Hepatitis E virus subtype 3f strains isolated from Japanese hepatitis patients with no history of travel to endemic areas – The origin analyzed by molecular evolution

Tatsunori Nakano; Masaharu Takahashi; Kazuaki Takahashi; Shigeo Nagashima; Yusuke Suzuki; Yoichi Nishigaki; Eiichi Tomita; Hiroshi Okano; Yumi Oya; Katsuya Shiraki; Kojiro Takase; Kazushi Sugimoto; Junichi Koyama; Hitoshi Mizuo; Kazuto Ikezawa; Tatsuya Aikawa; Masahiro Arai; Hiroaki Okamoto

doi:10.1016/j.virol.2017.08.008

Hepatitis E virus subtype 3f strains isolated from Japanese hepatitis patients with no history of travel to endemic areas – The origin analyzed by molecular evolution

Tatsunori Nakano, Masaharu Takahashi, Kazuaki Takahashi, Shigeo Nagashima, Yusuke Suzuki, Yoichi Nishigaki, Eiichi Tomita, Hiroshi Okano, Yumi Oya, Katsuya Shiraki, Kojiro Takase, Kazushi Sugimoto, Junichi Koyama, Hitoshi Mizuo, Kazuto Ikezawa, Tatsuya Aikawa, Masahiro Arai, Hiroaki Okamoto

Internal Medicine

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Abstract

Hepatitis E virus subtype 3f (HEV-3f) strains are usually isolated in Europe and Thailand. Recently, HEV-3f strains were detected from six acute hepatitis E patients in Japan, none of whom had a history of travel to endemic areas. We inferred the origin and transmission route of the six HEV-3f strains. A time-scaled phylogenetic tree of the six strains with reference strains was constructed using a Bayesian statistical inference framework. The time-scaled tree indicated that the six strains independently derived from similar European strains between 2008 and 2014. The pattern suggested recent inflow of multiple HEV-3f strains from Europe to Japan. Japan imports a substantial amount of pork from European countries every year. The emergence of acute hepatitis cases caused by HEV-3f strains in Japan, in patients with no history of travel abroad, might be influenced by the increased opportunities to consume pork products imported from European countries.

Original language	English
Pages (from-to)	146-152
Number of pages	7
Journal	Virology
Volume	513
DOIs	https://doi.org/10.1016/j.virol.2017.08.008
Publication status	Published - 01-01-2018

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Virology

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10.1016/j.virol.2017.08.008

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Nakano, T., Takahashi, M., Takahashi, K., Nagashima, S., Suzuki, Y., Nishigaki, Y., Tomita, E., Okano, H., Oya, Y., Shiraki, K., Takase, K., Sugimoto, K., Koyama, J., Mizuo, H., Ikezawa, K., Aikawa, T., Arai, M., & Okamoto, H. (2018). Hepatitis E virus subtype 3f strains isolated from Japanese hepatitis patients with no history of travel to endemic areas – The origin analyzed by molecular evolution. Virology, 513, 146-152. https://doi.org/10.1016/j.virol.2017.08.008

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title = "Hepatitis E virus subtype 3f strains isolated from Japanese hepatitis patients with no history of travel to endemic areas – The origin analyzed by molecular evolution",

abstract = "Hepatitis E virus subtype 3f (HEV-3f) strains are usually isolated in Europe and Thailand. Recently, HEV-3f strains were detected from six acute hepatitis E patients in Japan, none of whom had a history of travel to endemic areas. We inferred the origin and transmission route of the six HEV-3f strains. A time-scaled phylogenetic tree of the six strains with reference strains was constructed using a Bayesian statistical inference framework. The time-scaled tree indicated that the six strains independently derived from similar European strains between 2008 and 2014. The pattern suggested recent inflow of multiple HEV-3f strains from Europe to Japan. Japan imports a substantial amount of pork from European countries every year. The emergence of acute hepatitis cases caused by HEV-3f strains in Japan, in patients with no history of travel abroad, might be influenced by the increased opportunities to consume pork products imported from European countries.",

author = "Tatsunori Nakano and Masaharu Takahashi and Kazuaki Takahashi and Shigeo Nagashima and Yusuke Suzuki and Yoichi Nishigaki and Eiichi Tomita and Hiroshi Okano and Yumi Oya and Katsuya Shiraki and Kojiro Takase and Kazushi Sugimoto and Junichi Koyama and Hitoshi Mizuo and Kazuto Ikezawa and Tatsuya Aikawa and Masahiro Arai and Hiroaki Okamoto",

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doi = "10.1016/j.virol.2017.08.008",

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Nakano, T, Takahashi, M, Takahashi, K, Nagashima, S, Suzuki, Y, Nishigaki, Y, Tomita, E, Okano, H, Oya, Y, Shiraki, K, Takase, K, Sugimoto, K, Koyama, J, Mizuo, H, Ikezawa, K, Aikawa, T, Arai, M & Okamoto, H 2018, 'Hepatitis E virus subtype 3f strains isolated from Japanese hepatitis patients with no history of travel to endemic areas – The origin analyzed by molecular evolution', Virology, vol. 513, pp. 146-152. https://doi.org/10.1016/j.virol.2017.08.008

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T1 - Hepatitis E virus subtype 3f strains isolated from Japanese hepatitis patients with no history of travel to endemic areas – The origin analyzed by molecular evolution

AU - Nakano, Tatsunori

AU - Takahashi, Masaharu

AU - Takahashi, Kazuaki

AU - Nagashima, Shigeo

AU - Suzuki, Yusuke

AU - Nishigaki, Yoichi

AU - Tomita, Eiichi

AU - Okano, Hiroshi

AU - Oya, Yumi

AU - Shiraki, Katsuya

AU - Takase, Kojiro

AU - Sugimoto, Kazushi

AU - Koyama, Junichi

AU - Mizuo, Hitoshi

AU - Ikezawa, Kazuto

AU - Aikawa, Tatsuya

AU - Arai, Masahiro

AU - Okamoto, Hiroaki

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Hepatitis E virus subtype 3f (HEV-3f) strains are usually isolated in Europe and Thailand. Recently, HEV-3f strains were detected from six acute hepatitis E patients in Japan, none of whom had a history of travel to endemic areas. We inferred the origin and transmission route of the six HEV-3f strains. A time-scaled phylogenetic tree of the six strains with reference strains was constructed using a Bayesian statistical inference framework. The time-scaled tree indicated that the six strains independently derived from similar European strains between 2008 and 2014. The pattern suggested recent inflow of multiple HEV-3f strains from Europe to Japan. Japan imports a substantial amount of pork from European countries every year. The emergence of acute hepatitis cases caused by HEV-3f strains in Japan, in patients with no history of travel abroad, might be influenced by the increased opportunities to consume pork products imported from European countries.

AB - Hepatitis E virus subtype 3f (HEV-3f) strains are usually isolated in Europe and Thailand. Recently, HEV-3f strains were detected from six acute hepatitis E patients in Japan, none of whom had a history of travel to endemic areas. We inferred the origin and transmission route of the six HEV-3f strains. A time-scaled phylogenetic tree of the six strains with reference strains was constructed using a Bayesian statistical inference framework. The time-scaled tree indicated that the six strains independently derived from similar European strains between 2008 and 2014. The pattern suggested recent inflow of multiple HEV-3f strains from Europe to Japan. Japan imports a substantial amount of pork from European countries every year. The emergence of acute hepatitis cases caused by HEV-3f strains in Japan, in patients with no history of travel abroad, might be influenced by the increased opportunities to consume pork products imported from European countries.

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Hepatitis E virus subtype 3f strains isolated from Japanese hepatitis patients with no history of travel to endemic areas – The origin analyzed by molecular evolution

Abstract

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