due to HBe and HBs seroconversion with the emergence of lamivudine-associated and core mutations after CD4 elevation. A full-length HBV DNA analysis indicated that HBsAg had been lost after the development of the rtS143T mutation, which corresponded to the emer-gence of the sF134L and core mutations. The details of this case shed some light on the mechanisms associ-ated with HBsAg and HBeAg clearance.

AB - Obtaining a better understanding of the mechanisms associated with hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) loss in patients with hepatitis B virus (HBV) is important for treating pa-tients with chronic hepatitis B. We herein describe the case of a patient with HBV and human immunodefi-ciency virus whose chronic hepatitis was stabilized due to HBe and HBs seroconversion with the emergence of lamivudine-associated and core mutations after CD4 elevation. A full-length HBV DNA analysis indicated that HBsAg had been lost after the development of the rtS143T mutation, which corresponded to the emer-gence of the sF134L and core mutations. The details of this case shed some light on the mechanisms associ-ated with HBsAg and HBeAg clearance.

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SN - 0918-2918

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SP - 585

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JO - Internal Medicine

JF - Internal Medicine

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Hepatitis B e antigen and hepatitis B surface antigen seroclearance with the emergence of lamivudine-associated and core mutations following CD4 elevation in a patient with hepatitis B and HIV

Abstract

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