TY - JOUR
T1 - Hepatitis E virus subtype 3f infections
T2 - rare but increasingly identified in Japan
AU - Nakano, Tatsunori
AU - Okano, Hiroshi
AU - Uraki, Satoko
AU - Ono, Takahiro
AU - Shimizu, Atsuya
AU - Takahashi, Masaharu
AU - Nagashima, Shigeo
AU - Murata, Kazumoto
AU - Okamoto, Hiroaki
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2025.
PY - 2025/12
Y1 - 2025/12
N2 - Forty-two human-derived hepatitis E virus subtype 3f (HEV-3f) strains, identified in Japan between 1998 and 2024, were analyzed based on their genome sequences. Fourteen strains in the Kanto region and two in Mie Prefecture exhibited close genetic relatedness to each other but were distinct from European HEV-3f strains, suggesting possible endemic circulation in Japan. Conversely, seven strains from individuals without a history of travel shared identical nucleotide sequences with European HEV-3f, suggesting that these infections were potentially linked to imported pork. Comprehensive molecular and epidemiological studies are needed to clarify the relative contributions of local zoonotic transmission from domestic or wild animals versus foodborne introduction via imported pork products.
AB - Forty-two human-derived hepatitis E virus subtype 3f (HEV-3f) strains, identified in Japan between 1998 and 2024, were analyzed based on their genome sequences. Fourteen strains in the Kanto region and two in Mie Prefecture exhibited close genetic relatedness to each other but were distinct from European HEV-3f strains, suggesting possible endemic circulation in Japan. Conversely, seven strains from individuals without a history of travel shared identical nucleotide sequences with European HEV-3f, suggesting that these infections were potentially linked to imported pork. Comprehensive molecular and epidemiological studies are needed to clarify the relative contributions of local zoonotic transmission from domestic or wild animals versus foodborne introduction via imported pork products.
UR - https://www.scopus.com/pages/publications/105021958360
UR - https://www.scopus.com/pages/publications/105021958360#tab=citedBy
U2 - 10.1007/s00705-025-06467-3
DO - 10.1007/s00705-025-06467-3
M3 - Article
C2 - 41240122
AN - SCOPUS:105021958360
SN - 0304-8608
VL - 170
JO - Archives of Virology
JF - Archives of Virology
IS - 12
M1 - 252
ER -
